DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ncam1 and DIP-epsilon

DIOPT Version :9

Sequence 1:	XP_038936733.1	Gene:	Ncam1 / 24586	RGDID:	67378	Length:	1136	Species:	Rattus norvegicus
Sequence 2:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster

Alignment Length:	571	Identity:	120/571 - (21%)
Similarity:	188/571 - (32%)	Gaps:	185/571 - (32%)

- Green bases have known domain annotations that are detailed below.

  Rat   182 TDEGTYRCEGRILARGEINFKDIQVIVNVPPTVQARQSIVNATANLGQSVTLVCDADGFPEPTMS 246
            ||.|:   ||.   .|.:....:..:::..|  :....|.|.|...|::|.|.|.........::
  Fly    28 TDTGS---EGN---AGNVGGSTLNNVISEDP--EFTDVIENITVPAGRNVKLACSVKNLGSYKVA 84

  Rat   247 W----------------TKDGE-PIENEEEDDEKHIFSDDSSELTIRNVDKNDEAEYVC-----I 289
            |                |::.. .:.:::.|..:..|      |.|.||.:.|...|:|     .
  Fly    85 WMHFEQSAILTVHNHVITRNPRISVTHDKHDKHRTWF------LHINNVQEEDRGRYMCQINTVT 143

  Rat   290 AENKAGEQDASIHLKVFAKPKI--TYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSE 352
            |:.:.|      .:||...|.|  ....:...:...:.|||.|:|.|.|.|:|.|:....|
  Fly   144 AKTQYG------FVKVVVPPNIDDALTSSDIIVREGDNVTLRCKAKGSPEPTIKWKRDDGN---- 198

  Rat   353 EKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQD-SQSMYLEVQYA 416
                  :....:||:.|     .....||.|:.|.....|.|:|.|||.:... |:.:.:.|.::
  Fly   199 ------KIVINKTLEVH-----DLETDSLELERISRLHMGAYLCIASNGVPPSVSKRIKVSVDFS 252

  Rat   417 PKLQGPVAVYTWEGNQV-------NITCEVF--AYPSATISWFR--DGQLLPSSNYSNIKIYNTP 470
            |.:        |..:|:       |||.|.|  |.|::...|.|  |..:..||.|....|...|
  Fly   253 PMV--------WIPHQLVGIPIGFNITLECFIEANPTSLNYWTRENDQMITESSKYKTETIPGHP 309

  Rat   471 S---ASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDRVEPYSSTAQVQFDE 532
            |   ...|.:|....:|:|||.|.|.|..|.......|..    |||...:..|.::|.:    .
  Fly   310 SYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYM----SSPPTTQPPPTTTTLR----R 366

  Rat   533 PEATGGVPILKYKAEWKSLGEEAWHSKWYDAKEANMEGIVTIMGLKPETRYAVRLAALNGKGLGE 597
            ...|                          |.|..::|.:.              ..|||.|:|.
  Fly   367 TTTT--------------------------AAEIALDGYIN--------------TPLNGNGIGI 391

  Rat   598 ISAATEFKTQPVHSPPPQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVKYRAKLASE 662
            :...      |.:|....|:.|                                 :||.:.|...
  Fly   392 VGEG------PTNSVIASGKSS---------------------------------IKYLSNLNEI 417

  Rat   663 WKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQP 713
            .|.:.:|...|.    |..||:            :|||..:|.....|:.|
  Fly   418 DKSKQKLTGSSP----KGFDWS------------KGKSSGSHGNLMASSWP 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ncam1	XP_038936733.1	IgI_1_NCAM-1	20..116	CDD:409451
		Ig strand B	37..41	CDD:409451
		Ig strand C	51..55	CDD:409451
		Ig strand E	79..83	CDD:409451
		Ig strand F	93..98	CDD:409451
		Ig strand G	107..110	CDD:409451
		IG_like	124..190	CDD:214653	3/7 (43%)
		Ig strand B	135..139	CDD:409353
		Ig strand C	148..152	CDD:409353
		Ig strand E	172..176	CDD:409353
		Ig strand F	186..191	CDD:409353	0/4 (0%)
		IgI_3_NCAM-1	211..308	CDD:143207	23/118 (19%)
		Ig strand B	231..235	CDD:143207	2/3 (67%)
		Ig strand C	244..248	CDD:143207	1/19 (5%)
		Ig strand E	271..275	CDD:143207	1/3 (33%)
		Ig strand F	285..290	CDD:143207	2/9 (22%)
		Ig strand G	298..301	CDD:143207	0/2 (0%)
		IgI_NCAM-1	307..413	CDD:143277	27/108 (25%)
		Ig strand B	326..330	CDD:143277	3/3 (100%)
		Ig strand C	339..343	CDD:143277	1/3 (33%)
		Ig strand E	379..383	CDD:143277	2/3 (67%)
		Ig strand F	393..398	CDD:143277	2/4 (50%)
		Ig strand G	406..409	CDD:143277	1/2 (50%)
		Ig_3	422..494	CDD:404760	26/85 (31%)
		Ig strand B	433..437	CDD:409353	2/10 (20%)
		Ig strand C	446..450	CDD:409353	0/3 (0%)
		Ig strand E	473..477	CDD:409353	1/3 (33%)
		Ig strand F	487..492	CDD:409353	3/4 (75%)
		FN3	509..606	CDD:238020	14/96 (15%)
		fn3	619..701	CDD:394996	12/81 (15%)
		Herpes_BLLF1	<842..1133	CDD:282904
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	21/107 (20%)
		Ig	69..139	CDD:143165	14/75 (19%)
		IG_like	165..249	CDD:214653	25/98 (26%)
		IGc2	172..237	CDD:197706	24/79 (30%)
		IG_like	267..348	CDD:214653	26/80 (33%)
		Ig	270..339	CDD:299845	24/68 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910