DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myh3 and didum

DIOPT Version :9

Sequence 1:NP_036736.1 Gene:Myh3 / 24583 RGDID:3138 Length:1940 Species:Rattus norvegicus
Sequence 2:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster


Alignment Length:2046 Identity:522/2046 - (25%)
Similarity:912/2046 - (44%) Gaps:470/2046 - (22%)


- Green bases have known domain annotations that are detailed below.


  Rat    44 KEEYAKGKIKSSQDGKVTVETEDNRTLVVK----PEDVYAM-NPPKFDKIEDMAMLTHLNEPAVL 103
            :|.|.||.      |.:.:.|:..:...||    ..|:..: ||.......|:..|::|:||.||
  Fly    29 EESYRKGA------GFLKICTDSGKLKEVKLKADGSDLPPLRNPAILVGQNDLTTLSYLHEPGVL 87

  Rat   104 YNLKDRYTS-WMIYTYSGLFCVTVNPYKWLPVYTPEVVDGYRGKKRQEAPPHIFSISDNAYQFML 167
            :||:.|:.. .:||||.|:..|.:|||..:|:|.|.::..|||....:..||||::::.||..:.
  Fly    88 HNLRVRFCERQIIYTYCGIILVAINPYAEMPLYGPSIIRAYRGHAMGDLEPHIFALAEEAYTKLE 152

  Rat   168 TDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFG 232
            .:..|.||:::|||||||||:.|..::|||.:..         |:.:..:|.::::::|::||||
  Fly   153 RENCNLSIIVSGESGAGKTVSAKYAMRYFAAVGG---------SESETQVERKVLASSPIMEAFG 208

  Rat   233 NAKTVRNDNSSRFGKFIRIHF-GTTGK--LASADIETYLLEKSRVTFQLKAERSYHIFYQILS-- 292
            ||||.|||||||||||.::.| ...|.  |..|.:.|||||||||.:|.:.||:||||||:.:  
  Fly   209 NAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERNYHIFYQLCAAR 273

  Rat   293 NKKPELIELLLITTNPYDYPFISQG---EILVASIDDREELLATDSAIDILGFTPEEKSGLYKLT 354
            :|.||     |:..:...:.|::.|   ||  ..:.|.|:...|..|:.:|||:.::.:.:.|:.
  Fly   274 SKYPE-----LVLDHQDKFQFLNMGGAPEI--ERVSDAEQFNETVQAMTVLGFSIQQIADIVKIL 331

  Rat   355 GAVMHYGNMKFKQKQRE--EQAEPDGTEVADK------TAYLMGLNSSDLLKALCFPRVKVGNEY 411
            ..::|.||::..:|..|  |:.:.|..::...      ||.|:.:::.||.:.|...:::..|||
  Fly   332 AGILHLGNIQVSKKFNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLLMRKIESVNEY 396

  Rat   412 VTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQ 476
            |....:::....|.:||:|.:|.|||.::|..:|:.|:....:..|||||||.|||.||.||.||
  Fly   397 VLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSLNNGSKQCSFIGVLDIYGFETFEVNSFEQ 461

  Rat   477 LCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMF 541
            .|||:.||||||.||.|:|.||||||.||||.||.||| .|...||:|||..:|:..:|:|||..
  Fly   462 FCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDF-YDNQPCIDLIESRLGVLDLLDEECRM 525

  Rat   542 PKATDTSFKNKLYDQHLGKSN---NFQKPKVVKGKAEAHFSLIHYAGTVDYSVSGWLEKNKDPLN 603
            ||.:|.|:..||    :||.|   :|:||:.    ....|.:.|::.||:|.|:|:||||:|.::
  Fly   526 PKGSDESWAGKL----IGKCNKFPHFEKPRF----GTTSFFIKHFSDTVEYDVNGFLEKNRDTVS 582

  Rat   604 ETVVGLYQKSSNRLLAHLYATF----------ATTDADGGKKKVA---KKKGSSF---------- 645
            :.:..:..: ||..||....|.          |.:...||:..::   |::|:..          
  Fly   583 KELTQVLSE-SNMSLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGNDTRRRVVPSKQH 646

  Rat   646 -QTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKG 709
             :||.:.|:|:|..|:|.|..|.||:||||.||:.|.....|.:.::.|||..||||.:||...|
  Fly   647 RKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACGVLETVRISAAG 711

