DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ncam1 and Fas2

DIOPT Version :9

Sequence 1:	XP_038936733.1	Gene:	Ncam1 / 24586	RGDID:	67378	Length:	1136	Species:	Rattus norvegicus
Sequence 2:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster

Alignment Length:	827	Identity:	218/827 - (26%)
Similarity:	354/827 - (42%)	Gaps:	124/827 - (14%)

- Green bases have known domain annotations that are detailed below.

  Rat    10 TLFFLGTAVSLQVDIVPSQGEIS---VGESKFFLCQ--VAGDAKDKDISWF---------SPNGE 60
            :|..|..|.|..::|.|.| |:.   ||:.....|:  |...:...|:.|.         .|||.
  Fly    21 SLIELTRAQSPILEIYPKQ-EVQRKPVGKPLILTCRPTVPEPSLVADLQWKDNRNNTILPKPNGR 84

  Rat    61 KLSPNQQRISVVWNDDDSSTLTIYNANIDDAGIYKCVVTAEDGTQSEATVNVKIFQKLMFKNAPT 125
                ||..:.......:|..|.|.:.:::..|.|.|..:..:....|..|.:|.:..:.:.|||.
  Fly    85 ----NQPPMYTETLPGESLALMITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVAITWTNAPE 145

  Rat   126 PQEFKEGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE 190
            .|....|:|.|::|:|.:...|||.|...| |.|...:.:::|.:|..| ||.::::|||.|.|.
  Fly   146 NQYPTLGQDYVVMCEVKADPNPTIDWLRNG-DPIRTTNDKYVVQTNGLL-IRNVQESDEGIYTCR 208

  Rat   191 GRILARGEINFKDIQVIVNVPPTVQARQSIVNATANL----GQSVTLVCDADGFPEPTMSWTKDG 251
            ..::..||:..:.|:|.|.:.|      .|::...||    |:.....|.|.|.|.|.:||.:|.
  Fly   209 AAVIETGELLERTIRVEVFIQP------EIISLPTNLEAVEGKPFAANCTARGKPVPEISWIRDA 267

  Rat   252 EPIENEEEDDEKHIFSDDSSELTIRNVDKNDEAEYVCIAENKAGEQDASIHLKVFAKPKITYVEN 316
            ..:.....|  :...:..:..:||.:|.::|...|.|:|:|:||..|....|.|..:|:|..:.|
  Fly   268 TQLNVATAD--RFQVNPQTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNVLVRPQIYELYN 330

  Rat   317 QTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEK----QETLDGHMVVRSH-- 375
            .|....:| :.:||.|.|.|.|:||:|            .|...|:    |:..|..:::..:
  Fly   331 VTGARTKE-IAITCRAKGRPAPAITFR------------RWGTQEEYTNGQQDDDPRIILEPNFD 382

  Rat   376 ----ARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAP---KLQGPVAVYTWEGNQV 433
                ....:|.:.:.:.:|.|.|.|.|.|......::.::.|::||   .::....|::||..:.
  Fly   383 EERGESTGTLRISNAERSDDGLYQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSWEQRKA 447

  Rat   434 NITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQ 498
            |::|.....|:|||.|..:|:.:.....:|:||..|...|.|.|.|.:...:..|.|.|.|..|.
  Fly   448 NLSCLAMGIPNATIEWHWNGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGT 512

  Rat   499 ESLEFILVQADTPSSPSIDRVEPYSSTA-QVQFD--EPEATGGVPILKYKAEWKSLGEEAWHSKW 560
            ...:..|.:|..|.  .:...:|...|| .:.||  .|....|:|||.|..::|    ||.:..|
  Fly   513 AEHDMQLKEARVPD--FVSEAKPSQLTATTMTFDIRGPSTELGLPILAYSVQYK----EALNPDW 571

  Rat   561 YDA--KEANMEGIVTIMGLKPETRYAVRLAALNGKGLGEISAATEFKT---------QPVHSP-- 612
            ..|  :..:.:....:.||:|:|.|:.|.||.|..|||......:..|         :|:|:|
  Fly   572 STAYNRSWSPDSPYIVEGLRPQTEYSFRFAARNQVGLGNWGVNQQQSTPRRSAPEEPKPLHNPVQ 636

