DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Npr1 and ACXC

DIOPT Version :9

Sequence 1:	NP_036745.1	Gene:	Npr1 / 24603	RGDID:	3195	Length:	1057	Species:	Rattus norvegicus
Sequence 2:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster

Alignment Length:	329	Identity:	90/329 - (27%)
Similarity:	134/329 - (40%)	Gaps:	95/329 - (28%)

- Green bases have known domain annotations that are detailed below.

  Rat   789 PFQQIRLA---------LRKFNKENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAE-- 842
            ||.:..||         |..:.||..|.....:     .|..|::          |:.|:||.
  Fly   782 PFMKAELAHCLRVCMMLLTMYAKERQSEFNTKM-----NYKLNVD----------LQNKQKAADL 831

  Rat   843 ------ALLYQILPHSVAE----QLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTL- 896
                  .||..|||..|.:    .|.:.| :..|.:..|::.|:.::.|        ||.:.:|
  Fly   832 TNQSIIILLNNILPSHVVDLYLNSLAKHE-LYYENYRMVSVMFAMLINF--------PMNLPSLR 887

  Rat   897 -LNDLYTCFDAVIDNFDVY----KVETIGDAYMVVSGLP------------VRNGQLHAR-EVAR 943
             |||:.|.||.::..:..|    |::.:|..||...||.            .||..||.. |.||
  Fly   888 VLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHAR 952

  Rat   944 ---------------------MALALLDAVR---------SFRIRHRPQEQLRLRIGIHTGPVCA 978
                                 |....||.:|         |.....|...|.::.|||.:|.:.|
  Fly   953 NHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMA 1017

  Rat   979 GVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVR 1043
            ||||...|.|.::|:.||.||||||.|....|.::.|:..:|:||| .:...||...:||:|.:.
  Fly  1018 GVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKILQEFD-IKCIYRGMTFVKGRGDIP 1081

  Rat  1044 TYWL 1047
            ||::
  Fly  1082 TYFV 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Npr1	NP_036745.1	PBP1_NPR_A	32..439	CDD:107380
		ANF_receptor	50..410	CDD:279440
		PK_GC-A_B	530..803	CDD:270944	5/22 (23%)
		TyrKc	543..797	CDD:197581	4/16 (25%)
		HNOBA	<812..857	CDD:285003	12/56 (21%)
		CYCc	836..1025	CDD:214485	71/249 (29%)
		Guanylate_cyc	863..1049	CDD:278633	68/234 (29%)
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831
		CYCc	293..468	CDD:214485
		Nucleotidyl_cyc_III	307..466	CDD:299850
		CYCc	833..1060	CDD:214485	65/235 (28%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	68/232 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900