DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nim1k and par-1

DIOPT Version :9

Sequence 1:	NP_780747.1	Gene:	Nim1k / 245269	MGIID:	2442399	Length:	436	Species:	Mus musculus
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	403	Identity:	145/403 - (35%)
Similarity:	219/403 - (54%)	Gaps:	57/403 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse    30 QTEGGKDSEEDQQRQLTPFE-KLTQDMCQDEKVVREITLGKRIGFYRIRGEIGSGNFSQVKLGIH 93
            :|...|.|...|.|...|.. :.|::               .||.|::...||.|||::|||..|
  Fly   223 RTSSAKGSPNMQMRSSAPMRWRATEE---------------HIGKYKLIKTIGKGNFAKVKLAKH 272

Mouse    94 SLTKEKVAIKILDKTKLDQKTQRLLSREISSMEKLHHPNIVRLYEVVETLSKLHLVMEYAGGGEL 158
            ..|.::|||||:|||:|:..:.:.|.||:..|:.|.|||||:|::|:||...|:|:||||.|||:
  Fly   273 LPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEV 337

Mouse   159 FGKISTEGKLSEPESKLIFSQILSAVKHMHENQIIHRDLKAENVFYTSRTCVKVGDFGFSTVSKK 223
            |..:...|::.|.|:::.|.||:|||::.|:.:||||||||||:...|...:|:.|||||.....
  Fly   338 FDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTP 402

Mouse   224 GEMLNTFCGSPPYAAPELFRDQHYVGVYVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTY 288
            |..|:||||||||||||||:.:.|.|..||:|:|||:||.:|:|::||...|:.:|::.:|.|.|
  Fly   403 GSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKY 467

Mouse   289 TIPQHVSEPCHRLIRGVLQPTPTERYGINYIMSNEWMRGVPYPTPLEPF------QLDPKHLSET 347
            .||.::|..|..|:|..|...|.:|..:..||.::||........|:|:      ..|||.:...
  Fly   468 RIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLADPKRIEAL 532

Mouse   348 STLKEEENEVKSTLEHLGITDE-------------------------HIRNNQGRDARSSI---- 383
            ..:....:|::::|..:...|.                         .:||..|.||.::.
  Fly   533 VAMGYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNISGNDAGANAGSAS 597

Mouse   384 ------TGVYRII 390
                  .||:|.|
  Fly   598 VQSPTHRGVHRSI 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nim1k	NP_780747.1	STKc_NIM1	71..325	CDD:270977	119/253 (47%)
Nim1k	NP_780747.1	S_TKc	74..325	CDD:214567	117/250 (47%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	117/251 (47%)
		S_TKc	253..504	CDD:214567	117/250 (47%)
		UBA_MARK_Par1	525..563	CDD:270522	6/37 (16%)
		MARK1-3_C	839..936	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910