| Sequence 1: | NP_036728.2 | Gene: | Lepr / 24536 | RGDID: | 3001 | Length: | 1162 | Species: | Rattus norvegicus |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001284756.1 | Gene: | sdk / 31017 | FlyBaseID: | FBgn0021764 | Length: | 2265 | Species: | Drosophila melanogaster |
| Alignment Length: | 1288 | Identity: | 244/1288 - (18%) |
|---|---|---|---|
| Similarity: | 423/1288 - (32%) | Gaps: | 456/1288 - (35%) |
- Green bases have known domain annotations that are detailed below.
|
Rat 38 APPSTTDDSFLSPAGVPNNTSSL--KGASEAL---------VEAKFNSTGIYVSELSKTIFH--- 88
Rat 89 -----------CCFGNEQGQNCS-------ALTG----NTEGKTLASVVKPLVFRQ--------L 123
Rat 124 GVNWDIECW-MKGDLTLFICHMEPLL-----KNPFKNYDSK--------------VHLLYDLPEV 168
Rat 169 IDDLPLPPLKDSFQTVQCNCSVQECEC-------H----------VPVPRAKVNYAL-------L 209
Rat 210 MYLEITSA-----------------GVSFQSPLMSLQPMLVVKPDPPLGLRMEVTDD--GNLKIS 255
Rat 256 WDSQTKAPFPLQYQVKYLENSTIVREAAE-----IVSDTSLLVDSVLPGSSYEVQVRSKRLDGSG 315
Rat 316 VWSDW---------------SLPQL----------------------------FTTQDVMYFPPK 337
Rat 338 ILTSV-GSNASFCCIYKNENQTISS--KQIVWWMNLAEKIPETQYNTVSDHISKVTFSNLKATRP 399
Rat 400 RGKFTYDA-VYCCNEQACHHRYAELYVIDVNINISCETDGYLTKMTCRWSPSTIQSLVGSTVQLR 463
Rat 464 YHRRSLYC--PDNPSI-------------RPTSELKNCVLQTDGFYECVFQPIFLLSGYTMWIRI 513
Rat 514 NHSLGSLDSPPTCVLPD-----------SVVK-PLPPSNVKAE-------ITINTGLLKVSWEKP 559
Rat 560 VFPENNLQFQI-RYGLNGKEI-----------QWKTHEVFDAKSKSASLPVSDLCAVYVVQVRCR 612
Rat 613 RLDGLGYWSNWSSPAYTLVMDVKVPMRGPEFW----RIMDGDITKKERNVTLLWKPLMKNDSLCS 673
Rat 674 VRRYVVKHRT--AHNGTWS-QDVGNQTNLTFL------WAESAHTVTVLAINSIGASLVNFNLTF 729
Rat 730 SWPMSKVNAVQSLSAYP--------LSSSCVILSWTLSPNDYSLL-----YLVIEWKNLNDDDGM 781
Rat 782 KWLRIPSNVNKYYIHDNFIPIEKYQFSLYPVFMEGVGKPKIING----FTKDDIAKQQNDAGLYV 842
Rat 843 IVPIIISSCVLLLGTLLISHQRMKKLFWDDVPNPKNCSWAQGLNFQKPETFEHLFTKHAESVIFG 907
Rat 908 PLLLEPEPVSEEISVDTAWKNKDEMVPAAMVSLLLT----------TPDSTRGSICISDQCNSAN 962
Rat 963 FSGAQSTQGTCEDECQSQPSVKY-----------------ATLVSNVKPVETDEEQGAIHSSVSQ 1010
Rat 1011 -CIARKHSPLRQSFSS-SSWEIEAQA------FFLLSDHPPNVISPQLSFSGL 1055 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Lepr | NP_036728.2 | ObR_Ig | 126..231 | CDD:408372 | 30/165 (18%) |
| FN3 | 236..328 | CDD:238020 | 21/141 (15%) | ||
| Lep_receptor_Ig | 327..418 | CDD:399379 | 21/94 (22%) | ||
| ObR_Ig | 429..531 | CDD:408372 | 25/127 (20%) | ||
| Leptin-binding. /evidence=ECO:0000250|UniProtKB:P48357 | 465..482 | 5/31 (16%) | |||
| FN3 | 535..625 | CDD:238020 | 28/108 (26%) | ||
| WSXWS motif | 620..624 | 1/3 (33%) | |||
| FN3 | 738..818 | CDD:214495 | 12/92 (13%) | ||
| Box 1 motif | 869..877 | 4/7 (57%) | |||
| Required for JAK2 activation. /evidence=ECO:0000250|UniProtKB:P48356 | 891..896 | 0/4 (0%) | |||
| Required for STAT3 phosphorylation. /evidence=ECO:0000250|UniProtKB:P48356 | 896..904 | 0/7 (0%) | |||
| sdk | NP_001284756.1 | Ig | 71..157 | CDD:299845 | 16/94 (17%) |
| I-set | 72..150 | CDD:254352 | 14/86 (16%) | ||
| Ig | 172..245 | CDD:299845 | 12/72 (17%) | ||
| IG_like | 280..356 | CDD:214653 | 13/75 (17%) | ||
| Ig | 280..343 | CDD:299845 | 10/62 (16%) | ||
| IG_like | 375..450 | CDD:214653 | 16/78 (21%) | ||
| Ig | 378..447 | CDD:143165 | 14/72 (19%) | ||
| Ig | 506..587 | CDD:299845 | 23/109 (21%) | ||
| IG_like | 506..587 | CDD:214653 | 23/109 (21%) | ||
| I-set | 592..682 | CDD:254352 | 21/107 (20%) | ||
| Ig | 595..682 | CDD:299845 | 20/104 (19%) | ||
| FN3 | 686..789 | CDD:238020 | 30/113 (27%) | ||
| FN3 | 798..893 | CDD:238020 | 23/111 (21%) | ||
| FN3 | 901..1005 | CDD:238020 | 22/139 (16%) | ||
| fn3 | 1011..1094 | CDD:278470 | 21/134 (16%) | ||
| FN3 | 1108..1202 | CDD:238020 | 12/67 (18%) | ||
| FN3 | 1210..1308 | CDD:238020 | |||
| fn3 | 1317..1402 | CDD:278470 | |||
| FN3 | 1415..1507 | CDD:238020 | |||
| FN3 | 1513..1608 | CDD:238020 | |||
| fn3 | 1617..1708 | CDD:278470 | |||
| FN3 | 1722..1823 | CDD:238020 | |||
| FN3 | 1828..1920 | CDD:238020 | |||
| FN3 | 1927..2016 | CDD:238020 | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.910 | |||||