DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kirrel2 and dpr19

DIOPT Version :9

Sequence 1:	NP_766486.1	Gene:	Kirrel2 / 243911	MGIID:	2442334	Length:	700	Species:	Mus musculus
Sequence 2:	NP_001260336.1	Gene:	dpr19 / 34408	FlyBaseID:	FBgn0032233	Length:	385	Species:	Drosophila melanogaster

Alignment Length:	387	Identity:	82/387 - (21%)
Similarity:	133/387 - (34%)	Gaps:	106/387 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse   290 VSNAVGSANRSTALEVLYGPILQAKPKS-----VSVDVGKDASFSCVWRGNPLPRITWTRMGGSQ 349
            :|:......:.|:.:..:|..||::..:     |....|..|...||.:.|....::|.|....|
  Fly    17 LSSTFSDVGKITSSQNHFGNTLQSQFNTKNNTRVIAQKGGLAILPCVVKVNSPATVSWIRRKDFQ 81

Mouse   350 VLSSGP--------------------TLRLPSVALEDAGDYVCRAE--PRRTGLGGGKAQARLTV 392
            :|:.|.                    :||:.:|..||.|.|.|:..  |.::.:        :.:
  Fly    82 LLTVGLSTHSSDKRFLVEHTRHMGHWSLRIKAVREEDRGFYECQLSIYPTQSIV--------IEL 138

Mouse   393 NAPPVVTALQPAPAF---LRGPARLQC-VVFASPAPDSVVWSWDEGFLEAGSLGRFLVEAFPAPE 453
            .....|..:..||..   .....||:| :..|:..|..|.|..|...:...|.|.|:|.:.....
  Fly   139 KIVEAVAEISSAPELHIDETSTLRLECKLKRATENPAFVFWYHDSKMINYDSQGGFVVTSIGQSN 203

Mouse   454 VEGGQGPGLISVLHISGTQESDFTTGFNCSARNRLGEGRVQIHLGRRDLLPTVRIVAGAASAATS 518
            .:.||      ....|...:|..|.....|      .|.:...||..|     .|.|.||:..:|
  Fly   204 PQSGQ------FYRSSPANKSRATMPMESS------NGVLNSLLGSSD-----AIKAPAANVPSS 251

Mouse   519 L----------------LMVITGVVLCCWRHGSLSKQKNLVRIPGSSEGSS-----SRGPEEETG 562
            .                :.|:| |....:||..     |....|.::..:|     .||  |:|.
  Fly   252 TPYMTQQHQSAYLLNPSVSVLT-VKQVNFRHAG-----NYTCAPSNARPASITVHVLRG--EKTA 308

Mouse   563 SSEDRGPIVHTDHSDLVLEEKEALETKDPTNGYY------RVRGVS-VSLSLGEAPGGGLFL 617
            :.:      |.:.|        .|:|:...||.:      .:.|.| |:|:.|.....||||
  Fly   309 AMQ------HANRS--------ILDTETNGNGTFGLITLGGLNGTSGVTLAGGILYFSGLFL 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel2	NP_766486.1	IG	27..116	CDD:214652
		Ig	122..220	CDD:416386
		Ig strand A	123..126	CDD:409353
		Ig strand A'	129..133	CDD:409353
		Ig strand B	140..147	CDD:409353
		Cell attachment site. /evidence=ECO:0000255	146..148
		Ig strand C	153..158	CDD:409353
		Ig strand C'	161..163	CDD:409353
		Ig strand D	166..173	CDD:409353
		Ig strand E	180..188	CDD:409353
		Ig strand F	197..205	CDD:409353
		Ig strand G	211..217	CDD:409353
		Ig_3	223..292	CDD:404760	0/1 (0%)
		Ig strand B	241..245	CDD:409353
		Ig strand C	255..259	CDD:409353
		Ig strand E	272..275	CDD:409353
		Ig strand F	281..290	CDD:409353	82/387 (21%)
		Ig strand G	298..301	CDD:409353	0/2 (0%)
		Ig	315..392	CDD:416386	20/103 (19%)
		Ig strand A'	316..321	CDD:409353	1/9 (11%)
		Ig strand B	324..333	CDD:409353	3/8 (38%)
		Ig strand C	339..343	CDD:409353	0/3 (0%)
		Ig strand C'	346..348	CDD:409353	0/1 (0%)
		Ig strand D	351..354	CDD:409353	1/2 (50%)
		Ig strand E	355..360	CDD:409353	2/24 (8%)
		Ig strand F	368..376	CDD:409353	3/9 (33%)
		Ig strand G	382..392	CDD:409353	0/9 (0%)
		Ig	394..498	CDD:416386	22/107 (21%)
		Ig strand A	395..399	CDD:409353	0/3 (0%)
		Ig strand A'	401..404	CDD:409353	0/2 (0%)
		Ig strand B	412..419	CDD:409353	3/7 (43%)
		Ig strand C	426..431	CDD:409353	2/4 (50%)
		Ig strand C'	433..436	CDD:409353	0/2 (0%)
		Ig strand D	444..451	CDD:409353	2/6 (33%)
		Ig strand E	461..468	CDD:409353	0/6 (0%)
		Ig strand F	479..486	CDD:409353	1/6 (17%)
		Ig strand G	489..496	CDD:409353	1/6 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..576		7/38 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..700
dpr19	NP_001260336.1	IG_like	50..127	CDD:214653	19/76 (25%)
dpr19	NP_001260336.1	IGc2	55..125	CDD:197706	17/69 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900