DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kirrel2 and DIP-delta

DIOPT Version :9

Sequence 1:	NP_766486.1	Gene:	Kirrel2 / 243911	MGIID:	2442334	Length:	700	Species:	Mus musculus
Sequence 2:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	346	Identity:	81/346 - (23%)
Similarity:	128/346 - (36%)	Gaps:	78/346 - (22%)

- Green bases have known domain annotations that are detailed below.

Mouse    21 PHFLQQPEDMVVLLGEEARLPCA---LGAYRGLVQW--TKDGLALGGERD----LPGWS-----R 71
            |.|.|...::.|.:|.:|.|||.   ||.|:  |.|  ....:.|...|.    :|.:|     .
  Fly    44 PRFAQPIPNVTVAVGRDANLPCVVEHLGGYK--VAWIHIDRQMILTIHRHVISRIPRYSITYTDN 106

Mouse    72 YWISGNSASGQHDLHIKPVELEDEASYECQASQAGLRSRPAQLHVMVPPEAPQVLGGP-SVSLVA 135
            .|:          ||:.....:|...|.||.:...:.|:...|.|:|||....:...| ||::..
  Fly   107 TWL----------LHVNQAHQDDRGYYMCQVNTNPMISQVGYLQVVVPPNILDIESTPSSVAVRE 161

Mouse   136 GVPGNLTCRSRGDSRPAPELLWFRDGIRLDGSSFHQTTLKDKATGTVENTLFLTPSSHDDGATLI 200
            ....|:|||:  |..|||:::|.|:    ||... ....|.|......:.|.||..|.::....:
  Fly   162 NQNINMTCRA--DGFPAPKIIWRRE----DGEEI-AVEKKKKVLVYDADVLPLTKVSRNEMGAYL 219

Mouse   201 CRARSQALPTGRDTAVTLSLQYPPMVTLSAEPQTVQEGEKVTFLCQATAQPPVTGYRWAKGGSPV 265
            |.| :..:|......:.|.:::.||:.:..:......|..||..|...|.|....| |......|
  Fly   220 CIA-TNGVPPSVSKRIILDVEFSPMIWVPNQLVGAPSGTDVTIDCHTEAHPKAIIY-WVYNSVMV 282

Mouse   266 LGARGPRLEVVADATFLTEPVSCEVSNAVGSANRSTALEVLYGPILQAKPKSVSVDVGKDASFSC 330
            |    |..:...|.|          .|:..:..:.|...:.||            |.|   ::.|
  Fly   283 L----PSKKYKTDYT----------ENSYRAHMKLTIRNLQYG------------DFG---NYRC 318

Mouse   331 VWRGN-------------PLP 338
            :.:.:             |||
  Fly   319 ISKNSLGETEGSIRVYEIPLP 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel2	NP_766486.1	IG	27..116	CDD:214652	24/102 (24%)
		Ig	122..220	CDD:416386	25/98 (26%)
		Ig strand A	123..126	CDD:409353	0/2 (0%)
		Ig strand A'	129..133	CDD:409353	3/4 (75%)
		Ig strand B	140..147	CDD:409353	4/6 (67%)
		Cell attachment site. /evidence=ECO:0000255	146..148		0/1 (0%)
		Ig strand C	153..158	CDD:409353	1/4 (25%)
		Ig strand C'	161..163	CDD:409353	0/1 (0%)
		Ig strand D	166..173	CDD:409353	1/6 (17%)
		Ig strand E	180..188	CDD:409353	1/7 (14%)
		Ig strand F	197..205	CDD:409353	2/7 (29%)
		Ig strand G	211..217	CDD:409353	0/5 (0%)
		Ig_3	223..292	CDD:404760	15/68 (22%)
		Ig strand B	241..245	CDD:409353	2/3 (67%)
		Ig strand C	255..259	CDD:409353	1/3 (33%)
		Ig strand E	272..275	CDD:409353	0/2 (0%)
		Ig strand F	281..290	CDD:409353	0/8 (0%)
		Ig strand G	298..301	CDD:409353	0/2 (0%)
		Ig	315..392	CDD:416386	6/37 (16%)
		Ig strand A'	316..321	CDD:409353	0/4 (0%)
		Ig strand B	324..333	CDD:409353	1/8 (13%)
		Ig strand C	339..343	CDD:409353	81/346 (23%)
		Ig strand C'	346..348	CDD:409353
		Ig strand D	351..354	CDD:409353
		Ig strand E	355..360	CDD:409353
		Ig strand F	368..376	CDD:409353
		Ig strand G	382..392	CDD:409353
		Ig	394..498	CDD:416386
		Ig strand A	395..399	CDD:409353
		Ig strand A'	401..404	CDD:409353
		Ig strand B	412..419	CDD:409353
		Ig strand C	426..431	CDD:409353
		Ig strand C'	433..436	CDD:409353
		Ig strand D	444..451	CDD:409353
		Ig strand E	461..468	CDD:409353
		Ig strand F	479..486	CDD:409353
		Ig strand G	489..496	CDD:409353
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..576
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..700
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	25/103 (24%)
		Ig	145..238	CDD:416386	26/100 (26%)
		Ig strand A	145..149	CDD:409353	1/3 (33%)
		Ig strand A'	154..159	CDD:409353	3/4 (75%)
		Ig strand B	165..172	CDD:409353	4/8 (50%)
		Ig strand C	178..183	CDD:409353	1/4 (25%)
		Ig strand C'	185..187	CDD:409353	1/1 (100%)
		Ig strand D	195..199	CDD:409353	1/3 (33%)
		Ig strand E	203..209	CDD:409353	2/5 (40%)
		Ig strand F	216..223	CDD:409353	2/7 (29%)
		Ig strand G	230..238	CDD:409353	1/7 (14%)
		Ig	242..333	CDD:416386	22/120 (18%)
		Ig strand A'	250..253	CDD:409353	0/2 (0%)
		Ig strand B	259..266	CDD:409353	3/6 (50%)
		Ig strand C	272..277	CDD:409353	2/5 (40%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	1/3 (33%)
		Ig strand E	295..305	CDD:409353	1/9 (11%)
		Ig strand F	314..322	CDD:409353	2/10 (20%)
		Ig strand G	325..334	CDD:409353	0/8 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900