DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gnb1 and Gbeta5

DIOPT Version :9

Sequence 1:	NP_112249.2	Gene:	Gnb1 / 24400	RGDID:	2718	Length:	340	Species:	Rattus norvegicus
Sequence 2:	NP_572452.1	Gene:	Gbeta5 / 31744	FlyBaseID:	FBgn0030011	Length:	358	Species:	Drosophila melanogaster

Alignment Length:	340	Identity:	164/340 - (48%)
Similarity:	244/340 - (71%)	Gaps:	3/340 - (0%)

- Green bases have known domain annotations that are detailed below.

  Rat     3 ELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDS 67
            ::..|.:|||.||.::.:.|:...|..||.|...::.:..:.::.|:.|:||.||:....|..|.
  Fly    18 KMASLVREAENLKTKLEEERQKLNDVNLSNIAERLEQIAYVNIKPRKVLKGHQAKVLCTDWSPDK 82

  Rat    68 RLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGN 132
            |.::|:||||:|||||::||||.||:.:.::|:|.||||||||:||||||||..::|.:.:.|..
  Fly    83 RHIISSSQDGRLIIWDAFTTNKEHAVTMPTTWIMACAYAPSGNFVACGGLDNKVTVYPITSDEEM 147

  Rat   133 VRVSRELAGHTGYLSCCRFLD-DNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDT 196
            ....|.:..||.|:|||.:.: |.||:|.|||:||||||:|:||...:|.||:||||::.|||:.
  Fly   148 AAKKRTVGTHTSYMSCCIYPNSDQQILTGSGDSTCALWDVESGQLLQSFHGHSGDVMAIDLAPNE 212

  Rat   197 --RLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQ 259
              ..||||:||..|.:||:|.|...|:|.||:||:|::.|.|.|:|.||||||::|||:|:|||:
  Fly   213 TGNTFVSGSCDRMAFIWDMRSGHVVQSFEGHQSDVNSVKFHPCGDAIATGSDDSSCRLYDMRADR 277

  Rat   260 ELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDG 324
            |:..::.::||.|:.||.||.|||||.|||:|:..|:||.||::|..:|.||:|:|||:.|:.||
  Fly   278 EVAVFAKESIIFGVNSVDFSVSGRLLFAGYNDYTVNLWDTLKSERVCLLYGHENKVSCVQVSPDG 342

  Rat   325 MAVATGSWDSFLKIW 339
            .|::|||||..:::|
  Fly   343 TALSTGSWDYTIRVW 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gnb1	NP_112249.2	WD40	48..340	CDD:238121	153/295 (52%)
		WD 1	53..83		15/29 (52%)
		WD40 repeat	58..95	CDD:293791	19/36 (53%)
		WD 2	95..125		18/29 (62%)
		WD40 repeat	101..141	CDD:293791	20/39 (51%)
		WD 3	141..170		17/29 (59%)
		WD40 repeat	146..181	CDD:293791	19/35 (54%)
		WD 4	182..212		16/31 (52%)
		WD40 repeat	188..223	CDD:293791	16/36 (44%)
		WD 5	224..254		18/29 (62%)
		WD40 repeat	229..265	CDD:293791	19/35 (54%)
		WD 6	268..298		17/29 (59%)
		WD40 repeat	273..309	CDD:293791	19/35 (54%)
		WD 7	310..340		16/30 (53%)
		WD40 repeat	315..339	CDD:293791	12/23 (52%)
Gbeta5	NP_572452.1	WD40	62..358	CDD:238121	153/296 (52%)
		WD40 repeat	73..110	CDD:293791	19/36 (53%)
		WD40 repeat	116..156	CDD:293791	20/39 (51%)
		WD40 repeat	161..197	CDD:293791	19/35 (54%)
		WD40 repeat	204..241	CDD:293791	16/36 (44%)
		WD40 repeat	247..283	CDD:293791	19/35 (54%)
		WD40 repeat	291..327	CDD:293791	19/35 (54%)
		WD40 repeat	333..357	CDD:293791	12/23 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D313727at33208
OrthoFinder	1	1.000	-	-		FOG0000271
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X182
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820