DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kirrel2 and DIP-theta

DIOPT Version :9

Sequence 1:	NP_766486.1	Gene:	Kirrel2 / 243911	MGIID:	2442334	Length:	700	Species:	Mus musculus
Sequence 2:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster

Alignment Length:	645	Identity:	124/645 - (19%)
Similarity:	203/645 - (31%)	Gaps:	227/645 - (35%)

- Green bases have known domain annotations that are detailed below.

Mouse    21 PHFLQQPEDMVVLLGEEARLPCA---LGAYRGLVQW----TKDGLAL--------------GGER 64
            |.|.:..:::.|.:..||.|.|.   |..|:  :.|    |:..|.:              ..|:
  Fly   130 PKFGELLQNVTVPVSREAVLQCVVDNLQTYK--IAWLRVDTQTILTIQNHVITKNHRMSITHAEK 192

Mouse    65 DLPGWSRYWISGNSASGQHDLHIKPVELEDEASYECQASQAGLRSRPAQLHVMVPPEAPQVLGGP 129
                  |.||          |.|:.|:..|:..|.||.:...::|:...|.|:|||:   :|..|
  Fly   193 ------RAWI----------LRIRDVKESDKGWYMCQINTDPMKSQVGYLDVVVPPD---ILDYP 238

Mouse   130 -SVSLVAGVPGNLTCRSRGDSRPAPELLWFRDGIRLDGSSFHQTTLKDKATGTVENTLFLTPSSH 193
             |..:|.....|:|.:......|.|.:.|.|:|..|       ..|.:.|.....|..|||.:..
  Fly   239 TSTDMVIREGSNVTLKCAATGSPTPTITWRREGGEL-------IPLPNGAEAVAYNGSFLTIAKV 296

Mouse   194 DD---GATLICRARSQALPTGRDTAVTLSLQYPPMVTLSAEPQTVQEGEKVTFLCQATAQPPVTG 255
            :.   ||.| |.| |..:|......|.|.:.:|||:.:..:.......:.:|..||:.|.|....
  Fly   297 NRLNMGAYL-CIA-SNGIPPTVSKRVMLIVHFPPMIWIQNQLVGAALTQNITLECQSEAYPKSIN 359

Mouse   256 YRWAKGGSPVL-GARGPRLEVVADATFLTEPVSCEVSNAVGSANRSTALEVLYGPILQAKPKSVS 319
            | |.|..:.:: |.|           |:.|
  Fly   360 Y-WMKNDTIIVPGER-----------FVPE----------------------------------- 377

Mouse   320 VDVGKDASFSCVWRGNPLPRITWTRMGGSQVLSSGPTLRLP--SVALEDAGDYVCRAEPRRTGLG 382
                                   |...|.::     |:||.  .|.::|.|.|.|.|   :..||
  Fly   378 -----------------------TFESGYKI-----TMRLTIYEVDIQDFGAYRCVA---KNSLG 411

Mouse   383 GGKAQARLTVNAPPVVTALQPAPAFLRGPARLQCVVFASPAPDSVV-WSWDEGFLEAGSLGRFLV 446
            ......:| .:.|...|....||           .|..:..|..:| ::.::.:
  Fly   412 DTDGAIKL-YHIPQTTTMTTMAP-----------TVSINTVPVVLVKYNKEQRY----------- 453

Mouse   447 EAFPAPEVEGGQGPGLISVLHISGTQESDFTTGFNCSARNRLGEGRVQIHLGRRDLLPTVRIVAG 511
                                   |:.::..|..:|.:..|  .:...::..|:.:       ..|
  Fly   454 -----------------------GSSQNSNTNPYNFNPGN--SQQNTKLQRGKSN-------SKG 486

Mouse   512 AASAATSLLMVITGVVLCCW----RHGSLSKQKNLVRIPGSSEGSSSRG---------PEEETGS 563
            :..:.:.|..|..|.....|    .|.|.|          ||..:||||         .:::...
  Fly   487 SDQSPSGLNNVFVGATSSLWNSQDHHSSSS----------SSSSASSRGRDHHQQQHHQQQQQNH 541

Mouse   564 SEDRGPIVHTDHSDLVLEEKEALETKDPTNGYYRVRGVSVSLSLGEAPGGGLFLPPPSPI 623
            ..|.|....:|.....|...:|....|..:....::|.:..||            |.|||
  Fly   542 GSDHGASYRSDGKSPHLTNHDAKSLTDDLDRMQDLKGWASRLS------------PISPI 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel2	NP_766486.1	IG	27..116	CDD:214652	23/109 (21%)
		Ig	122..220	CDD:416386	27/101 (27%)
		Ig strand A	123..126	CDD:409353	0/2 (0%)
		Ig strand A'	129..133	CDD:409353	2/4 (50%)
		Ig strand B	140..147	CDD:409353	2/6 (33%)
		Cell attachment site. /evidence=ECO:0000255	146..148		0/1 (0%)
		Ig strand C	153..158	CDD:409353	1/4 (25%)
		Ig strand C'	161..163	CDD:409353	1/1 (100%)
		Ig strand D	166..173	CDD:409353	0/6 (0%)
		Ig strand E	180..188	CDD:409353	1/7 (14%)
		Ig strand F	197..205	CDD:409353	4/7 (57%)
		Ig strand G	211..217	CDD:409353	0/5 (0%)
		Ig_3	223..292	CDD:404760	15/69 (22%)
		Ig strand B	241..245	CDD:409353	1/3 (33%)
		Ig strand C	255..259	CDD:409353	1/3 (33%)
		Ig strand E	272..275	CDD:409353	0/2 (0%)
		Ig strand F	281..290	CDD:409353	2/8 (25%)
		Ig strand G	298..301	CDD:409353	0/2 (0%)
		Ig	315..392	CDD:416386	14/78 (18%)
		Ig strand A'	316..321	CDD:409353	0/4 (0%)
		Ig strand B	324..333	CDD:409353	0/8 (0%)
		Ig strand C	339..343	CDD:409353	0/3 (0%)
		Ig strand C'	346..348	CDD:409353	0/1 (0%)
		Ig strand D	351..354	CDD:409353	0/2 (0%)
		Ig strand E	355..360	CDD:409353	2/4 (50%)
		Ig strand F	368..376	CDD:409353	4/7 (57%)
		Ig strand G	382..392	CDD:409353	2/9 (22%)
		Ig	394..498	CDD:416386	11/104 (11%)
		Ig strand A	395..399	CDD:409353	1/3 (33%)
		Ig strand A'	401..404	CDD:409353	0/2 (0%)
		Ig strand B	412..419	CDD:409353	0/6 (0%)
		Ig strand C	426..431	CDD:409353	1/5 (20%)
		Ig strand C'	433..436	CDD:409353	0/2 (0%)
		Ig strand D	444..451	CDD:409353	0/6 (0%)
		Ig strand E	461..468	CDD:409353	0/6 (0%)
		Ig strand F	479..486	CDD:409353	1/6 (17%)
		Ig strand G	489..496	CDD:409353	0/6 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..576		9/42 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..700
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	24/110 (22%)
		IG_like	137..230	CDD:214653	24/110 (22%)
		IG_like	240..324	CDD:214653	25/92 (27%)
		IGc2	247..310	CDD:197706	19/71 (27%)
		Ig	327..419	CDD:299845	28/169 (17%)
		IG_like	343..420	CDD:214653	26/155 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900