DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kirrel2 and dpr12

DIOPT Version :9

Sequence 1:	NP_766486.1	Gene:	Kirrel2 / 243911	MGIID:	2442334	Length:	700	Species:	Mus musculus
Sequence 2:	NP_652462.3	Gene:	dpr12 / 50320	FlyBaseID:	FBgn0085414	Length:	326	Species:	Drosophila melanogaster

Alignment Length:	272	Identity:	62/272 - (22%)
Similarity:	86/272 - (31%)	Gaps:	84/272 - (30%)

- Green bases have known domain annotations that are detailed below.

Mouse    17 AGSSPHFLQQPED-------MVVLLGEEARLPCAL-GAYRGLVQWTKDGLALGGERDLPGW---- 69
            :..||.|    ||       ..|.||..|.|.|.: |..|..|.|.:  ::....||   |
  Fly    71 SSDSPMF----EDSELMAHNTTVQLGGTAFLVCKVSGVDRVGVNWNQ--ISWIRRRD---WHILS 126

Mouse    70 ---------SRYWISGNSASGQHDLHIKPVELEDEASYECQAS-QAGLRSRPAQLHVMVPPEAPQ 124
                     .|:.|.....|....|.||.|:..|...||||.| ..|:.|....|.|:| ||| .
  Fly   127 SGAQLYTNDERFAILHTPGSNMWTLQIKFVQRRDHGMYECQVSTPTGIISHFVNLQVVV-PEA-F 189

Mouse   125 VLGGPSVSLVAGVPGNLTCRSRGDSRPAPELLWFRDGIRLDGSSFHQTTLKDKATGTVEN----T 185
            :||...:.:..|...||.|.......|...:.|.::               |:....|::    |
  Fly   190 ILGSGELHVDMGSTINLVCIIEKSPTPPQYVYWQKN---------------DRLINYVDSRRDIT 239

Mouse   186 LFLTPSSHDDGATLICRARSQALPTGRDTAVTLSLQYPPMVTLSAEPQTVQEGEKVTFLCQATAQ 250
            :..||........:|                             .|||....|   .:.|.|:..
  Fly   240 IETTPGPRTQSRLII-----------------------------REPQVTDSG---NYTCSASNT 272

Mouse   251 PPVTGYRWAKGG 262
            .|.:.|.:...|
  Fly   273 EPASIYVFVSKG 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel2	NP_766486.1	IG	27..116	CDD:214652	31/110 (28%)
		Ig	122..220	CDD:416386	15/101 (15%)
		Ig strand A	123..126	CDD:409353	0/2 (0%)
		Ig strand A'	129..133	CDD:409353	0/3 (0%)
		Ig strand B	140..147	CDD:409353	3/6 (50%)
		Cell attachment site. /evidence=ECO:0000255	146..148		0/1 (0%)
		Ig strand C	153..158	CDD:409353	0/4 (0%)
		Ig strand C'	161..163	CDD:409353	0/1 (0%)
		Ig strand D	166..173	CDD:409353	0/6 (0%)
		Ig strand E	180..188	CDD:409353	2/11 (18%)
		Ig strand F	197..205	CDD:409353	1/7 (14%)
		Ig strand G	211..217	CDD:409353	0/5 (0%)
		Ig_3	223..292	CDD:404760	9/40 (23%)
		Ig strand B	241..245	CDD:409353	0/3 (0%)
		Ig strand C	255..259	CDD:409353	1/3 (33%)
		Ig strand E	272..275	CDD:409353
		Ig strand F	281..290	CDD:409353
		Ig strand G	298..301	CDD:409353
		Ig	315..392	CDD:416386
		Ig strand A'	316..321	CDD:409353
		Ig strand B	324..333	CDD:409353
		Ig strand C	339..343	CDD:409353
		Ig strand C'	346..348	CDD:409353
		Ig strand D	351..354	CDD:409353
		Ig strand E	355..360	CDD:409353
		Ig strand F	368..376	CDD:409353
		Ig strand G	382..392	CDD:409353
		Ig	394..498	CDD:416386
		Ig strand A	395..399	CDD:409353
		Ig strand A'	401..404	CDD:409353
		Ig strand B	412..419	CDD:409353
		Ig strand C	426..431	CDD:409353
		Ig strand C'	433..436	CDD:409353
		Ig strand D	444..451	CDD:409353
		Ig strand E	461..468	CDD:409353
		Ig strand F	479..486	CDD:409353
		Ig strand G	489..496	CDD:409353
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..576
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..700
dpr12	NP_652462.3	IG	86..183	CDD:214652	29/101 (29%)
		Ig_3	193..271	CDD:404760	18/124 (15%)
		Ig strand B	204..208	CDD:409353	2/3 (67%)
		Ig strand C	219..223	CDD:409353	0/3 (0%)
		Ig strand E	250..254	CDD:409353	0/3 (0%)
		Ig strand F	264..269	CDD:409353	1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900