Protein Alignment ATP6V1C2 and atp6v1c2

DIOPT Version :9

• Sequence 1: XP_011508641.1
• Gene: ATP6V1C2 / 245973
• HGNCID: 18264
• Length: 437
• Species: Homo sapiens
• Sequence 2: XP_002940167.1
• Gene: atp6v1c2 / 100485790
• XenbaseID: XB-GENE-962058
• Length: 381
• Species: Xenopus tropicalis
• Alignment Length: 437
• Identity: 274/437 - (62%)
• Similarity: 334/437 - (76%)
• Gaps: 57/437 - (13%)

Human     1 MSEFWLISAPGDKENLQALERMNTVTSKSNLSYNTKFAIPDFKVGTLDSLVGLSDELGKLDTFAE 65
            |||.||||.||||.||.||:||||||||:|||.|.||.||:.||||||:||||||||||||.:||
 Frog     1 MSELWLISVPGDKTNLTALDRMNTVTSKANLSSNAKFVIPELKVGTLDALVGLSDELGKLDAYAE 65

Human    66 SLIRRMAQSVVEVMEDSKGKVQEHLLANGGLKGKMKCLKIDLTSFVTHFEWDMAKYPVKQPLVSV 130
            |||:::||.:.|||:||..|.||:|||||          :||.|::..||||||||||||||.::
 Frog    66 SLIKKIAQYIGEVMDDSTDKAQENLLANG----------VDLISYLARFEWDMAKYPVKQPLKNI 120

Human   131 VDTIAKQLAQIEMDLKSRTAAYNTLKTNLENLEKKSMGNLFTRTLSDIVSKEDFVLDSEYLVTLL 195
            ::.::||::||:.|||||::|||.:|.:|::||:|::|||.||||:|||:|||||||||||||||
 Frog   121 MEVLSKQMSQIDTDLKSRSSAYNNIKGSLQSLERKTVGNLLTRTLADIVNKEDFVLDSEYLVTLL 185

Human   196 VIVPKPNYSQWQKTYESLSDMVVPRSTKLITEDKEGGLFTVTLFRKVIEDFKTKAKENKFTVREF 260
            |:|||.:|..||||||||||||||||||:|.||.|||||||||||||::|||.||:||||.||||
 Frog   186 VVVPKSSYGAWQKTYESLSDMVVPRSTKMIAEDAEGGLFTVTLFRKVMDDFKAKARENKFIVREF 250

Human   261 YYDEKEIEREREEMARLLSDKKQQYQTSCVALKKGSSTFPDHKVKVTPLGNPDRPAAGQTDRERE 325
            .::|||::.|:.|:.:|.:||||.|
 Frog   251 LFNEKELQSEKAEIVKLAADKKQLY---------------------------------------- 275

Human   326 SEGEGEGPLLRWLKVNFSEAFIAWIHIKALRVFVESVLRYGLPVNFQAVLLQPHKKSSTKRLREV 390
                  ||||||||||||||||.||||||||||||||||||||||||||:|||:|| |.||||:|
 Frog   276 ------GPLLRWLKVNFSEAFIGWIHIKALRVFVESVLRYGLPVNFQAVVLQPNKK-SMKRLRDV 333

Human   391 LNSVFRHLDEVAATSILDASVEIPGLQLNNQDYFPYVYFHIDLSLLD 437
            ||::||||||.||.::.|..:|||||||::|||:|||.|.|||:.||
 Frog   334 LNAIFRHLDENAAANMKDIGMEIPGLQLSSQDYYPYVCFKIDLTNLD 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP6V1C2	XP_011508641.1	V-ATPase_C	5..427	CDD:397366	263/421 (62%)
		3-helical coiled coil	55..75	CDD:270211	14/19 (74%)
		3-helical coiled coil	130..156	CDD:270211	12/25 (48%)
		3-helical coiled coil	284..361	CDD:270211	28/76 (37%)
atp6v1c2	XP_002940167.1	V-ATPase_C	5..370	CDD:367405	263/421 (62%)
		3-helical coiled coil	55..75	CDD:270211	14/19 (74%)
		3-helical coiled coil	120..146	CDD:270211	12/25 (48%)
		3-helical coiled coil	274..305	CDD:270211	28/76 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	525	1.000	Domainoid score	I3337
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H15866
Inparanoid	1	1.050	540	1.000	Inparanoid score	I7166
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1016088at2759
OrthoFinder	1	1.000	-	-		FOG0001981
OrthoInspector	1	1.000	-	-		oto154857
Panther	1	1.100	-	-	LDO	PTHR10137
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1630
SonicParanoid	1	1.000	-	-		X1294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.190