Protein Alignment FRK and wnd

DIOPT Version :9

• Sequence 1: NP_002022.1
• Gene: FRK / 2444
• HGNCID: 3955
• Length: 505
• Species: Homo sapiens
• Sequence 2: NP_649137.3
• Gene: wnd / 40143
• FlyBaseID: FBgn0036896
• Length: 977
• Species: Drosophila melanogaster
• Alignment Length: 552
• Identity: 139/552 - (25%)
• Similarity: 213/552 - (38%)
• Gaps: 192/552 - (34%)

Human    12 LEPYLPCLSTEADKSTVIENPGALCSPQSQRHG---HY-----------------FVAL---FDY 53
            ::|:...||...|....     |....|.|.||   |:                 ...|   |.:
  Fly     1 MQPFSDSLSKSRDDLVT-----AASRQQQQLHGRRRHHGSSPNLSLDQTDNLRRSMACLQDEFGH 60

Human    54 QARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYV------AEDRSLQ 112
            ....|.||.|::.|    ||                  |..:||.:  :||.      ||:...|
  Fly    61 LGIAATDLPFKSSD----LD------------------SPPRLQHH--NNYAEITDSSAENTCQQ 101

Human   113 AEP------------------WFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDG 159
            ..|                  |.:|.:|   ..|.:|....|||   :.|.:||:.|
  Fly   102 RWPPHVGGAGAAFGHPDKPIGWMYGLLG---CMKPVLSFIGKTG---VIEVKSQRSE-------- 152

Human   160 AVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTV 224
                                                                             
  Fly   153 ----------------------------------------------------------------- 152

Human   225 DQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQI--MKNLRHP 287
             .|:|...||..|:.||||..|.|:.|...|.| ||||.:|.        |:|..|  ::.|.|.
  Fly   153 -DWQIPFESITELEWLGSGAQGAVFSGRLKNET-VAVKKVKE--------LKETDIKHLRKLDHE 207

Human   288 KLIQLYAVCTLEDPIY-IITELMRHGSLQEYLQNDTGSKIHL-TQQVDMAAQVASGMAYLESRNY 350
            .:|:...||| :.|:: ||.|...:|.||..|:.:   ::.| ::.|..:.|:|.||.||.|...
  Fly   208 NIIKFKGVCT-QSPVFCIIMEFCPYGPLQNILKEE---QVMLPSRLVSWSKQIALGMQYLHSHKI 268

Human   351 IHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSD 415
            |||||.:.|:|:..:.:.|::|||.:|.:   ||  ..::......|.|.|||.||:...|.|.|
  Fly   269 IHRDLKSPNILISTNEVVKISDFGTSREW---NE--ISTKMSFAGTVAWMAPEVIRNEPCSEKVD 328

Human   416 VWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQN-YRLPQPSNCPQQFYNIMLECWNAEPKERPT 479
            :||:|::|:|::|. ::||..:..:.:|..:..| .:|..||.||:.|..::..||.::|:.||:
  Fly   329 IWSYGVVLWEMLTC-EIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPS 392

Human   480 F------------ETLRWKLEDYFETDSSYSD 499
            |            |.||...:.||||..|:.:
  Fly   393 FRQILSHLDIAGPELLRKTEKQYFETQKSWKE 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FRK	NP_002022.1	SH3_Src_like	47..104	CDD:212779	12/59 (20%)
		SH2_Src_Frk	112..207	CDD:199831	14/112 (13%)
		PTKc_Frk_like	225..494	CDD:270653	97/285 (34%)
wnd	NP_649137.3	STYKc	161..400	CDD:214568	88/257 (34%)
		STKc_MAP3K12_13	167..403	CDD:270961	86/254 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910