DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Npr1 and Gyc32E

DIOPT Version :9

Sequence 1:	NP_036745.1	Gene:	Npr1 / 24603	RGDID:	3195	Length:	1057	Species:	Rattus norvegicus
Sequence 2:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster

Alignment Length:	1132	Identity:	394/1132 - (34%)
Similarity:	587/1132 - (51%)	Gaps:	141/1132 - (12%)

- Green bases have known domain annotations that are detailed below.

  Rat     1 MPGSRRVRPRLRALLLLPPLLLLRGGH-----ASDLTVAVVLPLTNT-------SYPWSWARVGP 53
            |||..........:|    :|||.|..     |:..||:.:..||:|       .|......:|
  Fly     1 MPGPCASAAAFSCIL----VLLLLGCQRSNPLAAGATVSSMRRLTDTINIGFLAEYSQMRVTLG- 60

  Rat    54 AVELALARVKARPDLLPGWTVR---MVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGP--G 113
            .:.||:..|...|:||||..:.   :.:|...:|..|     .||.|:....|.....|:||  .
  Fly    61 GLPLAIEDVNKNPNLLPGKKLAFKPVDIGHKMSAYRV-----KPLRAMTQMREAGVTAFIGPDES 120

  Rat   114 CVYSAAPVGRFTAHWRVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQA 178
            |...|.    ..:.|..|:|:.......:..|..:....||.....|:...|.:|.....|...:
  Fly   121 CTTEAL----LASAWNTPMLSFKCSDPIVSNKSTFHTFARTLAPASKVSKSVISLLNAFHWNKFS 181

  Rat   179 LVLYADRL-GDDRPCFFIVEGLYMRVRERLNITVNHQEFVEGDPDHYP---------KLLRAVRR 233
            :|:.:..: |.|      |......:.|..|.|::|.:::.   |:.|         |::.....
  Fly   182 IVVSSKPIWGSD------VARAIQELAEARNFTISHFKYIS---DYIPTTKTLSQIDKIIEETYA 237

  Rat   234 KGRV-IYI---CSSPDAFRNLMLLALNAGLTGEDYVFFHLD--VFGQ----SLKSAQGLVPQKPW 288
            ..|: ::|   .:..|..|.|....|   |...||:...:|  ::..    ::.....|.|....
  Fly   238 TTRIYVFIGEHIAMVDFVRGLQNRRL---LESGDYIVVSVDDEIYDSNRRVNIMERNYLDPYIRK 299

  Rat   289 ERGDGQDRSARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADK-----KFNFTVEDGLK-NIIPA 347
            |:....|:.   :|::...|:...|.||...:...::|..|.|     .::..|.|.:. .|...
  Fly   300 EKSKSLDKI---SFRSVIKISMTYPQNPHIRDICSKIKDYARKTPFLVPYHQRVFDNISVPIYGL 361

  Rat   348 SFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGY-LKIDRNGDRDTDFSLWDMDP 411
            ..:|.:::||:|:||.|..||.:.||..:...::|||:..:.|: :.||.|||.:.::::..:..
  Fly   362 HLYDSVMIYVRAITEVLRLGGDIYDGNLVMSHIFNRSYHSIQGFDVYIDSNGDAEGNYTVITLQN 426

  Rat   412 ETGA----------------------------FRVVLNYNGTSQELMAVSEHKLYWPLGYPPPDV 448
            :.|:                            ||.:.|            :..:.|..|.||...
  Fly   427 DVGSGASIGSLAKMSMQPVGFFAYDKNSVIPEFRYIKN------------DRPIQWLNGRPPLAE 479

  Rat   449 PKCGFDNEDPACNQDHFSTLEVLALV-GSLSLISFLIVSFFIYRKMQLEKELVSELWRVRWEDLQ 512
            |.|||..|  .|.:   ..|:...|| |.|..:..::....:.:..:.|:.|...||:|..:|:.
  Fly   480 PLCGFHGE--LCPR---KKLDWRYLVSGPLCALVVVVAIALLIKHYRYEQTLAGLLWKVDMKDVT 539

  Rat   513 PSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVL 577
            ..:|..:.......:....|.|   .|:..|...:.|...|.::||:||:|::::|.:::||.:.
  Fly   540 VINLGEYNNPTNKNIFQICRQS---ILVVGEPNKRSFTNIALFRGNIVAMKKIHKKSVDITRSIR 601

  Rat   578 FELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKG 642
            .|||.||:|::|::..|:||.||..::.|.|.||.||||:|:|.||.:.||.||..||.:||:||
  Fly   602 KELKLMREVRHENIINFIGASTDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKG 666

  Rat   643 MLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFR--DPEPEQGHTLFAKKLWTAPELLRM 705
            |::||:..|.|||||:||||::|.|:|.:|:|:||...:  ..||.:......:.|..||||||.
  Fly   667 MIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQEEPNKSELELKRALCMAPELLRD 731

  Rat   706 ASPPARGSQAGDVYSFGIILQEIALRSGVF----YVEGLDLSPKEIIERVTRGE---QPPFRPSM 763
            |..|.||||.||||||||:|.|:..|.|.:    |      |.:|||:.|...|   ...|||::
  Fly   732 AYRPGRGSQKGDVYSFGILLYEMIGRKGPWGDTAY------SKEEIIQFVKCPEMLQHGVFRPAL 790

  Rat   764 DLQSHL---EELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQYANNLEE 825
             ..:||   :.:.:.:.:||.|||:.||..:.:|:.|::.......||.||:||.||:||.|||.
  Fly   791 -THTHLDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEG 854

  Rat   826 LVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTP 890
            ||:|||....|||:|.:.||||:||..|||.||||:.|:||.||.|||.||||||||.|...|||
  Fly   855 LVQERTNLLYEEKKKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTP 919

  Rat   891 MQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSF 955
            .:||.:|||.|||.|::|.|:|||||||||||||||||||::||..||.|:|.:||.||:.|.:.
  Fly   920 FEVVEMLNDWYTCCDSIISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNL 984

  Rat   956 RIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVL 1020
            :|||:|.|.::||||:|:||..|||||.||||||||||||||||||||.|::::||:|..|..:|
  Fly   985 KIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLL 1049

  Rat  1021 EEFDGFELELRGDVEMKGKGKVRTYWL 1047
            :....:....||...:||||.:|||||
  Fly  1050 QVIGSYVCIERGLTSIKGKGDMRTYWL 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Npr1	NP_036745.1	PBP1_NPR_A	32..439	CDD:107380	97/473 (21%)
		ANF_receptor	50..410	CDD:279440	87/391 (22%)
		PK_GC-A_B	530..803	CDD:270944	116/284 (41%)
		TyrKc	543..797	CDD:197581	112/265 (42%)
		HNOBA	<812..857	CDD:285003	27/44 (61%)
		CYCc	836..1025	CDD:214485	121/188 (64%)
		Guanylate_cyc	863..1049	CDD:278633	115/185 (62%)
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	89/428 (21%)
		ANF_receptor	59..427	CDD:279440	87/392 (22%)
		PHA02988	534..826	CDD:165291	117/301 (39%)
		PK_GC-A_B	550..832	CDD:270944	116/291 (40%)
		HNOBA	<847..886	CDD:285003	23/38 (61%)
		CYCc	865..1057	CDD:214485	121/191 (63%)
		Guanylate_cyc	892..1076	CDD:278633	113/183 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720