DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kirrel2 and CG7166

DIOPT Version :9

Sequence 1:	NP_766486.1	Gene:	Kirrel2 / 243911	MGIID:	2442334	Length:	700	Species:	Mus musculus
Sequence 2:	NP_001262181.1	Gene:	CG7166 / 40401	FlyBaseID:	FBgn0037107	Length:	467	Species:	Drosophila melanogaster

Alignment Length:	311	Identity:	74/311 - (23%)
Similarity:	118/311 - (37%)	Gaps:	49/311 - (15%)

- Green bases have known domain annotations that are detailed below.

Mouse    19 SSPHFLQQPEDMVVLLGEEARLPCA---LGAYRGLVQWTKDGLAL-GGERDLPGWSRYWISGNSA 79
            ::|.||.:.....|::||...|||.   ||::  ::.|.|....| .|...:....|:.|.|:
  Fly    37 TAPKFLSRGHLYKVIVGETIELPCKVQNLGSF--VLLWRKGSSVLTAGHLKITRDQRFKIVGD-- 97

Mouse    80 SGQHDLHIKPVELEDEASYECQASQAGLRSRPAQLHVMVPPEAPQVLGGPSVSLVAGVPGNLTCR 144
               ::|.|..|:.:|...|.||......|.:...:.::|||....:.....|:...|....|.|:
  Fly    98 ---YNLQINGVKTQDAGDYICQLGDQENRDQVHTVEILVPPTLRALPHNGQVTARKGSTVTLECK 159

Mouse   145 SRGDSRPAPELLWFRDGIRLDGSSFHQTTLKDKATGTVENTLFLTPSSHDDGATLICRARSQALP 209
            :.|:  |.|.:.||:..: ..|    .|.|.|.:|..:||.     ..|..| |..|.|     .
  Fly   160 ASGN--PVPTIFWFKKDV-FSG----PTHLSDSSTLILENV-----DRHHAG-TYQCSA-----D 206

Mouse   210 TGRDTAVTLSLQY----PPMVTLSAEPQTVQEGEKVTFLC--QATAQPPVTGYRWAKGGSPVLGA 268
            .|....|::.:|.    ||.:|:........||..|..:|  .......:..|:    .|.:|.|
  Fly   207 NGVKDRVSMDIQLTILSPPEITVEKSWVHASEGYDVELVCIVHGDVNSEMLWYQ----NSFLLDA 267

Mouse   269 RGPRLEVVADATFLT-----EPV-----SCEVSNAVGSANRSTALEVLYGP 309
            ...|.....|..:..     :|.     ||...||:|...:...:....||
  Fly   268 TDRRSMYPRDDRYSLIIRNFQPTDFGNYSCVADNALGRTKKYIEVSGRPGP 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel2	NP_766486.1	IG	27..116	CDD:214652	23/92 (25%)
		Ig	122..220	CDD:416386	23/97 (24%)
		Ig strand A	123..126	CDD:409353	0/2 (0%)
		Ig strand A'	129..133	CDD:409353	1/3 (33%)
		Ig strand B	140..147	CDD:409353	2/6 (33%)
		Cell attachment site. /evidence=ECO:0000255	146..148		0/1 (0%)
		Ig strand C	153..158	CDD:409353	1/4 (25%)
		Ig strand C'	161..163	CDD:409353	0/1 (0%)
		Ig strand D	166..173	CDD:409353	1/6 (17%)
		Ig strand E	180..188	CDD:409353	2/7 (29%)
		Ig strand F	197..205	CDD:409353	3/7 (43%)
		Ig strand G	211..217	CDD:409353	1/5 (20%)
		Ig_3	223..292	CDD:404760	16/80 (20%)
		Ig strand B	241..245	CDD:409353	1/3 (33%)
		Ig strand C	255..259	CDD:409353	1/3 (33%)
		Ig strand E	272..275	CDD:409353	1/2 (50%)
		Ig strand F	281..290	CDD:409353	3/18 (17%)
		Ig strand G	298..301	CDD:409353	0/2 (0%)
		Ig	315..392	CDD:416386
		Ig strand A'	316..321	CDD:409353
		Ig strand B	324..333	CDD:409353
		Ig strand C	339..343	CDD:409353
		Ig strand C'	346..348	CDD:409353
		Ig strand D	351..354	CDD:409353
		Ig strand E	355..360	CDD:409353
		Ig strand F	368..376	CDD:409353
		Ig strand G	382..392	CDD:409353
		Ig	394..498	CDD:416386
		Ig strand A	395..399	CDD:409353
		Ig strand A'	401..404	CDD:409353
		Ig strand B	412..419	CDD:409353
		Ig strand C	426..431	CDD:409353
		Ig strand C'	433..436	CDD:409353
		Ig strand D	444..451	CDD:409353
		Ig strand E	461..468	CDD:409353
		Ig strand F	479..486	CDD:409353
		Ig strand G	489..496	CDD:409353
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..576
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..700
CG7166	NP_001262181.1	IG_like	50..133	CDD:214653	23/89 (26%)
		Ig	56..116	CDD:143165	17/66 (26%)
		IG_like	144..221	CDD:214653	24/94 (26%)
		IGc2	151..209	CDD:197706	20/75 (27%)
		IG_like	232..313	CDD:214653	16/84 (19%)
		Ig	242..311	CDD:143165	14/72 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900