Protein Alignment ATP6V1C2 and vha-11

DIOPT Version :10

• Sequence 1: XP_047299813.1
• Gene: ATP6V1C2 / 245973
• HGNCID: 18264
• Length: 484
• Species: Homo sapiens
• Sequence 2: NP_001023451.1
• Gene: vha-11 / 177017
• WormBaseID: WBGene00006920
• Length: 384
• Species: Caenorhabditis elegans
• Alignment Length: 396
• Identity: 160/396 - (40%)
• Similarity: 237/396 - (59%)
• Gaps: 52/396 - (13%)

Human     3 EFWLISAPGDKENLQALERMNTVTSKSNLSYNTKFAIPDFKVGTLDSLVGLSDELGKLDTFAESL 67
            |:||||.||:|....|.:::|  .|..|.|.|:|:.|||.||||||.||||||:|.||||.||::
 Worm     8 EYWLISVPGEKGANDAWDKLN--RSTGNTSTNSKYLIPDLKVGTLDQLVGLSDDLSKLDTSAEAV 70

Human    68 IRRMAQSVVEVMEDSKGKVQEHLLANGGLKGKMKCLKIDLTSFVTHFEWDMAKYPVKQPLVSVVD 132
            ||::.|...||:|:.|.|:.|:|:.  |.|        |:.::||.|:|:.||||:||.|..:.:
 Worm    71 IRKLVQYFTEVLEEDKSKIAENLVI--GNK--------DMKTYVTKFQWEGAKYPLKQSLKVLSE 125

Human   133 TIAKQLAQIEMDLKSRTAAYNTLKTNLENLEKKSMGNLFTRTLSDIVSKEDFVLDSEYLVTLLVI 197
            .|.||::||:.|||.::..||.||..|.::::|::|:|.|:.|:|:|..:||||:||||.|::|:
 Worm   126 IIGKQISQIDNDLKVKSLTYNNLKNALASMDRKTVGSLLTKDLADLVKADDFVLNSEYLQTVIVV 190

Human   198 VPKPNYSQWQKTYESLSDMVVPRSTKLITEDKEGGLFTVTLFRKVIEDFKTKAKENKFTVREFYY 262
            |||.:..:|::.|.:||.||||.|:||:||:.|..|:|||||:|||::||..|:||||.||:|.|
 Worm   191 VPKISVKEWEQKYATLSSMVVPGSSKLLTEEGEHALYTVTLFKKVIDEFKNTARENKFIVRDFVY 255

Human   263 DEKEIEREREEMARLLSDKKQQYQTSCVALK-------------KGSSTFPDHKVKVTPLGNP-- 312
            ||:.::..|.|..:|:::|::||......||             |....|.:   .|...|.|
 Worm   256 DEETLKAGRTERDKLMAEKQRQYAPLIRWLKINFGEIFAAYIHIKALRVFVE---SVLRYGLPVN 317

Human   313 -----DRPAAGQTDRERES--------EGEGEVSNAPGTPGSLAHISSPAQAPSG--KMNPCIFL 362
                 ..||.||..:.|:.        :|     :|.|...:|.  .|||....|  :..|.:|.
 Worm   318 FQAAVIEPAKGQQKKLRQELHKLYIHLDG-----SAAGPIDTLE--DSPALMSLGVNEYYPYVFF 375

Human   363 FSNMAF 368
            ..|:.|
 Worm   376 KLNIDF 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP6V1C2	XP_047299813.1	V-ATPase_C	4..>285	CDD:460851	133/280 (48%)
		3-helical coiled coil	55..75	CDD:270211	11/19 (58%)
		3-helical coiled coil	130..156	CDD:270211	10/25 (40%)
vha-11	NP_001023451.1	V-ATPase_C	9..373	CDD:460851	156/385 (41%)
		3-helical coiled coil	58..78	CDD:270211	11/19 (58%)
		3-helical coiled coil	123..149	CDD:270211	10/25 (40%)
		3-helical coiled coil	277..308	CDD:270211	6/33 (18%)