DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grik5 and GluRIIC

DIOPT Version :9

Sequence 1:	XP_006228444.1	Gene:	Grik5 / 24407	RGDID:	2735	Length:	980	Species:	Rattus norvegicus
Sequence 2:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	898	Identity:	257/898 - (28%)
Similarity:	426/898 - (47%)	Gaps:	105/898 - (11%)

- Green bases have known domain annotations that are detailed below.

  Rat    73 DSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIK--VGPE----ETPRLQYL 131
            |......:..|.::..||.::.||||..|| ..|:.:|....||||:  :..|    |.|..|
  Fly    71 DGSVTMQEHACDLIDNGVAAIFGPSSKAAS-DIVALVCNSTGIPHIEFDISDEGIQAEKPNHQ-- 132

  Rat   132 RFASVSLYPSNEDVSLAVSRILKSFNYPSASLI--CAKAECLLRLEELVRGFLISKETLSVRMLD 194
              .:::|||:...:|.|.:.|:::|.:...:::  ...|....||::|::...:..:.:.||...
  Fly   133 --MTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKFH 195

  Rat   195 DSRDPTPLLKEIRDDKVSTIIIDANASISHLVLRKASELGMTSAFYKYILTTMDFPILHLDGIVE 259
            ...|...:.|.||.::  .:::|...::...:|..::|.|:|..:....||.::....||:.:..
  Fly   196 KDDDFRVMWKSIRGER--RVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAA 258

  Rat   260 DSS----NILGFSMF-NTSHPFYPEFVRSLNMSW---REN-CEASTYPGPALSAALMFDAVHVVV 315
            |:.    ||....:. |...|.|     ||...:   |:| ...|:.|...|...|:.||:.:..
  Fly   259 DNETFAVNITAARLLVNPDPPPY-----SLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFA 318

  Rat   316 SAVRELNRS----QEIGVKPLAC----TSANIWPHGTSLMNYLRMVEYDGL------TGRVEFNS 366
            .:.|  |.|    ..:.|..:.|    :....|..|..|...::..  .|:      |..::|:.
  Fly   319 QSWR--NASFFYPDRMVVPRITCDFAASGGRTWAMGRYLARLMKGT--SGVNNTNFRTSILQFDE 379

  Rat   367 KGQRTNYTLRILEK-SRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLV--VTTILENPY- 427
            .|||..:.:.:.:. ...|   |.:|.....:    |.|::::.   |.|.::  |.|.:..||
  Fly   380 DGQRITFNIEVYDPLDGIG---IAIWDPRGQI----TQLNVDVK---AQKKMIYRVATRIGPPYF 434

  Rat   428 ----VMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYG-APEPNGSWTGMVGE 487
                ..|..|   |:||..::|:.||::..:|..:.|.|....|.|..|| ..:....|.|::||
  Fly   435 SYNETARELN---LTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGE 496

  Rat   488 LINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISIL-YR-VHMGRKPGYFSFLDPFSPAVWLF 550
            :||.. |.:.:...|||..|:..:||:.|||.||:||| |: .|:.:.  ..::|.||...||::
  Fly   497 IINND-AHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKT--LDAYLAPFGGEVWIW 558

  Rat   551 MLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRA 615
            :|::...::.:..:.||:|..:|.|||||.| .|.:||||:.:.|:.|..|...|..|.:|:||:
  Fly   559 ILISVFVMTFLKTIVARISKMDWENPHPCNR-DPEVLENQWRIHNTGWLTVASIMTAGCDILPRS 622

  Rat   616 LSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQ 680
            ...|.....||.|.:||.:|||||||||||..:||..:.:..||:.|..:::|||:.|||.....
  Fly   623 PQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLA 687

  Rat   681 NSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSR--YAFLLESTMNEYHRRLNCNLTQIGGL 743
            :|....|:..:|.|.:..||.:.|...||:.||..:|  |.||:|:|..||||..||:|..:|..
  Fly   688 DSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDLRSVGEK 752

  Rat   744 LDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWE--GGRCPKEEDHRA-KGLGMENI 805
            ...|.|.|.:|.|:.:|..:::|||:|.|...|..||:|||:  ...|.:|.|..| ..:..|.:
  Fly   753 FGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMTFEEL 817

  Rat   806 GGIFVVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAV---------------- 854
            .|||..|..|::||..:.:.||:...::.|..|.::......:|:|..:
  Fly   818 RGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPIS 882

  Rat   855 SCRKTSR----SRRRRRPGGPSRALL--SLRAVREMRLSNGKLYSAGAGGDAG 901
            |.|.|.|    ....|.|....|.::  |...:|||...:|   |:....:||
  Fly   883 SVRTTPRRSLDKSLDRTPKSSRRVVIGRSSEEMREMAQGSG---SSSGSNNAG 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik5	XP_006228444.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	79/359 (22%)
Grik5	XP_006228444.1	Periplasmic_Binding_Protein_Type_2	414..785	CDD:389745	141/382 (37%)
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	79/351 (23%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	20/92 (22%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	140/377 (37%)
		Lig_chan	554..828	CDD:278489	105/274 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349755
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.860