Protein Alignment Grik5 and Ir8a

DIOPT Version :9

• Sequence 1: XP_006228444.1
• Gene: Grik5 / 24407
• RGDID: 2735
• Length: 980
• Species: Rattus norvegicus
• Sequence 2: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Alignment Length: 1118
• Identity: 252/1118 - (22%)
• Similarity: 413/1118 - (36%)
• Gaps: 344/1118 - (30%)

  Rat     5 LLLLLIVAFANPS-----------------------CQVLSSLRMAAILDDQTVCGRGERLALAL 46
            |:|||.:.||...                       .:.|.:||:...:||.|         |.|
  Fly     6 LVLLLALRFAGSEVLKITFWIEPVQRAEFDTDIAMVLKELDALRLDVKVDDTT---------LTL 61

  Rat    47 AREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICG 111
            .|.:               |..::||         .|:||            |...||.|
  Fly    62 TRSE---------------DGLDMQR---------FCEIL------------STVGASAV----- 85

  Rat   112 EKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEE 176
                                             :.|..|...:.:|     |:.:.....:|||.
  Fly    86 ---------------------------------IDLTYSHWEEGYN-----LVRSLGIGYVRLER 112

  Rat   177 LVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHL-----------VLRKA 230
            ::|.||        .|..|      .:::.|.:.|:.:.::|..::..:           ::..|
  Fly   113 IMRPFL--------DMFGD------FMRQKRANNVAMVFMNARDAVEAMQQMLVGYPFRTLIMDA 163

  Rat   231 SELGMTSAFYKYILTTMDFP--------ILHLDGIVEDSSNILGFSMFNTSHPFYPEFV----RS 283
            |:......|.:.|.:....|        ...::||.|   .:....:|  ..|....||    |.
  Fly   164 SQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFE---KVQKADLF--QRPLEWHFVFLDTRD 223

  Rat   284 LNMSWRENCEAST------------YPGPALSAALMFDAVH-VVVSAVREL-NRSQEIGVKPLA- 333
            ....:|...|..|            .|.|.|.....|.... ::::.:|.| |.:|.....|||
  Fly   224 RVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGYPLAI 288

  Rat   334 -------CTSANIW-PHGTSLMNYLRMVEYDGLTG--------RVEFNSKGQRTNYTLRI----L 378
                   .:|:.:. |......|:|.||.:.....        :.:|.|......:.:.|    .
  Fly   289 YQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNISAGYY 353

  Rat   379 EKSRQGHREIGVWYSNRTLAMNATTLDINLSQTL--ANKTLVVTTILENP--YVMRRPNFQAL-- 437
            ....:...::..|.|...:.:        |::|:  |.:...:.|....|  |:.|......|
  Fly   354 SSEHEAKTDLAAWSSVGEMRL--------LNETISPARRFFRIGTAESIPWSYLRREEGTGELIR 410

  Rat   438 --SGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRQKADLAVAA 500
              ||...:||:|:|.:..|::.|.|.:.:...|.|..|.....|.|.|:||:|: |.:.|.|:||
  Fly   411 DRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWDGVVGDLV-RGETDFAIAA 474

  Rat   501 FTITAEREKVIDFSKPFM-TLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFL 564
            ..:.:|||:||||..|:. ..||||..|..: |:...|.|:......|||.::.|.:..:.:::.
  Fly   475 LKMYSEREEVIDFLPPYYEQTGISIAIRKPV-RRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWF 538

  Rat   565 AARLSPYEWYN-----PHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGV 624
            ..:.|||...|     |:.|         .::||..|.||.:..|..||....|:|:|.|.:...
  Fly   539 MDKYSPYSSRNNRQAYPYAC---------REFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAA 594

  Rat   625 WWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRY--QTY 687
            :|.|.:::::::||||||||||:||:.||:|.:.||.|:.|.|..:....|..:|.|.::  .|.
  Fly   595 YWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTL 659

  Rat   688 QRMWNYM-----------------------------QSKQPSVFVKSTEEGIARV---LNSRYAF 720
            .|||..:                             .|.||   |...:||.|.|   .|:.|||
  Fly   660 YRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQP---VADAKEGFANVDAHENADYAF 721

  Rat   721 LLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWE 785
            :.:|...:|....|||||::|.:...:.|.:.:..||...||::.|||:||::...|.||.|:|.
  Fly   722 IHDSAEIKYEITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWN 786

  Rat   786 GG---RCPKEEDHRAKGLGMENIGGIFVVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEML 847
            ..   .||..||.  :|:.:|::||:|:..:.||::|:....||.::..::          |..|
  Fly   787 QSNLPNCPLSEDQ--EGITLESLGGVFIATLFGLVLAMMTLGMEVLYYKKK----------QNAL 839

  Rat   848 QELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGAHGGPQRLLDD 912
            :                          :..:|.|.:         |:|:||::..
  Fly   840 E--------------------------ITQVRPVND---------SSGSGGNSST---------- 859

  Rat   913 PGPPGGPRPQAPTPCTHVRVCQECRRIQALRASGAGA----PP-------RGLGTPAEAT---SP 963
             .||           |.....::...|..|.|....|    ||       ||...||..|   ..
  Fly   860 -APP-----------TATSTTKQAWHIPVLEAEEKPAKVSPPPSFETATFRGKKLPARITLGDGK 912

  Rat   964 PRPRPGPTGPREL 976
            .:||.|....|.|
  Fly   913 FKPRHGLYARRNL 925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grik5	XP_006228444.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	71/435 (16%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:389745	129/416 (31%)
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	129/416 (31%)
		Lig_chan	520..818	CDD:278489	95/311 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810