DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myh11 and Mhc

DIOPT Version :9

Sequence 1:XP_006245904.1 Gene:Myh11 / 24582 RGDID:3136 Length:1979 Species:Rattus norvegicus
Sequence 2:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster


Alignment Length:1941 Identity:777/1941 - (40%)
Similarity:1182/1941 - (60%) Gaps:35/1941 - (1%)


- Green bases have known domain annotations that are detailed below.


  Rat     9 DDEKFLFV--DKNFINSPMAQADWVAKKLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTV 71
            |...:|||  ::..|:.   ...:.:||..|:|.||:|:....||..|||.|.|.| :.|:...:
  Fly    12 DPTPYLFVSLEQRRIDQ---SKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGL-QGGEVRDI 72

  Rat    72 GKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSE 136
            ..:.::|:|||||.|:||||::|.||...||||||:||::.|||||||||||.:||||..|:|:.
  Fly    73 KSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTN 137

  Rat   137 KIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASS 201
            :...||:||:|:|:||||:||:|.||..||.:..:||:|.||||||||||||||||.|.|.|.:|
  Fly   138 RCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGAS 202

  Rat   202 HKGKKDSSITQGPSFAYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGA 266
            .|       |...:.:.|.||.|::|.||:||||||||||:|||||||||||||:|..||.:.||
  Fly   203 KK-------TDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGA 260

  Rat   267 NIETYLLEKSRAIRQARDERTFHIFYYLIAGAKEKMRN-DLLLESFNSYTFLSNGFVPIPAAQDD 330
            :||||||||:|.|.|...||::||||.:::|:...::: .||.::...|..:|.|.|.:.:..|.
  Fly   261 DIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDA 325

  Rat   331 EMFQETLEAMSIMGFSEEEQLAILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLVGIN 395
            |.|..|.:|..|:||:::|:..:.::.::|:.:|.:.||:....:||.........:|..|.|.:
  Fly   326 EEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCD 390

  Rat   396 VTDFTRAILTPRIKVGRDVVQKAQTKEQADFAIEALAKATYERLFRWILSRVNKALDKTHRQGAS 460
            ..:..:.:|.||||||.:.|.:.:..:|...:|.||.|..::|||:|::.:.|:.|| |.::...
  Fly   391 TAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLD-TQQKRQH 454

  Rat   461 FLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPC 525
            |:|:||||||||||.|.|||||||:|||||||.|||.||:||||||:||||:|.|||||:||..|
  Fly   455 FIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLAC 519

  Rat   526 IELIERPNNPPGVLALLDEECWFPKATDKSFVEKLCSEQ-GNHPKFQKPKQLK---DKTEFSIIH 586
            |:|||:   |.|:|::|:||..||||||::|.|||.:.. |....|||||..|   ....|:|.|
  Fly   520 IDLIEK---PMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAH 581

  Rat   587 YAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASK 651
            |||.|.||.:.||.||.|||||.|......|.:|.:.:::.|.....|..:.||        ..:
  Fly   582 YAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAK--------GGR 638

  Rat   652 TKK-GMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGI 715
            .|| |.|.||...|||||..||||||:|.|:||||||||..|:.|.:||.||:.||.||||||||
  Fly   639 GKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGI 703

  Rat   716 RICRQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTG 780
            ||||:|||||:::.:|:.||:|:....: :|....|:|..::||.::|..:.||:|.:|:|||.|
  Fly   704 RICRKGFPNRMMYPDFKMRYKIMCPKLL-QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAG 767

  Rat   781 VLAHLEEERDLKITDVIMAFQAMCRGYLARKAFTKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLF 845
            ||..:||.||.::..::...||..||||:||.|.|.|:|..|:||:|||...||:||.|.|::|:
  Fly   768 VLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLW 832

  Rat   846 TKVKPLLQVTRQEEEMQAKEEEMQKIKERQQKAESELKELEQRHTQLAEEKTLLQEQLQAETELY 910
            .||||||.|:|.|:|:...||:.:|.:|.........||||..:.:|..|||.|.:.|..|....
  Fly   833 QKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGAL 897

  Rat   911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRSQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975
            .:.:|...:|.|:|.:||..|.:::.||.:|||...||..::||..|::..|::.:|:.|...||
  Fly   898 QDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQK 962

  Rat   976 LQLEKVTAEAKIKKLEDDILVMDDQNNKLSKERKLLEERVSDLTTNLAEEEEKAKNLTKLKSKHE 1040
            .:.:|.|.:.:|:.|.|:|...|:..|||:||:|:..|........|...|:|..:|.|:|:|.|
  Fly   963 AEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLE 1027

  Rat  1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR 1105
            ..:.|||..|::|:|.|.::||.|||:|||.....|.:|||:....||:..:.:|::||.:..|:
  Fly  1028 QTLDELEDSLEREKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAK 1092