  Rat   710 FPNRILYGDFKQRYRVL-NASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGT 773
            ||:|.||.||..||::| ..|.:.:.   |.|.:|..::.....|..:|:||:|::||:||.:..
  Fly   712 FPSRWLYPDFYMRYQLLVYRSKLDKN---DMKLSCRNIVMKWIQDEDKYRFGNTQIFFRAGQVAF 773

  Rat   774 LEEMRDERLAKLITRTQAV-----------------------CRGFLMRVEFQKMMQRRESIFCI 815
            ||::|.....|.||..|:|                       .||:|.|...|||.:.|..:...
  Fly   774 LEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQKMREARAGLILS 838

  Rat   816 QYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDE----------------- 863
            :|       .:.|...:.:.:::..:...:|.......:.:|...:|.                 
  Fly   839 KY-------ARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMRDHYRAVQIQRFVRGALARR 896

  Rat   864 -------------------LAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQL 909
                               ||:.:.||.:.|.|.::.::.|      .......::..::|.|:|
  Fly   897 AYQKRRRNIIICQAAIRRFLARRKFKRMKAEAKTISHMENK------YMGLENKIISMQQRIDEL 955

  Rat   910 IKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 974
            .:....|:.|              .:|::..|.||     ||||.::      |:.:..|.|.::
  Fly   956 NRDNSNLKHK--------------TSEISVLKMKL-----ELKKTLE------AEFKNVKAACQD 995

  Rat   975 KVKNLTEELAGLDETIAKLTREKKALQEAHQQTLDDL-QAEEDKVNSLSKLKSKLEQQVDDLESS 1038
            |           |:.|..|.::.:|.::...|.|::. .|:|:.::.    |....|:.::|...
  Fly   996 K-----------DKLIEALNKQLEAERDEKMQLLEENGHAQEEWISQ----KQTWRQENEELRRQ 1045

  Rat  1039 LEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKK--KDFEYSQLQSKVEDEQTL 1101
            :::...:..:.|.|:|..| |..||       |.|.::|:|..::  ||.|.      :|:|..:
  Fly  1046 IDEIIDMAKNAEVNQRNQE-DRMLA-------EIDNRELNEAYQRAIKDKEV------IENENFM 1096

  Rat  1102 SLQLQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNK 1166
                   :||..:|:                |....|.:||:....|.:.|:..|..|.:..|:.
  Fly  1097 -------LKEELSRL----------------TAGSFSLHARKASNASSQNEDDVGYASAKNTLDI 1138

  Rat  1167 KREAEFL--------------KLRRDLEE-----ATLQHEATVATLRKKHADSAAELAEQIDNLQ 1212
            .|..:.|              |||..|||     ..||.:....:.|.|..:.:..::|      
  Fly  1139 NRPPDLLSKNYSYNDSTSLVVKLRSILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSE------ 1197

  Rat  1213 RVKQKLEKEKSEFKLEIDDLSSSVESVSKSKANLEKICRTLEDQLSEARGKNEETQRSLSELTTQ 1277
                 ||.|..:.:.|.|.|.:|:      |..:|                       ::||..|
  Fly  1198 -----LEVENEKLRSEYDQLRTSI------KHGVE-----------------------INELNAQ 1228

  Rat  1278 KSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQIEELKRQLEEENKAKNALAHALQSSRHDCD 1342
            .:.||.|......:..:.::::.|.|:|           .|.||.|         :||...:|.:
  Fly  1229 HAALQEEVRRRREECIQLKAVLLQQSQS-----------MRSLEPE---------SLQMRGNDVN 1273

  Rat  1343 LLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEA 1407
            .|.|.:..::....:|:..| ||.:|      ::.:..::.|:|:|        ||.:.:::::.
  Fly  1274 ELMEAFHSQKLINRQLESEL-KAITE------EHNSKLVEMTQEIE--------RLNNEKDELQK 1323

  Rat  1408 VNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDK-KQRNFDKVLAEWKTKCEESQAELEAA 1471
            |..:  |::        |.||..||..|.|      |: .:|...|.:|::..    .|.||:.|
  Fly  1324 VMFE--SID--------EFEDSNVDTLRQN------DRYLRRELQKAVAQFLL----VQEELKLA 1368

