Protein Alignment ATP6V1C2 and vha-11

DIOPT Version :9

• Sequence 1: XP_011508641.1
• Gene: ATP6V1C2 / 245973
• HGNCID: 18264
• Length: 437
• Species: Homo sapiens
• Sequence 2: NP_001023451.1
• Gene: vha-11 / 177017
• WormBaseID: WBGene00006920
• Length: 384
• Species: Caenorhabditis elegans
• Alignment Length: 436
• Identity: 193/436 - (44%)
• Similarity: 280/436 - (64%)
• Gaps: 61/436 - (13%)

Human     3 EFWLISAPGDKENLQALERMNTVTSKSNLSYNTKFAIPDFKVGTLDSLVGLSDELGKLDTFAESL 67
            |:||||.||:|....|.:::|  .|..|.|.|:|:.|||.||||||.||||||:|.||||.||::
 Worm     8 EYWLISVPGEKGANDAWDKLN--RSTGNTSTNSKYLIPDLKVGTLDQLVGLSDDLSKLDTSAEAV 70

Human    68 IRRMAQSVVEVMEDSKGKVQEHLLANGGLKGKMKCLKIDLTSFVTHFEWDMAKYPVKQPLVSVVD 132
            ||::.|...||:|:.|.|:.|:|:.  |.|        |:.::||.|:|:.||||:||.|..:.:
 Worm    71 IRKLVQYFTEVLEEDKSKIAENLVI--GNK--------DMKTYVTKFQWEGAKYPLKQSLKVLSE 125

Human   133 TIAKQLAQIEMDLKSRTAAYNTLKTNLENLEKKSMGNLFTRTLSDIVSKEDFVLDSEYLVTLLVI 197
            .|.||::||:.|||.::..||.||..|.::::|::|:|.|:.|:|:|..:||||:||||.|::|:
 Worm   126 IIGKQISQIDNDLKVKSLTYNNLKNALASMDRKTVGSLLTKDLADLVKADDFVLNSEYLQTVIVV 190

Human   198 VPKPNYSQWQKTYESLSDMVVPRSTKLITEDKEGGLFTVTLFRKVIEDFKTKAKENKFTVREFYY 262
            |||.:..:|::.|.:||.||||.|:||:||:.|..|:|||||:|||::||..|:||||.||:|.|
 Worm   191 VPKISVKEWEQKYATLSSMVVPGSSKLLTEEGEHALYTVTLFKKVIDEFKNTARENKFIVRDFVY 255

Human   263 DEKEIEREREEMARLLSDKKQQYQTSCVALKKGSSTFPDHKVKVTPLGNPDRPAAGQTDRERESE 327
            ||:.::..|.|..:|:::|::||
 Worm   256 DEETLKAGRTERDKLMAEKQRQY------------------------------------------ 278

Human   328 GEGEGPLLRWLKVNFSEAFIAWIHIKALRVFVESVLRYGLPVNFQAVLLQPHKKSSTKRLREVLN 392
                .||:||||:||.|.|.|:||||||||||||||||||||||||.:::| .|...|:||:.|:
 Worm   279 ----APLIRWLKINFGEIFAAYIHIKALRVFVESVLRYGLPVNFQAAVIEP-AKGQQKKLRQELH 338

Human   393 SVFRHLDEVAATSILDASVEIPGL-QLNNQDYFPYVYFHIDLSLLD 437
            .::.|||..||..| |...:.|.| .|...:|:|||:|.:::..|:
 Worm   339 KLYIHLDGSAAGPI-DTLEDSPALMSLGVNEYYPYVFFKLNIDFLN 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP6V1C2	XP_011508641.1	V-ATPase_C	5..427	CDD:397366	188/422 (45%)
		3-helical coiled coil	55..75	CDD:270211	11/19 (58%)
		3-helical coiled coil	130..156	CDD:270211	10/25 (40%)
		3-helical coiled coil	284..361	CDD:270211	23/76 (30%)
vha-11	NP_001023451.1	V-ATPase_C	10..373	CDD:281248	188/422 (45%)
		3-helical coiled coil	58..78	CDD:270211	11/19 (58%)
		3-helical coiled coil	123..149	CDD:270211	10/25 (40%)
		3-helical coiled coil	277..308	CDD:270211	23/76 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161471450
Domainoid	1	1.000	428	1.000	Domainoid score	I329
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	437	1.000	Inparanoid score	I1037
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54067
OrthoDB	1	1.010	-	-		D1016088at2759
OrthoFinder	1	1.000	-	-		FOG0001981
OrthoInspector	1	1.000	-	-		otm16166
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10137
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1630
SonicParanoid	1	1.000	-	-		X1294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.040