DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FRK and BCK1

DIOPT Version :9

Sequence 1:	NP_002022.1	Gene:	FRK / 2444	HGNCID:	3955	Length:	505	Species:	Homo sapiens
Sequence 2:	NP_012440.1	Gene:	BCK1 / 853350	SGDID:	S000003631	Length:	1478	Species:	Saccharomyces cerevisiae

Alignment Length:	275	Identity:	78/275 - (28%)
Similarity:	134/275 - (48%)	Gaps:	52/275 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   240 LGSGQFGEVWEGLWNNTT--PVAVKTLK-PGSMDPNDFL--------REAQIMKNLRHPKLIQLY 293
            :|.|.||.|:..| |.||  .:|||.:: |.....|:.:        .|...:|:|.|..::| |
Yeast  1181 IGKGSFGAVYLCL-NVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNIVQ-Y 1243

Human   294 AVCTLEDPIY-IITELMRHGSLQEYLQNDTGSKIHLTQQVD------MAAQVASGMAYLESRNYI 351
            .....::.|| :..|.:..||:        ||.|.:..:.|      :..||..|:|||.|:..:
Yeast  1244 LGFENKNNIYSLFLEYVAGGSV--------GSLIRMYGRFDEPLIKHLTTQVLKGLAYLHSKGIL 1300

Human   352 HRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIY-ESRHEIKLPVKWTAPEAIRSNK-FSIKS 414
            |||:.|.|:|:.:..|.|::|||::|    .::||| .|...::..|.|.|||.:.:.: :|.|.
Yeast  1301 HRDMKADNLLLDQDGICKISDFGISR----KSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKV 1361

Human   415 DVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCP-----------QQFYNIMLE 468
            |:||.|.::.|:.. ||.|:|.      ::::|..:::.:..:.|           |...|.:..
Yeast  1362 DIWSLGCIVLEMFA-GKRPWSN------LEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDA 1419

Human   469 CWNAEPKERPTFETL 483
            |:...|::|||...|
Yeast  1420 CFEINPEKRPTANEL 1434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FRK	NP_002022.1	SH3_Src_like	47..104	CDD:212779
		SH2_Src_Frk	112..207	CDD:199831
		PTKc_Frk_like	225..494	CDD:270653	78/275 (28%)
BCK1	NP_012440.1	STKc_Bck1_like	1173..1440	CDD:270799	78/275 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910