DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lpl and CG6295

DIOPT Version :9

Sequence 1:	NP_036730.1	Gene:	Lpl / 24539	RGDID:	3017	Length:	474	Species:	Rattus norvegicus
Sequence 2:	NP_651521.1	Gene:	CG6295 / 43247	FlyBaseID:	FBgn0039471	Length:	338	Species:	Drosophila melanogaster

Alignment Length:	347	Identity:	102/347 - (29%)
Similarity:	151/347 - (43%)	Gaps:	75/347 - (21%)

- Green bases have known domain annotations that are detailed below.

  Rat    25 VAAADG-----GRDFSD--IESK-------------FALRTPEDTAEDTCHLIPGLADSVSNCHF 69
            |..|||     .|:|::  :|:|             |.|.|  ::..::...|...:.|:|..||
  Fly    30 VPQADGTMEWMDREFAEAYLETKNRMEGRNVLNPVTFYLYT--NSNRNSPQEIKATSASISGSHF 92

  Rat    70 NHSSKTFVVIHGWTVT-------GMYESWVPKLVAALYKREPDSNVIVVDWLYRAQQHYPVSAGY 127
            |.:..|...||||:.:       |:.::|.         ...|.|:|.|||.......|..|...
  Fly    93 NPNHPTRFTIHGWSSSKDEFINYGVRDAWF---------THGDMNMIAVDWGRARSVDYASSVLA 148

  Rat   128 TKLVGNDVARFINWLEEEFNYPLDNVHLLGYSLGAHAAGVAG-SLTNKKVNRITGLDPAGPNFEY 191
            ...||..||..||::.......|||..::|:|||||.:|.|| ::.|.:::.|.|||||.|.|.|
  Fly   149 VPGVGEQVATLINFMRSNHGLNLDNTMVIGHSLGAHVSGYAGKNVKNGQLHTIIGLDPALPLFSY 213

  Rat   192 AEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAEKG 256
            .....|||..||.:|:.:.|     .|.::|..||:|....|||||..||||.
  Fly   214 DSPNKRLSSTDAYYVESIQT-----NGGTLGFLKPIGKGAFYPNGGKSQPGCG------------ 261

  Rat   257 LGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCNSKEAFEKGLCLSCRKNRCNNVGYEINKVR 321
               ||....|:|.||:..:.:|:  .||.....||..   :|:.:...|..:      |...::.
  Fly   262 ---VDLTGSCAHSRSVIYYAESV--TENNFPTMRCGD---YEEAVAKECGSS------YSSVRMG 312

  Rat   322 AKRSSKM-----YLKTRSQMPY 338
            |..::.|     |:..||..||
  Fly   313 ATTNAYMVAGDYYVPVRSDAPY 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpl	NP_036730.1	Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	32..53		7/35 (20%)
		lipo_lipase	33..472	CDD:132274	97/334 (29%)
		Pancreat_lipase_like	37..334	CDD:238363	92/322 (29%)
		Essential for determining substrate specificity. /evidence=ECO:0000250\|UniProtKB:P06858	243..266		3/22 (14%)
		PLAT_LPL	341..465	CDD:238856
		Important for interaction with lipoprotein particles. /evidence=ECO:0000250\|UniProtKB:P06858	417..421
		Important for heparin binding. /evidence=ECO:0000250\|UniProtKB:P06858	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	443..467
CG6295	NP_651521.1	Pancreat_lipase_like	64..330	CDD:238363	90/307 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338985
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940