  Rat  1472 LKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEI-ADLTEQIAENGKSIHELEKSRKQME 1535
            ..:.::...:..:|::..||     |.::.::.....:: |::|:|.::|.:.:         |:
  Fly  1369 NAKLKAYRQDGGQLEHKIEE-----EMIRNKSNGTSADVGANVTKQKSQNPQGL---------MK 1419

  Rat  1536 LEKADIQMALEEAEAALEHE---------EAKILRIQLELTQVKSEID--RKIAEKDEEIEQLKR 1589
            ...:|:...|:...:||...         .|.::.:.:..|.:.:..|  |::..|  .:.|:|:
  Fly  1420 FHSSDLDKILQRLLSALTPRTVVGLLPGFPAYLIFMCIRYTDLTNADDDVRELLSK--FVIQIKK 1482

  Rat  1590 NYQRTVETMQGALDAEVRSRNEAIRLKKKME--GDLNE-IEIQLSHANRQAAETIKHLRSVQGQL 1651
            .: ||...::..:...|.|    |.|...|:  ||::| ::......|:|..:.. :|...:..:
  Fly  1483 MH-RTPHPIENRVIWLVNS----ITLLNLMKQYGDVDEYVKFNTEKQNQQQLKNF-NLFEYRRVI 1541

  Rat  1652 KDTQLHLDDAL----RGQEDLKEQLAIVE-------RRANLLQAEVEELRAT------------- 1692
            .|..::|..||    :|..|.|...||:.       |:|:.:::....:.|:             
  Fly  1542 LDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQAHGMRSRATSIGASSSPEHGGGPAWKQ 1606

  Rat  1693 -LEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLTQLQSE--------------- 1741
             :.|.|...|..:...||:....|:.|    .|::....:..:...|:.:               
  Fly  1607 LIGQLEHFYKQFQHFGLDNCYAEQIFH----QLLYFICAVALNCLMLRGDICMWETGMIIRYNIG 1667

  Rat  1742 -VEDASRDARNAEE--KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ 1803
             :||..|..:.:.:  .|...:...:.:.:..|.|||.            ||:.||...|..|:.
  Fly  1668 CIEDWVRSKKMSNDVLTALAPLNQVSQLLQSRKSEQDV------------QTICDLCTSLSTAQV 1720

  Rat  1804 LALKGGKKQIQKLETRIRELEFELEGEQKRNTESVKGLRKYERRVKELTYQSE--EDRKNVLRLQ 1866
            |.:....| :...|:.|..:..|      :.||.:...:..:....|.|...:  :..|.|.|..
  Fly  1721 LKVMKSYK-LDDYESEITNVFLE------KLTEKLNARQMQKSNSDEFTIDQKFIQPFKVVFRYS 1778

  Rat  1867 DLVDKLQVKVKSYKRQAEEADEQANVHLTKF 1897
            |:             :.|:.:..::::|.:|
  Fly  1779 DI-------------KLEDIELPSHLNLDEF 1796

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myh3NP_036736.1 Myosin_N 36..73 CDD:280832 6/28 (21%)
Myosin_head 88..767 CDD:278492 273/723 (38%)
MYSc_Myh3 100..767 CDD:276878 269/711 (38%)
Actin-binding 656..678 12/21 (57%)
Actin-binding 758..772 7/13 (54%)
GrpE 843..>962 CDD:295646 23/154 (15%)
Myosin_tail_1 847..1924 CDD:279860 216/1170 (18%)
RILP-like 962..1095 CDD:304877 29/135 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1260..1289 6/28 (21%)
MIT_CorA-like <1296..>1408 CDD:294313 22/111 (20%)
COG6 1373..>1506 CDD:303003 26/133 (20%)
TMPIT 1739..>1828 CDD:285135 19/106 (18%)
didumNP_724569.1 MYSc 65..778 CDD:214580 280/741 (38%)
MYSc_Myo5 84..767 CDD:276831 269/711 (38%)
IQ 900..922 CDD:197470 2/21 (10%)
GBP_C <971..1086 CDD:303769 33/148 (22%)
coiled coil 1049..1068 CDD:293879 5/19 (26%)
coiled coil 1077..1086 CDD:293879 1/8 (13%)
JAKMIP_CC3 <1190..1299 CDD:292653 33/175 (19%)
Myo5_CBD 1424..1792 CDD:271254 73/411 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

Return to query results.
Submit another query.