Protein Alignment ATP6V1C2 and Vha44

DIOPT Version :9

• Sequence 1: XP_011508641.1
• Gene: ATP6V1C2 / 245973
• HGNCID: 18264
• Length: 437
• Species: Homo sapiens
• Sequence 2: NP_001137679.1
• Gene: Vha44 / 36826
• FlyBaseID: FBgn0262511
• Length: 836
• Species: Drosophila melanogaster
• Alignment Length: 878
• Identity: 225/878 - (25%)
• Similarity: 302/878 - (34%)
• Gaps: 488/878 - (55%)

Human     1 MSEFWLISAPGDKENLQALERMNTVTSKS-NLSYNTKFAIPDFKVGTLDSLVGLSDELGKLDTFA 64
            |||:|:|||||||...|..:.||.:|||. ||..|.||.|||.||||||.||||||:||||||:.
  Fly     2 MSEYWIISAPGDKTCQQTYDTMNNLTSKQHNLCNNYKFHIPDLKVGTLDQLVGLSDDLGKLDTYV 66

Human    65 ESLIRRMAQSVVEVMEDSKGKVQEHLLANGG---------------------------------- 95
            |.:.|::|..:.||:||.:.|:.|:|:||..
  Fly    67 EQITRKVANYLGEVLEDQRDKLHENLMANNSPGPPDDSMPCRHHQRIKHLSLRHQRKHQHTHHQN 131

Human    96 -----------------LKGK-------------------------------------------- 99
                             ||||
  Fly   132 KPQHYHHHHHHHQLPQDLKGKSAATCSPATPPAPASAPPHLPPACACDVLAPGSLTGGSLTNLST 196

Human   100 -----------------------------------------------MKC--------------- 102
                                                           .:|
  Fly   197 SHEPEPEFDVCPCDECFACAPPSTSATASTLLADECYSQTASSMLSATRCALSTVAAIATGSGLG 261

Human   103 ----------------------------------------------------------------- 102
                                                                             
  Fly   262 NGPSTSAAAAAAASNSSGGGGGGGPASCSTLCSSAYFSTSAPTTSSSVHSSMSRSNSKRLNNNTC 326

Human   103 ----------------------------------------------------------------- 102
                                                                             
  Fly   327 SINNNKLSFRSGSHVSQLHLATQQPQHHHSHPHQQPHTNPLQSPVQKSMSEDEGDASNAHEDGET 391

Human   103 ----------------------------------------------------------------- 102
                                                                             
  Fly   392 DEDPKSPHSVQSDLSDAFDWWFNKPKRNSKKSSAQQQHETAQLQHQQTTQQHATPLTPQNHNQYQ 456

Human   103 ------------------------------------------LKI-------------------- 105
                                                      |.|
  Fly   457 NQHLSKAMTFWHQASTTPRSSYRSFFNSLADQIYSKRSTPSQLNINNGFNLTPTHRSSPVSSCCG 521

Human   106 ------------------------DLTSFVTHFEWDMAKYPVKQPLVSVVDTIAKQLAQIEMDLK 146
                                    :|..::|.|:|||||||:||.|.::.|.|:||:.||:.|||
  Fly   522 SSSQGRSSPDTDPAEPPEFPLSPAELPQYLTRFQWDMAKYPIKQSLRNIADIISKQIGQIDGDLK 586

Human   147 SRTAAYNTLKTNLENLEKKSMGNLFTRTLSDIVSKEDFVLDSEYLVTLLVIVPKPNYSQWQKTYE 211
            :::.|||.||.||:|||||..|:|.||.|:|:|.||.|:||||||.||||||||...:.|...||
  Fly   587 TKSQAYNNLKGNLQNLEKKKTGSLLTRNLADLVKKEHFILDSEYLTTLLVIVPKVMANDWLTNYE 651

Human   212 SLSDMVVPRSTKLITEDKEGGLFTVTLFRKVIEDFKTKAKENKFTVREFYYDEKEIEREREEMAR 276
            .::||:||||::||.||.:..||.||||:||.|:||..|:|.||.||:|.|:|:|:...:.||.:
  Fly   652 KITDMIVPRSSQLIQEDADYCLFNVTLFKKVAEEFKLHARERKFIVRDFVYNEEELAAGKNEMTK 716

Human   277 LLSDKKQQYQTSCVALKKGSSTFPDHKVKVTPLGNPDRPAAGQTDRERESEGEGEGPLLRWLKVN 341
            |::|||:|:                                              |||:||||||
  Fly   717 LMTDKKKQF----------------------------------------------GPLVRWLKVN 735

Human   342 FSEAFIAWIHIKALRVFVESVLRYGLPVNFQAVLLQPHKKSSTKRLREVLNSVFRHLDEVAATSI 406
            |||||.|.||:|||||||||||||||||||||:|::|:|| |.||||:|||.::.|||..:|...
  Fly   736 FSEAFCALIHVKALRVFVESVLRYGLPVNFQAILIEPNKK-SVKRLRDVLNQLYGHLDGASAGGA 799

Human   407 LDA--SVEIPGLQLNNQDYFPYVYFHIDLSLLD 437
            :.:  :|:||||.....:|||||::.:::.:::
  Fly   800 VSSADNVDIPGLGFGQSEYFPYVFYKVNIDMVE 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP6V1C2	XP_011508641.1	V-ATPase_C	5..427	CDD:397366	220/862 (26%)
		3-helical coiled coil	55..75	CDD:270211	10/19 (53%)
		3-helical coiled coil	130..156	CDD:270211	12/25 (48%)
		3-helical coiled coil	284..361	CDD:270211	25/76 (33%)
Vha44	NP_001137679.1	V-ATPase_C	6..>98	CDD:301617	52/91 (57%)
		3-helical coiled coil	57..77	CDD:270211	10/19 (53%)
		V-ATPase_C	<547..822	CDD:281248	161/321 (50%)
		3-helical coiled coil	570..596	CDD:270211	12/25 (48%)
		3-helical coiled coil	724..755	CDD:270211	25/76 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159388
Domainoid	1	1.000	381	1.000	Domainoid score	I844
eggNOG	1	0.900	-	-		E1_COG5127
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1016088at2759
OrthoFinder	1	1.000	-	-		FOG0001981
OrthoInspector	1	1.000	-	-		otm42041
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10137
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1630
SonicParanoid	1	1.000	-	-		X1294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.840