Protein Alignment Kcna1 and Shawl

DIOPT Version :9

• Sequence 1: NP_775118.1
• Gene: Kcna1 / 24520
• RGDID: 2949
• Length: 495
• Species: Rattus norvegicus
• Sequence 2: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Alignment Length: 550
• Identity: 167/550 - (30%)
• Similarity: 255/550 - (46%)
• Gaps: 149/550 - (27%)

  Rat    38 RVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRL 102
            |:::|:||:|:||...||.:.|.|.|....:.:..:||:.|||||||:...|..||.||:: |:|
  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRT-GKL 69

  Rat   103 RRPVNVPLDMFSEEIKFYELGEEAMEK--------FREDEGFIK-------EEERPLPEKE---- 148
            ..|.:|...:|.||::|:.|....:|.        .|:.:..:.       |.|:|..|:.
  Fly    70 HYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIARLF 134

  Rat   149 -------------YQR---QVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDD-- 195
                         :||   ::|.:|:.|.||..|:::|.:||..|.:|::.|||:|.|..:.|
  Fly   135 GFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVDLP 199

  Rat   196 --------------------------------------KDFTGTIHRIDNTTVIYTSNIFT---- 218
                                                  ....|...|:.|.| .|:|..||
  Fly   200 SGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYT-SYSSGNFTASGQ 263

  Rat   219 ---------------------------------------------------DPFFIVETLCIIWF 232
                                                               :.||.||.:|.:||
  Fly   264 ATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELVCNVWF 328

  Rat   233 SFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLV 297
            ..|:::|....|:...|.|:.:|.||..|.:.::    |::.::.|...|       :|....:|
  Fly   329 FIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY----TDVMQRMGEYTG-------LLEAFSIV 382

  Rat   298 RVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE--AEEAESHFSSIP 360
            |:.|:|||:|||.||:||..|.|||.:||.||:|||.:|::.|:|..|:||  .:..::.|.|||
  Fly   383 RIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQFKSIP 447

  Rat   361 DAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY-HRETEG--- 421
            ...|||:|:||||||||:.|.|..|..||:|||:|||||||||||||||||:.|| |.:...
  Fly   448 LGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQARSKLP 512

  Rat   422 EEQAQLLHVSSPNLASDSDLSRRSSSTISK 451
            :::.::|.|..|....:.....|..:...|
  Fly   513 KKRRRVLPVEQPRRKREPTAPHRGRTNAIK 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kcna1	NP_775118.1	Tetramerization domain. /evidence=ECO:0000305	1..128		35/89 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30
		BTB_POZ	37..163	CDD:365784	46/159 (29%)
		Ion_trans	166..418	CDD:395416	114/349 (33%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	310..323		7/12 (58%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	372..377		4/4 (100%)
		PDZ-binding. /evidence=ECO:0000305	493..495
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	35/92 (38%)
		BTB_2	7..97	CDD:280393	35/90 (39%)
		Ion_trans	307..506	CDD:278921	94/209 (45%)
		Ion_trans_2	<449..499	CDD:285168	36/49 (73%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810