DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FRK and frk

DIOPT Version :9

Sequence 1:	NP_002022.1	Gene:	FRK / 2444	HGNCID:	3955	Length:	505	Species:	Homo sapiens
Sequence 2:	XP_021324228.1	Gene:	frk / 567549	ZFINID:	ZDB-GENE-110411-7	Length:	512	Species:	Danio rerio

Alignment Length:	461	Identity:	298/461 - (64%)
Similarity:	361/461 - (78%)	Gaps:	7/461 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSL 111
            :|||:||.|||.:||||.|||||:.: |..|.|||::.:    .|.|...:||||:||||...||
Zfish    57 YVALYDYTARTDDDLSFNAGDKLEPI-TKGEDWWFSKAI----TGISANKKGYIPANYVAPVESL 116

Human   112 QAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFF 176
            .||||:|....||||||.|:..|||.|:||||..|||.||.||||.|...||||:|::||.||::
Zfish   117 DAEPWYFPETKRSDAEKMLISQENKKGAFLIRNCESQPGELSLSVRDDVKVKHYKIRKLDNGGYY 181

Human   177 LTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLG 241
            |:..|.|.||.|.|.||:|..|||||:|.:||.|...|....|||.|||||||:|:|::|||:||
Zfish   182 LSTARNFPTLRELVEHYSKHEDGLCVRLAEPCKKSVAPETHGLSYNTVDQWEIERSSVKLLKQLG 246

Human   242 SGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIIT 306
            :||||||:|||||:||||||||||||:|||.||||||||||.|||.||||||||||||:||||||
Zfish   247 AGQFGEVFEGLWNDTTPVAVKTLKPGNMDPKDFLREAQIMKKLRHSKLIQLYAVCTLEEPIYIIT 311

Human   307 ELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVA 371
            |||.:|||.||||||.|:.:.::.|:||.|||||||||||.:|||||||||||||||::|:.|||
Zfish   312 ELMSNGSLLEYLQNDRGATLRMSDQIDMGAQVASGMAYLELQNYIHRDLAARNVLVGDNNVCKVA 376

Human   372 DFGLARVFKVDNED-IYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYS 435
            ||||||||::|||| :||::...|.||||||||||..|||:|||||||||||||||:|:|:.||.
Zfish   377 DFGLARVFQMDNEDNVYEAKEGTKFPVKWTAPEAINENKFTIKSDVWSFGILLYEIVTFGQTPYP 441

Human   436 GMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETD-SSYSD 499
            .||..||:|.|.:.||:..|.||.:..|:|||:||...|.:|||||||:|||||:|:.| :||.|
Zfish   442 TMTNFQVVQQLPKGYRMSSPPNCHKCLYDIMLDCWKDVPADRPTFETLQWKLEDFFDMDITSYDD 506

Human   500 ANNFIR 505
            ||.|.:
Zfish   507 ANRFAK 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FRK	NP_002022.1	SH3_Src_like	47..104	CDD:212779	28/56 (50%)
		SH2_Src_Frk	112..207	CDD:199831	55/94 (59%)
		PTKc_Frk_like	225..494	CDD:270653	193/269 (72%)
frk	XP_021324228.1	SH3_Src_like	56..109	CDD:212779	28/56 (50%)
		SH2_Src_family	117..212	CDD:199827	55/94 (59%)
		PTKc_Frk_like	230..500	CDD:270653	193/269 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194344219
Domainoid	1	1.000	383	1.000	Domainoid score	I5042
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48065
Inparanoid	1	1.050	609	1.000	Inparanoid score	I5155
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG44834
OrthoDB	1	1.010	-	-		D195127at7742
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		oto43134
orthoMCL	1	0.900	-	-		OOG6_108172
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3556
SonicParanoid	1	1.000	-	-		X5849
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	18	18.340