Protein Alignment ATP6V1C2 and vma5

DIOPT Version :9

• Sequence 1: XP_011508641.1
• Gene: ATP6V1C2 / 245973
• HGNCID: 18264
• Length: 437
• Species: Homo sapiens
• Sequence 2: NP_593891.1
• Gene: vma5 / 2543469
• PomBaseID: SPAPB2B4.05
• Length: 394
• Species: Schizosaccharomyces pombe
• Alignment Length: 445
• Identity: 131/445 - (29%)
• Similarity: 227/445 - (51%)
• Gaps: 76/445 - (17%)

Human     2 SEFWLISAP---GDKENL-QALERMNTVTSKSNLSYNTKFAIPDFKVGTLDSLVGLSDELGKLDT 62
            |:||::|.|   |...:| ..:||:....|.|.:|....|.:|.|||.:||.|:..|::|.|.|.
pombe     4 SDFWILSVPSRGGSNADLCDDIERLLVSGSTSLISTVAPFDVPPFKVESLDVLISQSEQLTKQDA 68

Human    63 FAESLIRRMAQSVVEVMEDSKGKVQEHLLANGGLKGKMKCLKIDLTSFVTHFEWDMAKYPVKQPL 127
            ...|.|.:::..:...:..|.|.::::.:...  |..::        :|:.|.|:.:::.:.:.:
pombe    69 QCASAISKISDIIKNTVSSSSGDLKDYFMVQD--KSPLE--------YVSSFAWNSSRFHMNKTI 123

Human   128 VSVVDTIAKQLAQIEMDLKSRTAAYNTLKTNLENLEKKSMGNLFTRTLSDIVSKEDFVLDSEYLV 192
            ..:.|.|..::...|.|:::|..::....:..:|::||..|||..::|::||.:||.|..|:||.
pombe   124 SEISDRITSEIISFENDIRTRQTSFQQASSAFQNMQKKQSGNLSQKSLANIVHEEDVVHGSDYLT 188

Human   193 TLLVIVPKPNYSQWQKTYESLSDMVVPRSTKLITEDKEGGLFTVTLFRKVIEDFKTKAKENKFTV 257
            .:.:.||.....|:..:||:|:|:|:|||.|.:.:|.|..|:||.:|:|..:.|.|||:|.|:|:
pombe   189 NVFIAVPLNLEKQFLNSYETLTDLVIPRSAKKLDQDSEFVLYTVVVFKKTADSFITKAREAKYTI 253

Human   258 REFYYDEKEIEREREEMARLLSDKKQQYQTSCVALKKGSSTFPDHKVKVTPLGNPDRPAAGQTDR 322
            |||.:::...|.|:.|                         |.|..||
pombe   254 REFTFEQGLRETEQSE-------------------------FDDAAVK----------------- 276

Human   323 ERESEGEGEGPLLRWLKVNFSEAFIAWIHIKALRVFVESVLRYGLPVNFQAVLLQPHKKSSTKRL 387
                |......|||:..:.|||:|..|||:|.|.|:|||:||||||.:|.:|:.||..||..| :
pombe   277 ----EKRMLSSLLRYASIAFSESFQGWIHLKCLCVYVESILRYGLPPDFSSVIFQPMAKSEVK-I 336

Human   388 REVLNSVFRHLDE----------VAATSILDASVEIPGLQLN-NQDYFPYVYFHI 431
            :.:|.|.:.:|.:          |.:::.||.|:    ..|| :::|.|:|.|.:
pombe   337 KNILLSKYAYLAQNPVGNNKVKNVDSSAGLDESM----ADLNLDEEYLPFVLFTV 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP6V1C2	XP_011508641.1	V-ATPase_C	5..427	CDD:397366	127/436 (29%)
		3-helical coiled coil	55..75	CDD:270211	5/19 (26%)
		3-helical coiled coil	130..156	CDD:270211	5/25 (20%)
		3-helical coiled coil	284..361	CDD:270211	19/76 (25%)
vma5	NP_593891.1	COG5127	1..394	CDD:227456	131/445 (29%)
		3-helical coiled coil	61..81	CDD:270211	5/19 (26%)
		3-helical coiled coil	126..152	CDD:270211	5/25 (20%)
		3-helical coiled coil	280..311	CDD:270211	14/30 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	216	1.000	Domainoid score	I660
eggNOG	1	0.900	-	-		E1_COG5127
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I1051
OMA	1	1.010	-	-		QHG54067
OrthoFinder	1	1.000	-	-		FOG0001981
OrthoInspector	1	1.000	-	-		otm53952
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10137
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1630
SonicParanoid	1	1.000	-	-		X1294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.960