DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kirrel2 and DIP-beta

DIOPT Version :9

Sequence 1:	NP_766486.1	Gene:	Kirrel2 / 243911	MGIID:	2442334	Length:	700	Species:	Mus musculus
Sequence 2:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	120/548 - (21%)
Similarity:	195/548 - (35%)	Gaps:	130/548 - (23%)

- Green bases have known domain annotations that are detailed below.

Mouse    21 PHFLQQPEDMVVLLGEEARLPCA---LGAYR---------GLVQWTK-DGLALGGERDLPGWSRY 72
            |.|:...|::.:..|.:|...|.   ||.:|         ..|.|.| |..|:....:      :
  Fly    98 PDFVIPLENVTIAQGRDATFTCVVNNLGGHRVSGDGSSAPAKVAWIKADAKAILAIHE------H 156

Mouse    73 WISGNS-ASGQHD------LHIKPVELEDEASYECQASQAGLRSRPAQLHVMVPPEAPQVLGGPS 130
            .|:.|. .|.||:      |:|:.|::||...|.||.:...::.:.|.|.|::||:.........
  Fly   157 VITNNDRLSVQHNDYNTWTLNIRGVKMEDAGKYMCQVNTDPMKMQTATLEVVIPPDIINEETSGD 221

Mouse   131 VSLVAGVPGNLTCRSRGDSRPAPELLWFR-DG---IRLDGSSFHQTTLKDKATGTVENTLFLTPS 191
            :.:..|....|.||:||  .|.|::.|.| ||   |..:||  ||   |.||.......|.|:..
  Fly   222 MMVPEGGSAKLVCRARG--HPKPKITWRREDGREIIARNGS--HQ---KTKAQSVEGEMLTLSKI 279

Mouse   192 SHDDGATLICRARSQALPTGRDTAVTLSLQYPPMVTLSAEPQTVQEGEKVTFLCQATAQPPVTGY 256
            :..:....:|.| |..:|......:.|.:.:.|:|.:..:.........||.:|...|.|....|
  Fly   280 TRSEMGAYMCIA-SNGVPPTVSKRMKLQVHFHPLVQVPNQLVGAPVLTDVTLICNVEASPKAINY 343

Mouse   257 RWAKGGSPVLGARGPRLEVVADATFLTEPVSCEVSNAVGSANRSTALEVLYGPILQAKPKSVSVD 321
             |.:....::        :..|...|||           ..|...|:|:    ||..| :..|.|
  Fly   344 -WQRENGEMI--------IAGDRYALTE-----------KENNMYAIEM----ILHIK-RLQSSD 383

Mouse   322 VGKDASFSCVWRGNPLPRITWTRMGGSQVLSSGPTLRLPSVALEDAGDYVCRAEPRRTGLGGGKA 386
            .|   .:.|:.:.:         :|.::     .|:||  ..:|..|..:.|.:
  Fly   384 FG---GYKCISKNS---------IGDTE-----GTIRL--YEMERPGKKILRDD----------- 418

Mouse   387 QARLTVNAPPVVTALQPAPAFLRGPARLQCVVFASPAPDSVVWSWDEGFLEAGS---LGRFLVEA 448
                .:|.......:|.......|...|...::...|||....|..:..|..|:   :|.||:..
  Fly   419 ----DLNEVSKNEVVQKDTRSEDGSRNLNGRLYKDRAPDQHPASGSDQLLGRGTMRLIGTFLLAL 479

Mouse   449 FPAPEVEGGQGPGLISVLHISGTQESDFTTGFNCSARNRLGEGRVQIHLGRRDLLPTVRIVAGAA 513
            ..........||..:|.....|.|:....|.:|         || :...||.|         |.|
  Fly   480 LVLFTALAEAGPTTLSCRTKGGRQKKAKETSWN---------GR-RARDGRED---------GHA 525

Mouse   514 SAATSLLMVITGVVLCCWRHGSLSKQKN 541
            :....           ||...:||.:::
  Fly   526 AEWRQ-----------CWERSALSWRRS 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kirrel2	NP_766486.1	IG	27..116	CDD:214652	27/108 (25%)
		Ig	122..220	CDD:416386	27/101 (27%)
		Ig strand A	123..126	CDD:409353	0/2 (0%)
		Ig strand A'	129..133	CDD:409353	0/3 (0%)
		Ig strand B	140..147	CDD:409353	3/6 (50%)
		Cell attachment site. /evidence=ECO:0000255	146..148		1/1 (100%)
		Ig strand C	153..158	CDD:409353	1/4 (25%)
		Ig strand C'	161..163	CDD:409353	1/4 (25%)
		Ig strand D	166..173	CDD:409353	4/6 (67%)
		Ig strand E	180..188	CDD:409353	1/7 (14%)
		Ig strand F	197..205	CDD:409353	2/7 (29%)
		Ig strand G	211..217	CDD:409353	0/5 (0%)
		Ig_3	223..292	CDD:404760	13/68 (19%)
		Ig strand B	241..245	CDD:409353	2/3 (67%)
		Ig strand C	255..259	CDD:409353	1/3 (33%)
		Ig strand E	272..275	CDD:409353	0/2 (0%)
		Ig strand F	281..290	CDD:409353	3/8 (38%)
		Ig strand G	298..301	CDD:409353	1/2 (50%)
		Ig	315..392	CDD:416386	11/76 (14%)
		Ig strand A'	316..321	CDD:409353	1/4 (25%)
		Ig strand B	324..333	CDD:409353	1/8 (13%)
		Ig strand C	339..343	CDD:409353	0/3 (0%)
		Ig strand C'	346..348	CDD:409353	1/1 (100%)
		Ig strand D	351..354	CDD:409353	0/2 (0%)
		Ig strand E	355..360	CDD:409353	2/4 (50%)
		Ig strand F	368..376	CDD:409353	2/7 (29%)
		Ig strand G	382..392	CDD:409353	0/9 (0%)
		Ig	394..498	CDD:416386	21/106 (20%)
		Ig strand A	395..399	CDD:409353	0/3 (0%)
		Ig strand A'	401..404	CDD:409353	1/2 (50%)
		Ig strand B	412..419	CDD:409353	1/6 (17%)
		Ig strand C	426..431	CDD:409353	0/4 (0%)
		Ig strand C'	433..436	CDD:409353	0/2 (0%)
		Ig strand D	444..451	CDD:409353	2/6 (33%)
		Ig strand E	461..468	CDD:409353	1/6 (17%)
		Ig strand F	479..486	CDD:409353	1/6 (17%)
		Ig strand G	489..496	CDD:409353	2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..576		120/548 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..700
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	30/116 (26%)
		ig	102..195	CDD:278476	25/98 (26%)
		IG_like	219..307	CDD:214653	27/95 (28%)
		Ig	221..307	CDD:299845	27/93 (29%)
		Ig	311..404	CDD:299845	25/134 (19%)
		IG_like	327..405	CDD:214653	25/121 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810