  Rat   613 -----PPQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVKY--RAKLASEWKPEIRLP 670
                 |....|.:...|.:.|...           |.|.||..|.:||  ..|::..| .|:...
  Fly   637 HDKEEPVVVSPYSDHFELRWGVPA-----------DNGEPIDRYQIKYCPGVKISGTW-TELENS 689

  Rat   671 SGSDHVM------LKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTAGLSTG 729
            ..:..||      :..|..|..|.:.:.|.|..|.|..|..:.:|:.....|..  :.....|:.
  Fly   690 CNTVEVMETTSFEMTQLVGNTYYRIELKAHNAIGYSSPASIIMKTTRGIDVIQV--AERQVFSSA 752

  Rat   730 AIVGILIVIFVLLLVVMDITCYFLNKCGLLMCIAVN------LCGKA 770
            |||||.|...:|||.|:|:.|          ||.|:      :|.||
  Fly   753 AIVGIAIGGVLLLLFVVDLLC----------CITVHMGVMATMCRKA 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ncam1	XP_038936733.1	IgI_1_NCAM-1	20..116	CDD:409451	24/109 (22%)
		Ig strand B	37..41	CDD:409451	0/3 (0%)
		Ig strand C	51..55	CDD:409451	1/3 (33%)
		Ig strand E	79..83	CDD:409451	1/3 (33%)
		Ig strand F	93..98	CDD:409451	2/4 (50%)
		Ig strand G	107..110	CDD:409451	1/2 (50%)
		IG_like	124..190	CDD:214653	23/65 (35%)
		Ig strand B	135..139	CDD:409353	1/3 (33%)
		Ig strand C	148..152	CDD:409353	2/3 (67%)
		Ig strand E	172..176	CDD:409353	1/3 (33%)
		Ig strand F	186..191	CDD:409353	2/4 (50%)
		IgI_3_NCAM-1	211..308	CDD:143207	27/100 (27%)
		Ig strand B	231..235	CDD:143207	0/3 (0%)
		Ig strand C	244..248	CDD:143207	1/3 (33%)
		Ig strand E	271..275	CDD:143207	0/3 (0%)
		Ig strand F	285..290	CDD:143207	2/4 (50%)
		Ig strand G	298..301	CDD:143207	1/2 (50%)
		IgI_NCAM-1	307..413	CDD:143277	25/115 (22%)
		Ig strand B	326..330	CDD:143277	0/3 (0%)
		Ig strand C	339..343	CDD:143277	2/3 (67%)
		Ig strand E	379..383	CDD:143277	1/3 (33%)
		Ig strand F	393..398	CDD:143277	2/4 (50%)
		Ig strand G	406..409	CDD:143277	0/2 (0%)
		Ig_3	422..494	CDD:404760	22/71 (31%)
		Ig strand B	433..437	CDD:409353	1/3 (33%)
		Ig strand C	446..450	CDD:409353	2/3 (67%)
		Ig strand E	473..477	CDD:409353	2/3 (67%)
		Ig strand F	487..492	CDD:409353	2/4 (50%)
		FN3	509..606	CDD:238020	29/101 (29%)
		fn3	619..701	CDD:394996	20/89 (22%)
		Herpes_BLLF1	<842..1133	CDD:282904
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	21/98 (21%)
		IG_like	144..226	CDD:214653	28/83 (34%)
		IGc2	152..209	CDD:197706	22/58 (38%)
		I-set	230..319	CDD:254352	26/96 (27%)
		IGc2	243..309	CDD:197706	18/67 (27%)
		IG_like	330..424	CDD:214653	23/106 (22%)
		IGc2	339..412	CDD:197706	19/84 (23%)
		Ig	447..518	CDD:143165	21/70 (30%)
		fn3	534..611	CDD:278470	27/80 (34%)
		FN3	640..735	CDD:238020	24/106 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40754
Inparanoid	1	1.050	262	1.000	Inparanoid score	I3018
OMA	1	1.010	-	-		QHG48678
OrthoDB	1	1.010	-	-		D129648at2759
OrthoFinder	1	1.000	-	-		FOG0002001
OrthoInspector	1	1.000	-	-		otm45717
orthoMCL	1	0.900	-	-		OOG6_103800
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.780