DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gucy2f and Gyc76C

DIOPT Version :9

Sequence 1:	NP_001007577.1	Gene:	Gucy2f / 245650	MGIID:	105119	Length:	1108	Species:	Mus musculus
Sequence 2:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster

Alignment Length:	1206	Identity:	377/1206 - (31%)
Similarity:	557/1206 - (46%)	Gaps:	250/1206 - (20%)

- Green bases have known domain annotations that are detailed below.

Mouse     6 WPFSRLLSWFAISSRLSGQHGLPSSKFLRCLCLLALLPLLRWGQALPYKIGVIGPWTCDPFFSKA 70
            |||: ||...:::.|....|    ...|....|.||...|:..|.|    .:.|
  Fly     4 WPFN-LLLLLSVAVRDCSNH----RTVLTVGYLTALTGDLKTRQGL----AISG----------- 48

Mouse    71 LPEVAAALAIERISRDKTFDRSYSFEYVILN-EDCQTSKALASFISHQQMASGFV---GPANPGF 131
                |..:|::.:::|.....:.   |:.|. .|.:....||:....:.:..|..   ||..|.:
  Fly    49 ----ALTMALDEVNKDPNLLPNV---YLDLRWNDTKGDTVLATKAITEMICDGIATIFGPEGPCY 106

Mouse   132 CEAASLLGTSWDKGIFSWACVNHELDNKHSFPTFSRTLPSPIRV---LVTVMKYFQWAHAGVISS 193
            .||  ::..|.:..:.|:.|..:...   :.|||:||.|...:|   |:.:::|:.|....::.
  Fly   107 VEA--IVSQSRNIPMISYKCAEYRAS---AIPTFARTEPPDTQVVKSLLALLRYYAWNKFSILY- 165

Mouse   194 DEDIWMHTA----------------------NRVS------------------------------ 206
             ||:|...|                      |||.
  Fly   166 -EDVWSPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVF 229

Mouse   207 -----------SALRSQGL---------PVGVVLTSGRDSQSIQKALQQIRQADRIRIIIMCMHS 251
                       |::.:.||         .|.:::.|.|:::      :.:|:.|:|..:..| ||
  Fly   230 LGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAE------KYLRRVDQITFMSNC-HS 287

Mouse   252 ALIGGETQTHFLELAHDLKMTDGT-----YVFVPYDVLLYSLPYKHSPYQVLRNNPKLREAYDAV 311
            .       .:|.::|..|.:...|     |:.....|..||   ...|:.:  ..|:|
  Fly   288 T-------ENFNQMARSLLVVASTPPTKDYIQFTKQVQKYS---SKPPFNL--EIPRL------- 333

Mouse   312 LTITVESHEKTFYEAYAEAAARGEIPEKPDSNQVSPLFGTIYNSIYFIAQAMNNAMKK------- 369
               .|||:...|...||                     ..:|:|:...|.|::..:::
  Fly   334 ---FVESNFSKFISIYA---------------------AYLYDSVKLYAWAVDKMLREETRVLTD 374

Mouse   370 --------NGRASAASLVQHSRNMQFYGFNQLIKTDSNGNGISEYVILDTNGKEWELRGT----- 421
                    ||.....:::::...|...|  ..||.|..|:....:.:|.....:|.....
  Fly   375 DVIFEVASNGTRVIDTIIKNRTYMSITG--SKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNY 437

Mouse   422 --------YTVDMETELLRFRGTPIHFP-GGRPTSADAKCWFAERKICQGGIDPALAMMVCFALL 477
                    :..:...|.....|: |.:| ||...:.:..|.|| .::|:.. |......|...:|
  Fly   438 HMVPVAYFHQGEEHPEYKLINGS-IDWPSGGEKPADEPMCGFA-NELCKKD-DTHYTSTVAAVVL 499

Mouse   478 IALLSINGFAYFIRRRINKIQL-IKGPNRILLTLEDVTFINPHFGSK-RGSRASVSFQIISEVQS 540
            ..||..:|.......|..||:| |:|    ||...|...|..:.|:: ..|.:.||........|
  Fly   500 GVLLFCSGVITMSIYRKWKIELEIEG----LLWKIDPNEIKGYSGNEIVSSPSKVSLMSAQSYGS 560

Mouse   541 GRSPRLSFSSGSLTPATYENSNIAIYEGDWVWLKKFPPGDFGDIKSIKSSASDVFEMMKDLRHEN 605
            ..:.:...|:|.|..|......:           |||..     :.|.........::::|||:|
  Fly   561 RWTNQFVTSTGRLRGAVVRIKEL-----------KFPRK-----RDISREIMKEMRLLRELRHDN 609

Mouse   606 VNPLLGFFYDSGMFAIVSEFCSRRSLEDILTNDDVKLDWMFKSSLLLDLIKGMKYLHHREFI-HG 669
            :|..:|...:.....:|:::|::.||.||:.|:|:|||.:|.:||:.||||||.|:|:.:.: ||
  Fly   610 INSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHG 674

Mouse   670 RLKSRNCVVDGRFVLKVTDYGFNDILEMLRLSEEEPSEE-----ELLWTAPELLRAPGGIRLGSF 729
            .|||.||||..|::|:|||:|.:   |:.:.:|.|...|     ..||.||||||  ..|. ||.
  Fly   675 NLKSSNCVVTSRWMLQVTDFGLH---ELRQCAENESIGEHQHYRNQLWRAPELLR--NHIH-GSQ 733

Mouse   730 AGDVYSFAIIMQEVMVRGAPFCMMDLPAKEIIDRLKMPP--------PVYRPVVSPEYAPAECLQ 786
            .||||:|||||.|:..|..||..::...|||:|.:|..|        |....::..|..|...|.
  Fly   734 KGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLA 798

Mouse   787 LMKQCWAEASEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQ 851
            .::.||||..|:||.|..|.|:.|....||..||:|.|:.|:|:|::||||::.|||..|..||.
  Fly   799 CIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKM 863

Mouse   852 KTEKLLTQMLPLSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLF 916
            |||.||.:|||.||||.|..|..|||..:||||:|||||||||.:||.|.|::||:.||||||:|
  Fly   864 KTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVF 928

Mouse   917 DAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRI 981
            |.||..:||||||||||||||.||||.:||.|||.|||:|:|::|.:|...::.|.|...:::||
  Fly   929 DRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRI 993

Mouse   982 GLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQTLSEGYEVELRGR 1046
            |:|:||||||||||||||||||||||||||||||.|...:||:|......|..|..||..|.||.
  Fly   994 GMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGL 1058

Mouse  1047 TELKGKGTEETFWLVG------KKGFTKPLPVPPPV 1076
            ..:||||...|:||.|      :|.....:.:|||:
  Fly  1059 VNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPL 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gucy2f	NP_001007577.1	PBP1_sensory_GC_DEF-like	54..435	CDD:380594	79/492 (16%)
		PKc_like	545..815	CDD:419665	100/283 (35%)
		HNOBA	<824..869	CDD:400168	26/44 (59%)
		CYCc	848..1040	CDD:214485	121/191 (63%)
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	85/499 (17%)
		ANF_receptor	48..412	CDD:279440	75/440 (17%)
		PK_GC-A_B	543..827	CDD:270944	104/305 (34%)
		HNOBA	<835..881	CDD:285003	26/45 (58%)
		CYCc	860..1052	CDD:214485	121/191 (63%)
		Guanylate_cyc	887..1074	CDD:278633	116/186 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810