DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kirrel2 and dpr13

DIOPT Version :9

Sequence 1:	NP_766486.1	Gene:	Kirrel2 / 243911	MGIID:	2442334	Length:	700	Species:	Mus musculus
Sequence 2:	NP_001033956.2	Gene:	dpr13 / 3885598	FlyBaseID:	FBgn0034286	Length:	419	Species:	Drosophila melanogaster

Alignment Length:	427	Identity:	85/427 - (19%)
Similarity:	125/427 - (29%)	Gaps:	139/427 - (32%)

- Green bases have known domain annotations that are detailed below.

Mouse   200 ICRARSQALPTGRDTAVTLSLQYPPMVTLSAEPQT-----------VQEGEKVTFLCQATAQPPV 253
            ||...:.|.|.|..|...      .|.|.::||..           .:|||.|. :.|..||...
  Fly    37 ICDHTASASPGGGKTVAA------TMTTPASEPSVRHINQNLIMSQSKEGEPVP-VPQPYAQSAA 94

Mouse   254 TGYRWAKGGSPVL---------GARGPRLEVVADATFLT----------------------EPVS 287
            :.     |||.:.         |...|....:.:|...|                      |||.
  Fly    95 SA-----GGSSITSFDSTNVIDGQSQPTPTHLQEAVLQTHSHSRIQAKDTAGPYPIPVHRPEPVE 154

Mouse   288 --CEVSNAVGSANRSTALEVLYG-PILQAKPKS--VSVDVGKDASFSCVWRGNPLPRITWTRMGG 347
              .|.:|.:     ...:|.|:| |:......|  |:..:|..|...|.........::|.|...
  Fly   155 NHLEANNGI-----EGGMESLFGTPMYFGTENSTVVTTQIGATAHVPCTVHHIGEGVVSWIRKKD 214

Mouse   348 SQVLSSGP--------------------TLRLPSVALEDAGDYVCRAE---PRRTGLGGGKAQAR 389
            ..:|:.|.                    ||::..|.|.|||.|.|:..   |....|.....:||
  Fly   215 YHLLTVGLTTYSSDERFSATHLKHSEDWTLQIKFVQLRDAGVYECQVSTHPPTSIFLHLSVVEAR 279

Mouse   390 LTVNAPPVVTALQPAPAFLRGPARLQC-VVFASPAPDSVVWSWDEGFLEAGSLGRFLVEAFPAPE 453
            ..:..|| :..|.|....     |||| ||..:.|.:.:.|..|...:
  Fly   280 AEITGPP-IRYLTPGSTL-----RLQCRVVQNTEASEYIFWYHDNRMI----------------- 321

Mouse   454 VEGGQGPGLISVLHISGTQESDFTTGFNCSARNRLGEGRVQIHLGRRDLLPTVRIVAGAASAATS 518
                               ..|...|.|.|.........:.|...||:.......||.....|:.
  Fly   322 -------------------NYDIDRGINVSTEPDFQSSELTIQRTRREHSGNFTCVASNTQPASV 367

Mouse   519 LLMVITGVVLCCWRHGSLSKQKNLVRIPGSSEGSSSR 555
            |:.:..|.......||         .:.||::.:.|:
  Fly   368 LVHIFKGDNPAAMYHG---------HVGGSTKTTQSQ 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel2	NP_766486.1	IG	27..116	CDD:214652
		Ig	122..220	CDD:416386	6/19 (32%)
		Ig strand A	123..126	CDD:409353
		Ig strand A'	129..133	CDD:409353
		Ig strand B	140..147	CDD:409353
		Cell attachment site. /evidence=ECO:0000255	146..148
		Ig strand C	153..158	CDD:409353
		Ig strand C'	161..163	CDD:409353
		Ig strand D	166..173	CDD:409353
		Ig strand E	180..188	CDD:409353
		Ig strand F	197..205	CDD:409353	2/4 (50%)
		Ig strand G	211..217	CDD:409353	2/5 (40%)
		Ig_3	223..292	CDD:404760	22/112 (20%)
		Ig strand B	241..245	CDD:409353	1/3 (33%)
		Ig strand C	255..259	CDD:409353	0/3 (0%)
		Ig strand E	272..275	CDD:409353	0/2 (0%)
		Ig strand F	281..290	CDD:409353	4/32 (13%)
		Ig strand G	298..301	CDD:409353	0/2 (0%)
		Ig	315..392	CDD:416386	22/101 (22%)
		Ig strand A'	316..321	CDD:409353	2/6 (33%)
		Ig strand B	324..333	CDD:409353	2/8 (25%)
		Ig strand C	339..343	CDD:409353	0/3 (0%)
		Ig strand C'	346..348	CDD:409353	0/1 (0%)
		Ig strand D	351..354	CDD:409353	1/2 (50%)
		Ig strand E	355..360	CDD:409353	2/24 (8%)
		Ig strand F	368..376	CDD:409353	3/10 (30%)
		Ig strand G	382..392	CDD:409353	2/9 (22%)
		Ig	394..498	CDD:416386	18/104 (17%)
		Ig strand A	395..399	CDD:409353	2/3 (67%)
		Ig strand A'	401..404	CDD:409353	1/2 (50%)
		Ig strand B	412..419	CDD:409353	5/7 (71%)
		Ig strand C	426..431	CDD:409353	1/4 (25%)
		Ig strand C'	433..436	CDD:409353	0/2 (0%)
		Ig strand D	444..451	CDD:409353	0/6 (0%)
		Ig strand E	461..468	CDD:409353	0/6 (0%)
		Ig strand F	479..486	CDD:409353	3/6 (50%)
		Ig strand G	489..496	CDD:409353	0/6 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..576		3/14 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..700
dpr13	NP_001033956.2	V-set	180..276	CDD:284989	20/95 (21%)
		IG_like	182..262	CDD:214653	18/79 (23%)
		IG_like	285..362	CDD:214653	22/118 (19%)
		IGc2	292..361	CDD:197706	19/109 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900