DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grik4 and Nmdar1

DIOPT Version :9

Sequence 1:	NP_036704.1	Gene:	Grik4 / 24406	RGDID:	2734	Length:	956	Species:	Rattus norvegicus
Sequence 2:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster

Alignment Length:	910	Identity:	229/910 - (25%)
Similarity:	383/910 - (42%)	Gaps:	198/910 - (21%)

- Green bases have known domain annotations that are detailed below.

  Rat    92 VAVLGPSSSPASSSIISNICGEKEVPHFKVAPEEFVRF-----QLQRFT---TLNLHPSNTDISV 148
            :.|:|.||..|:.| ..||    .|...:..|..:.:.     .|..|.   .:.:|.|:||
  Fly   129 IPVIGISSRDAAFS-DKNI----HVSFLRTVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTD--- 185

  Rat   149 AVAGILNFFNCTTACL-----ICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDPTPLLKEIR 208
             ...||..|..|:...     :.|..|.::..|..|..|                  |..|.:::
  Fly   186 -GRAILGRFQTTSQTYYDDVDVRATVELIVEFEPKLESF------------------TEHLIDMK 231

  Rat   209 DDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLE-FSLQRMDSLVDDRVNILGFSIFN 272
            ..::...:::|:...:..|...|.|..|....:.:|.|... ||....|       .:||..:
  Fly   232 TAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALFSNNTPD-------GVLGLQL-- 287

  Rat   273 QSHAFFQEFSQSLNQSWQENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCG- 336
             .||             ..:..|:.            |:||.:.:|::|:..::.|...|..||
  Fly   288 -EHA-------------HSDKGHIR------------DSVYVLASAIKEMISNETIAEAPKDCGD 326

  Rat   337 SAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMD 401
            ||..|:.|..|..||:...:.|.||.:.|:..|.|......::     ..|:..:.||....|.|
  Fly   327 SAVNWESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVI-----NIREQQKKHVVGKFSYD 386

  Rat   402 S-----RLYASNISDS---------------LFNTTLVVTTILENPYLMLKG------------- 433
            |     |:   .|:||               :..|.|.:.||.|.|::.::.
  Fly   387 SMRAKMRM---RINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEPDER 448

  Rat   434 -----NHQDMEGND-RYEGFCVDMLKELAEILRFNYKIRLVGDGVYG---VPEANGT------WT 483
                 |:.|...|: ...|:|:|:|.||::.:.|.|.:.|..||.:|   :....|.      ||
  Fly   449 PCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWT 513

  Rat   484 GMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRRPGYFSFLDPFSPGVW 548
            |::|||:..:||:.||.|||..||.:.|:|||||...||:||.: ...|.....|||.|||..:|
  Fly   514 GLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEK-KPSRSSTLVSFLQPFSNTLW 577

  Rat   549 LFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQ------YSLGNSLWFPVGGFMQQ 607
            :.::::...|:.||:|:.|.:|:          ||..|..:.      .:|.:::||..|..:..
  Fly   578 ILVMVSVHVVALVLYLLDRFSPF----------GRFKLSHSDSNEEKALNLSSAVWFAWGVLLNS 632

  Rat   608 G-STIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESVDDLADQTAIE---YG 668
            | ....||:.|.|.:..||..|.:||::||||||||||.::|.:..:..::|...:..:|   ..
  Fly   633 GIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCA 697

  Rat   669 TIHGGSSMTFFQ-----NSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAFLLESTMNE 728
            |:.|.|...:|:     ::.|:|.:.. ||..::|.   ::..::|      ...||:.:|:..|
  Fly   698 TVKGSSVDMYFRRQVELSNMYRTMEAN-NYATAEQA---IQDVKKG------KLMAFIWDSSRLE 752

  Rat   729 YYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGG------ 787
            |...::|.|...|.|....|||||:..||.:.|...||||:..|:..:|.|.::|...|
  Fly   753 YEASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNC 817

  Rat   788 ----KCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRH--SEASEVSVCQEMM 846
                |.|..       ||::|:.|:|:::..|:...:.:.::|.::. :|  .:...:.:.:...
  Fly   818 ELFEKTPNT-------LGLKNMAGVFILVGVGIAGGVGLIIIEVIYK-KHQVKKQKRLDIARHAA 874

  Rat   847 TELRSIILCQDNIHPRRRRSGGLPPQPPV-LEERRPRGTATLSNGKLCGAGEPDQLAQRLAQEAA 910
            .:.|..|..:..|    |.|..:..|..| |......||.:|:..|    ....:|.|||..|.|
  Fly   875 DKWRGTIEKRKTI----RASLAMQRQYNVGLNSTHAPGTISLAVDK----RRYPRLGQRLGPERA 931

Rat 911 910
Fly 932 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grik4	NP_036704.1	Periplasmic_Binding_Protein_type1	24..402	CDD:415822	68/324 (21%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	126/412 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	74/345 (21%)
		ANF_receptor	58..371	CDD:279440	64/308 (21%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	127/421 (30%)
		HisJ	451..>558	CDD:223904	41/107 (38%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	48/145 (33%)
		Lig_chan	575..838	CDD:278489	80/289 (28%)
		CaM_bdg_C0	854..882	CDD:287524	2/28 (7%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910