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Protein Alignment Grin2a and Nmdar1

DIOPT Version :9

Sequence 1:	NP_036705.3	Gene:	Grin2a / 24409	RGDID:	2737	Length:	1464	Species:	Rattus norvegicus
Sequence 2:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster

Alignment Length:	1137	Identity:	300/1137 - (26%)
Similarity:	495/1137 - (43%)	Gaps:	248/1137 - (21%)

- Green bases have known domain annotations that are detailed below.

  Rat     9 LLVLPALLVWRDPAQNAAAEKGPPALNIAVLLGHS----HDVTERELRNL---WGPEQAT----G 62
            |||.|.     |.||...|...|...||..:|.:|    |..|..:..|.   :.|.:.|    .
  Fly    19 LLVAPI-----DAAQRHTASDNPSTYNIGGVLSNSDSEEHFSTTIKHLNFDQQYVPRKVTYYDKT 78

  Rat    63 LPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVF-----GDDTDQEAVAQMLDFISSQTFI 122
            :.:|.|.:..:.|          |||.:...|::.:|.     ..|....||:....|.|    |
  Fly    79 IRMDKNPIKTVFN----------VCDKLIENRVYAVVVSHEQTSGDLSPAAVSYTSGFYS----I 129

  Rat   123 PILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYRDFISFI 187
            |::|| .......:||:...:|.:.......||.|.|:::..:.:....::.:.....|..:...
  Fly   130 PVIGI-SSRDAAFSDKNIHVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRF 193

  Rat   188 KTTVDNSFVGWDMQNVITLDTSFE---DAKTQ--VQLKKIHSSVILLYCSKDEAVLILSEARSLG 247
            :||....:...|::..:.|...||   ::.|:  :.:|...|.|.|:|.|.::|.:|..:|....
  Fly   194 QTTSQTYYDDVDVRATVELIVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYN 258

  Rat   248 LTGYDFFWIV--PSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGLGILTTAASSMLEKF 310
            :||....|||  .:|.|.||       |.|::.:..:. .:|.:..:||.:.:|.:|...|:..
  Fly   259 MTGEGHVWIVTEQALFSNNT-------PDGVLGLQLEH-AHSDKGHIRDSVYVLASAIKEMISN- 314

  Rat   311 SYIPEAKASCYGQAEKPETPLHTLHQFMV--NVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWE 373
            ..|.||...|...|...|:. ..|.|::.  |:|.:...::|.:.|.:::....||.:.:.::..
  Fly   315 ETIAEAPKDCGDSAVNWESG-KRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKH 378

  Rat   374 KVGKWENQTLSLR--------HAVWP---RYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTE 427
            .|||:...::..:        ..:||   |.|......|  .||.::|:||.|||.|..:.....
  Fly   379 VVGKFSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIP--THLRLLTIEEKPFVYVRRMGDDEF 441

  Rat   428 TCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKV--N 490
            .|..:..||..|...:.:.||     .||:|:|||:|.:||:.:.|||||.|..:|:.|..:  |
  Fly   442 RCEPDERPCPLFNNSDATANE-----FCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRN 501

  Rat   491 NV--------WNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVM---VSRSNGTV 544
            |.        |.|:|||:|.:||.|.|..||||.||:|.::||.||...||:::   .|||:..|
  Fly   502 NTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSSTLV 566

  Rat   545 SPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPS-----FTIGKA 604
            |   ||:|||.::|:::.|.:.:| |:.:::.:.|||.|      :.|..|..|     ..:..|
  Fly   567 S---FLQPFSNTLWILVMVSVHVV-ALVLYLLDRFSPFG------RFKLSHSDSNEEKALNLSSA 621

  Rat   605 IWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKK 669
            :|..||::.|:.:....|:..:::::..|||.||:|.:||||||||||::.|....:::|::|.:
  Fly   622 VWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDAR 686

  Rat   670 FQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQY--MTRFNQRGVEDALVSLKTGKLDAFIYDA 732
            .:...:   .....||...|.:...|......:.|  |...|....|.|:..:|.|||.|||:|:
  Fly   687 LRNTME---NLTCATVKGSSVDMYFRRQVELSNMYRTMEANNYATAEQAIQDVKKGKLMAFIWDS 748

  Rat   733 AVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWL- 796
            :.|.|:|.:|  |:|||  :|.:|..:||||.|||||||...:.||:|:|...|.||:|:..|:
  Fly   749 SRLEYEASKD--CELVT--AGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIF 809

  Rat   797 TGICHNEKN----EVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFCFTGVCSDRP 857
            .|  |.::|    |...:.|.:.||||||.::...:|                    .||
  Fly   810 HG--HVQQNCELFEKTPNTLGLKNMAGVFILVGVGIA--------------------GGV----- 847

  Rat   858 GLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRSAKNISNMSNMNSSRMDSPKRAT 922
            ||:      |...|:..|..:|:|                                |:|..:.|.
  Fly   848 GLI------IIEVIYKKHQVKKQK--------------------------------RLDIARHAA 874

  Rat   923 DFIQRGSLIVDMVSDKGNLIYSDNRSFQGKDSIFGDNMNELQTFVANRHKDNLSNYVFQGQHPLT 987
            | ..||::                                      .:.|...::...|.|:.:.
  Fly   875 D-KWRGTI--------------------------------------EKRKTIRASLAMQRQYNVG 900

  Rat   988 LNESN-PNTVEVAVSTESKGNSR------PRQLW---KKSMESLRQDSLNQNPVSQRDEKTAENR 1042
            ||.:: |.|:.:||  :.:...|      |.:.|   ...:..:|:.....|| .|..:..|.|:
  Fly   901 LNSTHAPGTISLAV--DKRRYPRLGQRLGPERAWPGDAADVLRIRRPYELGNP-GQSPKVMAANQ 962

  Rat  1043 -------------THSLKSPRYLP---EEVAH 1058
                         ..|:..|||.|   .:|:|
  Fly   963 PGMPMPMLGKTRPQQSVLPPRYSPGYTSDVSH 994

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.