DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kcna1 and Shab

DIOPT Version :9

Sequence 1:	NP_775118.1	Gene:	Kcna1 / 24520	RGDID:	2949	Length:	495	Species:	Rattus norvegicus
Sequence 2:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster

Alignment Length:	474	Identity:	170/474 - (35%)
Similarity:	260/474 - (54%)	Gaps:	72/474 - (15%)

- Green bases have known domain annotations that are detailed below.

  Rat    38 RVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRY---------FDPLRNEYFFDRNRPSFDAIL 93
            ||.||:.|:|.|...:||.:.|:|.||..::...:         :....|||||||:..||.:||
  Fly   308 RVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSIL 372

  Rat    94 YYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAME-----KFREDEGFIKEEERPLPEK------ 147
            .:|:: |:|.....:.:..||::::::.:.|..:|     |:.:.:..:.||.|...|.
  Fly   373 NFYRT-GKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLRQRDE 436

  Rat   148 ---------EYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTIH 203
                     |||:.:|.|.|.|.:|..|||||::|::.|::|.:...|.|||:|:
  Fly   437 EEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLPQLQ---------- 491

  Rat   204 RIDNTTVIYTSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFIT 268
            .|||.|......:     .:||.:||.||:.|.::||.|.|.|..|||..:|.||::||:|||::
  Fly   492 HIDNGTPQDNPQL-----AMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVS 551

  Rat   269 LGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFL 333
            |  .:.|...|...:......:::|.|::|:.||.||:|||.|||.||.||:.|.:|||||:.||
  Fly   552 L--FLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFL 614

  Rat   334 FIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVL 398
            .:||::|||..||||.:|.::.|.|||:.||||.::||||||||:||.|..||::|::|.|.|||
  Fly   615 AMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVL 679

  Rat   399 TIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTISKSEYMEIEEDMNN 463
            .||||:|:||:||..||..:...|:.                |.||.:...:|.|         .
  Fly   680 VIALPIPIIVNNFAEFYKNQMRREKA----------------LKRREALDRAKRE---------G 719

  Rat   464 SIAHYRQANIRTGNCTATD 482
            ||..:...|::.....:.|
  Fly   720 SIVSFHHINLKDAFAKSMD 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kcna1	NP_775118.1	Tetramerization domain. /evidence=ECO:0000305	1..128		30/98 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		BTB_POZ	37..163	CDD:365784	43/153 (28%)
		Ion_trans	166..418	CDD:395416	116/251 (46%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	310..323		7/12 (58%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	372..377		4/4 (100%)
		PDZ-binding. /evidence=ECO:0000305	493..495
Shab	NP_001189037.1	BTB	309..416	CDD:197585	31/107 (29%)
		BTB_2	309..408	CDD:280393	30/99 (30%)
		Ion_trans	501..700	CDD:278921	99/205 (48%)
		Ion_trans_2	613..696	CDD:285168	48/82 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810