DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FRK and BEM1

DIOPT Version :9

Sequence 1:	NP_002022.1	Gene:	FRK / 2444	HGNCID:	3955	Length:	505	Species:	Homo sapiens
Sequence 2:	NP_009759.3	Gene:	BEM1 / 852499	SGDID:	S000000404	Length:	551	Species:	Saccharomyces cerevisiae

Alignment Length:	430	Identity:	88/430 - (20%)
Similarity:	158/430 - (36%)	Gaps:	108/430 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    31 NPGALCSPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSS-- 93
            |.|:|          |.:.|:|::|..|::|:...|:.|.:. ..|...||......|..|..
Yeast   154 NMGSL----------YAIVLYDFKAEKADELTTYVGENLFIC-AHHNCEWFIAKPIGRLGGPGLV 207

Human    94 --------QQLQGYIPSNYVAED-RSLQ---AEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESE 146
                    ....||...|.|.|| :|:.   .:.| ...|.|..|....|.|..:.....|.:.:
Yeast   208 PVGFVSIIDIATGYATGNDVIEDIKSVNLPTVQEW-KSNIARYKASNISLGSVEQQQQQSITKPQ 271

Human   147 SQKGEFSLSVLDG-----AVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKL-- 204
            ::    |..::||     |.|:.:.::  ||..:||                      :|.:|
Yeast   272 NK----SAKLVDGELLVKASVESFGLE--DEKYWFL----------------------VCCELSN 308

Human   205 GKP-CLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGS 268
            ||. .||......:||..:.:|.:..:...:    |...||        |:       |.:.|..
Yeast   309 GKTRQLKRYYQDFYDLQVQLLDAFPAEAGKL----RDAGGQ--------WS-------KRIMPYI 354

Human   269 MDP-----NDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHL 328
            ..|     |...::.:...|:....|:.|....:..:.::.:..::.:|..:|:.:::..:.|..
Yeast   355 PGPVPYVTNSITKKRKEDLNIYVADLVNLPDYISRSEMVHSLFVVLNNGFDREFERDENQNNIKT 419

Human   329 TQQVDMAA-QVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHE 392
            .|:.|.|. ..||..:...|.|   :|    |.|.||       |..|.:  |:.:..:..|:
Yeast   420 LQENDTATFATASQTSNFASTN---QD----NTLTGE-------DLKLNK--KLSDLSLSGSK-- 466

Human   393 IKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKM 432
             :.|.:.|:.......||..|.|:  |.::|....||.::
Yeast   467 -QAPAQSTSGLKTTKIKFYYKDDI--FALMLKGDTTYKEL 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FRK	NP_002022.1	SH3_Src_like	47..104	CDD:212779	14/66 (21%)
		SH2_Src_Frk	112..207	CDD:199831	19/104 (18%)
		PTKc_Frk_like	225..494	CDD:270653	41/214 (19%)
BEM1	NP_009759.3	SH3_Bem1p_1	76..127	CDD:212811
		SH3_Bem1p_2	159..214	CDD:212812	13/55 (24%)
		PX_Bem1p	284..400	CDD:132800	26/158 (16%)
		PB1	478..549	CDD:214770	8/28 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I3374
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000