Protein Alignment Hspa1a and Hsp70Ba

DIOPT Version :9

• Sequence 1: NP_114177.2
• Gene: Hspa1a / 24472
• RGDID: 1593284
• Length: 641
• Species: Rattus norvegicus
• Sequence 2: NP_731716.1
• Gene: Hsp70Ba / 44921
• FlyBaseID: FBgn0013277
• Length: 641
• Species: Drosophila melanogaster
• Alignment Length: 640
• Identity: 488/640 - (76%)
• Similarity: 556/640 - (86%)
• Gaps: 5/640 - (0%)

  Rat     6 AIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDA 70
            |||||||||||||||:|||||||||||||||||||||||||:||||||.||||||:||:||||||
  Fly     3 AIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFDA 67

  Rat    71 KRLIGRKFGDPVVQSDMKHWPFQVVNDGDKPKVQVNYKGENRSFYPEEISSMVLTKMKEIAEAYL 135
            |||||||:.||.:..|||||||:||:||.|||:.|.||||::.|.||||||||||||||.|||||
  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAYL 132

  Rat   136 GHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDL 200
            |..:|:|||||||||||||||||||||.|||||||||||||||||:|||||:..|||||||||||
  Fly   133 GESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDL 197

  Rat   201 GGGTFDVSILTIDDG-IFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLR 264
            |||||||||||||:| :|||::|||||||||||||||||:|..||||||:|||:..|.||:||||
  Fly   198 GGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALRRLR 262

  Rat   265 TACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKLDKA 329
            ||.|||||||||||:|::|||:||||.||||.::||||||||:||||.||:||||||.|||:||.
  Fly   263 TAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDKG 327

  Rat   330 QIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLL 394
            ||||:|||||||||||||.|||:||:|::||.|||||||||||||||||||.||:|..:||:||:
  Fly   328 QIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLV 392

  Rat   395 DVAPLSLGLETAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRF 459
            ||||||||:||||||||.||:||..||.|||:||:|||||||||.|||||||||||:|||.||.|
  Fly   393 DVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEGERAMTKDNNALGTF 457

  Rat   460 ELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAER 524
            :|||||||||||||||||||:||||||||:|.:.|||||..|||.|||||||:.||:|||.|||:
  Fly   458 DLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAEK 522

  Rat   525 YKAEDEVQRERVAAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDSNTLAEK 589
            |..|||..|:|:.::||||||.:|:|.:|| :...||:.||||..|||||.|.|.||||||.|||
  Fly   523 YADEDEKHRQRITSRNALESYVYNVKQSVE-QAPAGKLDEADKNSVLDKCNETIRWLDSNTTAEK 586

  Rat   590 EEFVHKREELERVCNPIISGLY-QGAGAPGAGGFGAQAPKGGSG--SGPTIEEVD 641
            |||.||.|||.|.|:||::.:: |||||.|..|.......||.|  ||||:||||
  Fly   587 EEFDHKMEELARHCSPIMTKMHQQGAGAAGGPGANCGQQAGGFGGYSGPTVEEVD 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hspa1a	NP_114177.2	PTZ00009	1..641	CDD:240227	486/638 (76%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..386		311/380 (82%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	308/375 (82%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	394..509		92/114 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	618..641		11/24 (46%)
Hsp70Ba	NP_731716.1	PTZ00009	2..641	CDD:240227	486/638 (76%)
		HSPA1-2_6-8-like_NBD	3..379	CDD:212675	308/375 (82%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74294
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	1	1.100	-	-	LDO	PTHR19375
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.020