Protein Alignment ATP6V1C2 and VMA5

DIOPT Version :9

• Sequence 1: XP_011508641.1
• Gene: ATP6V1C2 / 245973
• HGNCID: 18264
• Length: 437
• Species: Homo sapiens
• Sequence 2: NP_012843.1
• Gene: VMA5 / 853782
• SGDID: S000001563
• Length: 392
• Species: Saccharomyces cerevisiae
• Alignment Length: 452
• Identity: 137/452 - (30%)
• Similarity: 225/452 - (49%)
• Gaps: 88/452 - (19%)

Human     2 SEFWLISAPGDKENLQALERMNTVTSK-------SNLSYNTKFAIPDFKVGTLDSLVGLSDELGK 59
            ::|.|||.|   :|.|.:....:.|..       ...::.:.|.||:||:|:||:|:..|:||.|
Yeast     9 NDFILISLP---QNAQPVTAPGSKTDSWFNETLIGGRAFVSDFKIPEFKIGSLDTLIVESEELSK 70

Human    60 LDTFAESLIRRMAQSVVEVMEDSKGKVQEHLLANGGLKGKMKCLKID---LTSFVTHFEWDMAKY 121
            :|       .::..|:.:::|..:|       .|.......:.|.|:   :..::.:|:|...|:
Yeast    71 VD-------NQIGASIGKIIEILQG-------LNETSTNAYRTLPINNMPVPEYLENFQWQTRKF 121

Human   122 PVKQPLVSVVDTIAKQLAQIEMDLKSRTAAYNTLKTNLENLEKKSMGNLFTRTLSDIVSKEDFVL 186
            .:.:.:..::..|:.:.:|::.|:::..|.||:.||||...|:|..|:|..|:|.|||..|||||
Yeast   122 KLDKSIKDLITLISNESSQLDADVRATYANYNSAKTNLAAAERKKTGDLSVRSLHDIVKPEDFVL 186

Human   187 DSEYLVTLLVIVPKPNYSQWQKTYESLSDMVVPRSTKLITEDKEGGLFTVTLFRKVIEDFKTKAK 251
            :||:|.|:||.|||...|.::|:||:||..|||.|..:|.||.|..||.|.||:|.:::|.|.|:
Yeast   187 NSEHLTTVLVAVPKSLKSDFEKSYETLSKNVVPASASVIAEDAEYVLFNVHLFKKNVQEFTTAAR 251

Human   252 ENKFTVREFYYDEK---EIEREREEMARLLSDKKQQYQTSCVALKKGSSTFPDHKVKVTPLGNPD 313
            |.||..|||.|.|:   ::::|.:..|.|....:.|
Yeast   252 EKKFIPREFNYSEELIDQLKKEHDSAASLEQSLRVQ----------------------------- 287

Human   314 RPAAGQTDRERESEGEGEGPLLRWLKVNFSEAFIAWIHIKALRVFVESVLRYGLPVNFQAVLLQP 378
                                |:|..|..:.:.||.|.|||||||:||||||||||.:|...::..
Yeast   288 --------------------LVRLAKTAYVDVFINWFHIKALRVYVESVLRYGLPPHFNIKIIAV 332

Human   379 HKKSSTKRLREVLNSVFRHL-------DEVAATSILDASVEIPGLQLNNQDYFPYVYFHIDL 433
            ..|:.:|...|:::: |..|       |:....:..|.|:. ....|.:.:|.|:|.:.|:|
Yeast   333 PPKNLSKCKSELIDA-FGFLGGNAFMKDKKGKINKQDTSLH-QYASLVDTEYEPFVMYIINL 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP6V1C2	XP_011508641.1	V-ATPase_C	5..427	CDD:397366	133/441 (30%)
		3-helical coiled coil	55..75	CDD:270211	4/19 (21%)
		3-helical coiled coil	130..156	CDD:270211	6/25 (24%)
		3-helical coiled coil	284..361	CDD:270211	15/76 (20%)
VMA5	NP_012843.1	COG5127	6..392	CDD:227456	136/450 (30%)
		3-helical coiled coil	66..86	CDD:270211	6/26 (23%)
		3-helical coiled coil	130..156	CDD:270211	6/25 (24%)
		3-helical coiled coil	284..315	CDD:270211	15/79 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C159051674
Domainoid	1	1.000	228	1.000	Domainoid score	I478
eggNOG	1	0.900	-	-		E1_COG5127
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I836
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54067
OrthoFinder	1	1.000	-	-		FOG0001981
OrthoInspector	1	1.000	-	-		otm53216
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10137
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1630
SonicParanoid	1	1.000	-	-		X1294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.890