DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kirrel2 and CG17716

DIOPT Version :9

Sequence 1:	NP_766486.1	Gene:	Kirrel2 / 243911	MGIID:	2442334	Length:	700	Species:	Mus musculus
Sequence 2:	NP_001286391.1	Gene:	CG17716 / 36521	FlyBaseID:	FBgn0000633	Length:	822	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	120/518 - (23%)
Similarity:	180/518 - (34%)	Gaps:	121/518 - (23%)

- Green bases have known domain annotations that are detailed below.

Mouse    26 QPEDMVVLLGE---EARLPCALGAYRGLVQWTKDGL---ALGGERDLPGWSRYWISGNSASGQHD 84
            :.|:|.|:..|   |.:|.|.:........|.|:|.   |:.....:..: |:....|.|
  Fly   239 EAEEMSVVYAEQHSEIKLMCEVDLDIATSMWYKNGQVVHAMDRTARVTDY-RFIKEANGA----- 297

Mouse    85 LHIKPVELEDEASYECQASQAGL---RSRPAQLHVMVPPEAPQVL--------GGPSVSLVAGVP 138
            |.|..|.|||:..::|:|.....   .:||.:|.|:..|:.|.:|        ....|.:.....
  Fly   298 LTITNVMLEDDGKWQCEAENTRRYTENARPVKLVVLDRPKPPYLLIDSRRLDASNLFVPVKENSE 362

Mouse   139 GNLTCRSRGDSRPAPELLW---FRDGI---------------RLDGSSFHQTTLKDKATGTVENT 185
            .||.|.|.| ..|.|.|.|   ...|:               .:.|....:...|..:....|..
  Fly   363 LNLACVSEG-GNPRPTLTWEVLLSPGVDRHAQKVSAEVLELEEIKGEKLDKDGYKINSGAKSEAR 426

Mouse   186 LFLTPSSHDDGATLICRARSQALPTGRDTAVTLSLQYPPMVTLSAEP---QTVQEGEKVTFLCQA 247
            |.....:|.: |.::|......|...::.::.|.:||.|...:|..|   ..::||.:|:..|..
  Fly   427 LPAVYRAHHN-ARILCVMEHPTLKIRQNASLLLDVQYTPSFAISRTPGFGYPLREGIEVSLKCDV 490

Mouse   248 TAQPPVTGYRWAK--GGSPV-------------------------------LGARGPRLEVVADA 279
            .:.||.|. ||.|  |.:||                               ..:.|..|.|..|:
  Fly   491 DSNPPSTP-RWQKDDGDTPVPQTGDGFLNFTSIRREHSGWYKCTSRHLNFQYSSIGYYLSVRFDS 554

Mouse   280 TFLT-EPVSCEVSNAVGSANRSTA-LEV-LYGPILQAKPKSVSVDVGKDASFSCVWRGNPLPRIT 341
            ..:| ||...:||.|..|.|.:.. ||| |.|.:....|:         .|..|....:|:.
  Fly   555 VDVTSEPDDQDVSVAAASHNPNKGQLEVQLGGAVTLQCPQ---------GSLGCWSHLDPIS--- 607

Mouse   342 WTRMGGSQVLSSGPT--LRLPSVALEDAGDYVCRAEPRRTGLGGGKAQAR---------LTVNAP 395
             .|:.|....||.||  ..|..|..:|||.|.|        :|......:         ::|...
  Fly   608 -ARLRGLGYGSSQPTGQFSLKDVMYQDAGMYKC--------VGQSPTNKKKLEVLQSVTVSVKGA 663

Mouse   396 PVVTALQPAP-AFLRGPARLQCVVFASPAPDSVVW-SWDEGFLEAGSLG----RFLVEAFPAP 452
            |.|.||...| |:...|..|.....|:|...:..| ..|..|......|    .:.|:..|.|
  Fly   664 PTVMALNATPVAYPGSPLHLNVEFCANPPAHAARWLHGDRVFTPGNQYGTTVLAYAVKDLPTP 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel2	NP_766486.1	IG	27..116	CDD:214652	25/97 (26%)
		Ig	122..220	CDD:416386	22/123 (18%)
		Ig strand A	123..126	CDD:409353	1/2 (50%)
		Ig strand A'	129..133	CDD:409353	1/3 (33%)
		Ig strand B	140..147	CDD:409353	4/6 (67%)
		Cell attachment site. /evidence=ECO:0000255	146..148		0/1 (0%)
		Ig strand C	153..158	CDD:409353	3/7 (43%)
		Ig strand C'	161..163	CDD:409353	1/16 (6%)
		Ig strand D	166..173	CDD:409353	1/6 (17%)
		Ig strand E	180..188	CDD:409353	2/7 (29%)
		Ig strand F	197..205	CDD:409353	2/7 (29%)
		Ig strand G	211..217	CDD:409353	0/5 (0%)
		Ig_3	223..292	CDD:404760	24/105 (23%)
		Ig strand B	241..245	CDD:409353	1/3 (33%)
		Ig strand C	255..259	CDD:409353	1/3 (33%)
		Ig strand E	272..275	CDD:409353	1/2 (50%)
		Ig strand F	281..290	CDD:409353	3/9 (33%)
		Ig strand G	298..301	CDD:409353	1/2 (50%)
		Ig	315..392	CDD:416386	18/87 (21%)
		Ig strand A'	316..321	CDD:409353	0/4 (0%)
		Ig strand B	324..333	CDD:409353	2/8 (25%)
		Ig strand C	339..343	CDD:409353	0/3 (0%)
		Ig strand C'	346..348	CDD:409353	0/1 (0%)
		Ig strand D	351..354	CDD:409353	1/2 (50%)
		Ig strand E	355..360	CDD:409353	2/6 (33%)
		Ig strand F	368..376	CDD:409353	3/7 (43%)
		Ig strand G	382..392	CDD:409353	1/18 (6%)
		Ig	394..498	CDD:416386	17/65 (26%)
		Ig strand A	395..399	CDD:409353	1/3 (33%)
		Ig strand A'	401..404	CDD:409353	1/2 (50%)
		Ig strand B	412..419	CDD:409353	1/6 (17%)
		Ig strand C	426..431	CDD:409353	1/5 (20%)
		Ig strand C'	433..436	CDD:409353	0/2 (0%)
		Ig strand D	444..451	CDD:409353	1/6 (17%)
		Ig strand E	461..468	CDD:409353
		Ig strand F	479..486	CDD:409353
		Ig strand G	489..496	CDD:409353
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..576
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..700
CG17716	NP_001286391.1	IG_like	244..332	CDD:214653	23/93 (25%)
		Ig	254..323	CDD:143165	17/74 (23%)
		Ig	359..452	CDD:299845	18/94 (19%)
		Ig_3	477..536	CDD:290638	13/59 (22%)
		IG_like	479..550	CDD:214653	15/71 (21%)
		IG_like	578..660	CDD:214653	23/102 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910