DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hspa1a and Hsc70-2

DIOPT Version :9

Sequence 1:	NP_114177.2	Gene:	Hspa1a / 24472	RGDID:	1593284	Length:	641	Species:	Rattus norvegicus
Sequence 2:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster

Alignment Length:	646	Identity:	463/646 - (71%)
Similarity:	532/646 - (82%)	Gaps:	19/646 - (2%)

- Green bases have known domain annotations that are detailed below.

  Rat     1 MAKKTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQN 65
            |.|..|||||||||||||||:|:.||||||||||||||||||||.:|||||||.||||||:|.:|
  Fly     1 MGKIPAIGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKN 65

  Rat    66 TVFDAKRLIGRKFGDPVVQSDMKHWPFQVVNDGDKPKVQVNYKGENRSFYPEEISSMVLTKMKEI 130
            |||||||||||||.|..:|.|:|.|||:|:|:..|||::|.:|||.:.|.||||||||||||:||
  Fly    66 TVFDAKRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMREI 130

  Rat   131 AEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNV 195
            ||.|||..|.:||:||||||||||||||||||.|||||||||||||||||:|||||:..||||||
  Fly   131 AEVYLGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGERNV 195

  Rat   196 LIFDLGGGTFDVSILTIDDG-IFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRA 259
            |||||||||||||:|:||:| :||||||||||||||||||||||:||.||||||||.||..|.||
  Fly   196 LIFDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARA 260

  Rat   260 VRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDA 324
            :||||||||||||||||||:||||||:|.||||||:.|:|||||||..||||.|::|||:||.||
  Fly   261 LRRLRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSDA 325

  Rat   325 KLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQ 389
            |:||..|||:|||||||||||:||||||.|.|:.||.|||||||||||||||||||.|..|..:|
  Fly   326 KMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQ 390

  Rat   390 DLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNN 454
            ||||:||||||||:||||||||.|::||:.||.||.|.||||||||..|.|||||||||||:|||
  Fly   391 DLLLVDVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMTKDNN 455

  Rat   455 LLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMV 519
            |||.|.|:||||||||||||||.||::|:|||||.|.|.||||:.||||:||||||||.||:||:
  Fly   456 LLGTFNLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEIDRML 520

  Rat   520 QEAERYKAEDEVQRERVAAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDSN 584
            .|||:||.||:.|||||.:||.||:|.:..:.|| |:...|.:||.::.||.|||....||||.|
  Fly   521 SEAEKYKVEDDRQRERVQSKNNLEAYIYACRQAV-DDAPSGVLSETERSKVRDKCSSEASWLDKN 584

  Rat   585 TLAEKEEFVHKREELERVCNPIISGLYQGAGAPGAGGFGAQAPKG----GSGSGPTIEEVD 641
            :|||||||....:|.:|:|.||:|.::.|             .||    |.||.||:||||
  Fly   585 SLAEKEEFESHLKECQRICTPIMSKIHGG-------------KKGKSSMGKGSHPTVEEVD 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hspa1a	NP_114177.2	PTZ00009	1..641	CDD:240227	461/644 (72%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..386		302/384 (79%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	299/375 (80%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	394..509		87/114 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..641		9/26 (35%)
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	461/644 (72%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	299/375 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74294
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	1	1.100	-	-	O	PTHR19375
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.930