DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Npr1 and ACXD

DIOPT Version :9

Sequence 1:	NP_036745.1	Gene:	Npr1 / 24603	RGDID:	3195	Length:	1057	Species:	Rattus norvegicus
Sequence 2:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster

Alignment Length:	414	Identity:	104/414 - (25%)
Similarity:	187/414 - (45%)	Gaps:	87/414 - (21%)

- Green bases have known domain annotations that are detailed below.

  Rat   669 VLKITDYGLESFRDPEPE-------QGHTLFAKKLW-TAPELLRMASPPARGSQAGDV----YSF 721
            |:.:.|.||..:......       ..:||:|..:: ..|.||:   |...||.....    |||
  Fly   136 VMVLMDIGLNVYHATSHNDILNPIYDAYTLYAIYMFMPVPYLLQ---PFVLGSAVTFCYIINYSF 197

  Rat   722 GI----------ILQEIALRS-----GVFYVEGLDLSPKEIIERVTRGEQPPFRPSMDLQSHLEE 771
            .|          ||.|....|     |:|:     ...::|..|.|         .:|.:.::||
  Fly   198 VITAKDDNQMHSILNEAIYLSCVNLLGIFF-----RLMRDIALRTT---------FLDRRQYVEE 248

  Rat   772 LGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQYANNLEELVEE-RTQAYL 835
              .|:.| :|.| |||.....|..|          .|.|.|   .|...|.:|...:: :.|:.:
  Fly   249 --NLLLR-YARD-QERSLLLSILPA----------QIADRL---QEDVKNRIERSKQQHQQQSQV 296

  Rat   836 EEKRKAEALLYQILPHSVAEQLKRGE-----TVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVT 895
            :.:|.|:           ::.|||..     |:..|..:.||:.::|:|.:|.|:......::|.
  Fly   297 DLRRSAD-----------SQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVE 350

  Rat   896 LLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHR 960
            .|:||:..||...:.::|.:::.:||.|..|:||...|.. ||:....:.|.::..:|.  :|.:
  Fly   351 ALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNAD-HAKCCVDLGLRMIKDIRD--VREK 412

  Rat   961 PQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLE-EF- 1023
            ....:.:|||:|:|.|.:||:|....::.::...|:.|:|:|:.|...::|:|.:|.::|: |:
  Fly   413 RHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYF 477

  Rat  1024 --DGFELELRGDVEMKGKGKVRTY 1045
              ||.| :.|.|..::..| :||:
  Fly   478 FEDGTE-KAREDPVLQKHG-IRTF 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Npr1	NP_036745.1	PBP1_NPR_A	32..439	CDD:107380
		ANF_receptor	50..410	CDD:279440
		PK_GC-A_B	530..803	CDD:270944	38/160 (24%)
		TyrKc	543..797	CDD:197581	37/154 (24%)
		HNOBA	<812..857	CDD:285003	7/45 (16%)
		CYCc	836..1025	CDD:214485	51/197 (26%)
		Guanylate_cyc	863..1049	CDD:278633	53/187 (28%)
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	43/181 (24%)
		CYCc	254..476	CDD:214485	64/249 (26%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	53/184 (29%)
		CYCc	856..1117	CDD:214485
		Nucleotidyl_cyc_III	878..1142	CDD:299850
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900