DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glra2 and GluClalpha

DIOPT Version :9

Sequence 1:	NP_036700.1	Gene:	Glra2 / 24397	RGDID:	2705	Length:	452	Species:	Rattus norvegicus
Sequence 2:	NP_001287408.1	Gene:	GluClalpha / 42350	FlyBaseID:	FBgn0024963	Length:	463	Species:	Drosophila melanogaster

Alignment Length:	434	Identity:	190/434 - (43%)
Similarity:	257/434 - (59%)	Gaps:	41/434 - (9%)

- Green bases have known domain annotations that are detailed below.

  Rat    48 LDKLMGRTSGYDARIRPN----FKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLA 108
            ||:::| ...|||||||:    ..||.| |..|||:.|...:.:.||:|.|.:..|:||.|.||.
  Fly    37 LDQILG-AGKYDARIRPSGINGTDGPAV-VRVNIFVRSISKIDDVTMEYSVQLTFREQWTDERLK 99

  Rat   109 YSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCP 173
            :.:.......|..:..:.:|.|||||:|||..:||::...|..:||..||.||||||::|||:||
  Fly   100 FDDIQGRLKYLTLTEANRVWMPDLFFSNEKEGHFHNIIMPNVYIRIFPNGSVLYSIRISLTLACP 164

  Rat   174 MDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKEL-GYCTKHYN 237
            |:||.:|:|.|.|::::.|:|:|.|||:|.|....||||.:.|.||:|.|  ||.| .||....|
  Fly   165 MNLKLYPLDRQICSLRMASYGWTTNDLVFLWKEGDPVQVVKNLHLPRFTL--EKFLTDYCNSKTN 227

  Rat   238 TGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSS 302
            ||:::|::|....:|:..|||||:|||..::||:||||||::..|.||||:||:||:|||.||:|
  Fly   228 TGEYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDQGAVPARVSLGVTTLLTMATQTS 292

  Rat   303 GSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSR-------QHKEFLRLRRRQKRQNK 360
            |..||||.|||.||||:|..|||.|||.||||:|.||:.||       .|||.::.:||...|..
  Fly   293 GINASLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYASRSGSNKANMHKENMKKKRRDLEQAS 357

  Rat   361 EE------DVTRESRFNF-SGYGMGHCLQVKDGTAVKATPANPLP-----------QPPKDADAI 407
            .:      |....:.|.. |.:..|...|    ..:...|.:||.           |.||..:..
  Fly   358 LDAASDLLDTDSNATFAMASQFARGGGQQ----KPLVRHPGDPLALEKRLQCEVHMQAPKRPNCC 418

  Rat   408 K---KKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHED 448
            |   .||..|:||||.|||..|||.|.:||:.||.||.....||
  Fly   419 KTWLSKFPTRSKRIDVISRITFPLVFALFNLVYWSTYLFREEED 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glra2	NP_036700.1	LIC	46..441	CDD:273305	186/425 (44%)
Glra2	NP_036700.1	Strychnine-binding. /evidence=ECO:0000250\|UniProtKB:O93430	236..241		3/4 (75%)
GluClalpha	NP_001287408.1	LIC	3..455	CDD:273305	186/425 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3542
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	341	1.000	Inparanoid score	I2275
OMA	1	1.010	-	-		QHG45222
OrthoDB	1	1.010	-	-		D276914at33208
OrthoFinder	1	1.000	-	-		FOG0000759
OrthoInspector	1	1.000	-	-		otm46272
orthoMCL	1	0.900	-	-		OOG6_101785
Panther	1	1.100	-	-	LDO	PTHR18945
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X271
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.980