  Rat  1106 LDEEITQKNNALKKIRELEGHVSDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1170
            |::|........::|:||:..:.:|:|::::||.||.|||||:.||..|||.|...||:...:|:
  Fly  1093 LEDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATS 1157

  Rat  1171 TQQELRAKREQEVTMLKKALDEETRSHEAQVQEMRQKHTQAVEELTEQLEQFKRAKANLDKSKQT 1235
            .|.||..|||.|::.|::.|:|....||:.:..:|:||..||.|:.||::|..:.||..:|.|..
  Fly  1158 AQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNE 1222

  Rat  1236 LEKENADLAGELRVLGQAKQEVEHKKKKLEGQLQELQSKCSDGERARTELSDKVHKLQNEVESVT 1300
            ...:..||...:..:...|...|...|:|:..|.|:|||..:..|...:......||..|...:.
  Fly  1223 YYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLL 1287

  Rat  1301 GMLNEAEGKAIKLAKEVASLGSQLQDTQELLQEETRQKLNVSTKLRQLEDERNSLQDQLDEEMEA 1365
            ..|.|||.:..:|:|...||.:||:||:.|..||:|::..:..|.|.||.:.::|::|::||.|.
  Fly  1288 RQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEG 1352

  Rat  1366 KQNLERHVSTLNIQLSDSKKKLQ-DLASTIEVMEEGKKRLQKEMEGLGQQYEEKAAAYDKLEKTK 1429
            |.:|:|.:|..|.:....:.|.: |..:..|.:||.|::||..:....:..|........|||||
  Fly  1353 KADLQRQLSKANAEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTK 1417

  Rat  1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQKKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1494
            .||..|::||.:::|....:.:..|||||.||:::.|.|......|.|.|.::.|.|...|:...
  Fly  1418 QRLSTEVEDLQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFR 1482

  Rat  1495 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMRTQLEELE 1559
            |..|.||..|..|.:.|.||.|..|::||:....:.|:|:||:||:::.||.:.:|::..|||.|
  Fly  1483 LKGAYEEGQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAE 1547

  Rat  1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAA 1624
            ..|:..|:..||.::.:..::.:.:|.:|.::|:.|..|:..||.|...:..||.|.|.:|.|..
  Fly  1548 AALEQEENKVLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALR 1612

  Rat  1625 AKKKLEGDLKDLELQADSAVKGREEAIKQLRKLQAQMKDFQRELDDARASRDEIFATSKENEKKA 1689
            .|||||.|:.:||:..|.|.|...||.|.:::.|.|:||.|..|::.:.:||:.......:|::|
  Fly  1613 MKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRA 1677

  Rat  1690 KSLEAELMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN-TLQDEKRRLEARIAQLEEELE 1753
            .:|:.||.:.:..|..|:|.|:||:.|..:..|:| :.:|.:| ::...||:||:.:..|..:|:
  Fly  1678 NALQNELEESRTLLEQADRGRRQAEQELADAHEQL-NEVSAQNASISAAKRKLESELQTLHSDLD 1741

  Rat  1754 EEQGNMEAMSDRVRKATLQAEQLSNELVTERSAAQKNESARQQLERQNKELRSKLQEVEGAVKAK 1818
            |.....:...::.:||.:.|.:|::||..|:..||..|..|:.||:|.|||:.:|.|.|......
  Fly  1742 ELLNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKG 1806

  Rat  1819 LKSTVAALEAKIVQLEEQIEQEAREKQAATKLLKQKDKKLKEVLLQVEDERKMVEQYKEQAEKGN 1883
            .|..:..||.::.:||.:::.|.|....|.|.|::.::::||:..|.|::||..|:.::..:|..
  Fly  1807 GKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQ 1871

  Rat  1884 TKVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1939
            .|:|..|||:|||||.:....|..||.|:||:||.|..:...:.::..::|.|.|:
  Fly  1872 QKIKTYKRQIEEAEEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGRAGS 1927

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myh11XP_006245904.1 Myosin_N 34..71 CDD:280832 15/36 (42%)
Myosin_head 87..778 CDD:278492 342/696 (49%)
MYSc_class_II 99..778 CDD:276951 335/684 (49%)
Myosin_tail_1 855..1935 CDD:279860 363/1081 (34%)
FAM76 <997..1089 CDD:292665 36/91 (40%)
UBAN 1049..1163 CDD:301588 44/113 (39%)
BAR <1166..>1295 CDD:299863 40/128 (31%)
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 15/37 (41%)
MYSc 81..777 CDD:214580 355/715 (50%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 335/684 (49%)
Myosin_tail_1 842..1897 CDD:279860 355/1055 (34%)
V_Alix_like 1557..1877 CDD:187408 101/320 (32%)
ATP-synt_B <1671..1771 CDD:304375 29/100 (29%)
TMPIT 1739..>1825 CDD:285135 27/85 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.820

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