DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kirrel2 and dpr10

DIOPT Version :9

Sequence 1:	NP_766486.1	Gene:	Kirrel2 / 243911	MGIID:	2442334	Length:	700	Species:	Mus musculus
Sequence 2:	NP_729591.1	Gene:	dpr10 / 39180	FlyBaseID:	FBgn0052057	Length:	408	Species:	Drosophila melanogaster

Alignment Length:	294	Identity:	60/294 - (20%)
Similarity:	96/294 - (32%)	Gaps:	98/294 - (33%)

- Green bases have known domain annotations that are detailed below.

Mouse    15 GHAGSSPHF-LQQPEDMVVLLGEEARLPCA---LGAYRGLVQWTKDG----LALGG--------- 62
            ||..:.|:| |..|.::..|:|:.|.|.|.   ||  ...|.|.:..    |.:|.
  Fly    47 GHKWNEPYFDLTMPRNITSLVGKSAYLGCRVKHLG--NKTVAWIRHRDLHILTVGTYTYTTDQRF 109

Mouse    63 ----ERDLPGWSRYWISGNSASGQHDLHIKPVELEDEASYECQASQAGLRSRPAQLHVM------ 117
                .||:..|:              |.||..:..|...||||.|...:||....|:::
  Fly   110 QTSYHRDIDEWT--------------LQIKWAQQRDAGVYECQISTQPVRSYSVNLNIVDLIDAE 160

Mouse   118 --------------------------------------VPPEAPQVLGGPSVSLVAGVPGNLTCR 144
                                                  |......:||||.:.:..|...||||.
  Fly   161 TSDIMQQYYNDDAFYIAENRVYQSSNDEFAGMFGPIQTVAVPTATILGGPDLYVDKGSTINLTCI 225

Mouse   145 SRGDSRPAPELLWF-RDGI---RLDGSSFHQTTLKDKATGTVENTLFLTPSSHDDGATLICRARS 205
            .:....|...:.|: :|.:   ...|......|:|.:.|.::   |.:    :|  |.|:...:.
  Fly   226 IKFSPEPPTHIFWYHQDKVLSEETSGGRLKFKTIKSEETKSI---LLI----YD--ADLLHSGKY 281

Mouse   206 QALPTGRDTAV----TLSLQYPPMVTLSAEPQTV 235
            ...|:..:.|.    .|..:.|..:..:|.|..|
  Fly   282 SCYPSNTEIASIRVHVLQGERPEAMQTNAAPAAV 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel2	NP_766486.1	IG	27..116	CDD:214652	27/108 (25%)
		Ig	122..220	CDD:416386	23/105 (22%)
		Ig strand A	123..126	CDD:409353	0/2 (0%)
		Ig strand A'	129..133	CDD:409353	1/3 (33%)
		Ig strand B	140..147	CDD:409353	4/6 (67%)
		Cell attachment site. /evidence=ECO:0000255	146..148		0/1 (0%)
		Ig strand C	153..158	CDD:409353	0/4 (0%)
		Ig strand C'	161..163	CDD:409353	0/4 (0%)
		Ig strand D	166..173	CDD:409353	1/6 (17%)
		Ig strand E	180..188	CDD:409353	1/7 (14%)
		Ig strand F	197..205	CDD:409353	2/7 (29%)
		Ig strand G	211..217	CDD:409353	1/9 (11%)
		Ig_3	223..292	CDD:404760	4/13 (31%)
		Ig strand B	241..245	CDD:409353
		Ig strand C	255..259	CDD:409353
		Ig strand E	272..275	CDD:409353
		Ig strand F	281..290	CDD:409353
		Ig strand G	298..301	CDD:409353
		Ig	315..392	CDD:416386
		Ig strand A'	316..321	CDD:409353
		Ig strand B	324..333	CDD:409353
		Ig strand C	339..343	CDD:409353
		Ig strand C'	346..348	CDD:409353
		Ig strand D	351..354	CDD:409353
		Ig strand E	355..360	CDD:409353
		Ig strand F	368..376	CDD:409353
		Ig strand G	382..392	CDD:409353
		Ig	394..498	CDD:416386
		Ig strand A	395..399	CDD:409353
		Ig strand A'	401..404	CDD:409353
		Ig strand B	412..419	CDD:409353
		Ig strand C	426..431	CDD:409353
		Ig strand C'	433..436	CDD:409353
		Ig strand D	444..451	CDD:409353
		Ig strand E	461..468	CDD:409353
		Ig strand F	479..486	CDD:409353
		Ig strand G	489..496	CDD:409353
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..576
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..700
dpr10	NP_729591.1	Ig	63..143	CDD:299845	23/95 (24%)
		IG_like	210..297	CDD:214653	19/95 (20%)
		IGc2	217..287	CDD:197706	17/78 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900