DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gfap and LamC

DIOPT Version :9

Sequence 1:	NP_058705.2	Gene:	Gfap / 24387	RGDID:	2679	Length:	430	Species:	Rattus norvegicus
Sequence 2:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster

Alignment Length:	431	Identity:	134/431 - (31%)
Similarity:	204/431 - (47%)	Gaps:	81/431 - (18%)

- Green bases have known domain annotations that are detailed below.

  Rat     1 MERRRIT-SARRSYASSETMVRGHGPTRHLGTIPRLSLSRMTPPLPARVDFSLAGALNAGFKETR 64
            |..||:| :.|.|.||:.|.|.|...:..:|.        .:|..|.|.              :|
  Fly     1 MSARRVTLNTRVSRASTSTPVGGASTSSRVGA--------TSPTSPTRT--------------SR 43

  Rat    65 ASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLR---AKEPTKLADVYQAELRELRLRLD 126
            ..|:.|:..||||.|.||:::|.||.:|..|..|||..:   .:|.:.|..||:.||...|..||
  Fly    44 QQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQDTVNRETSNLKAVYEKELAAARKLLD 108

  Rat   127 QLTTNSARLEVERDNLTQDLGTLRQKLQDETNLRLEAENNLAVY--------------------- 170
            :.....|:||::...|.::...|:.:|..:|.....||||..:|
  Fly   109 ETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLADRKKF 173

  Rat   171 ---------------------RQEADEATLARVDLERKVESLEEEIQFLRKIHEEEVRELQEQLA 214
                                 |::.:..||||||||.:.:||.||:.|..::|   .:||.|..:
  Fly   174 EDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVH---TQELTETRS 235

  Rat   215 QQQVHV-EMD-------VAKPDLTAALREIRTQYEAVATSNMQETEEWYRSKFADLTDVASRNAE 271
            ::|:.: |:|       .||  |..:|:|:|.|||.....|.:|.|..|.::..:|...|:|.|:
  Fly   236 RRQIEISEIDGRLSRQYEAK--LQQSLQELRDQYEGQMRINREEIELLYDNEIQNLKAAANRAAQ 298

  Rat   272 LLRQAKHEANDYRRQLQALTCDLESLRGTNESLERQMREQEERHARESASYQEALARLEEEGQSL 336
            ....|..|....|.::..|...|::|..||..|..::||.|.....|...:.:.:|.||.|.|.:
  Fly   299 GSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAELQRM 363

  Rat   337 KEEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITI 377
            ::|||..|||||.|:::|::||:|||.|.|||.|||.|:.|
  Fly   364 RDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNI 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gfap	NP_058705.2	Head	1..70		17/69 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		11/30 (37%)
		Filament_head	4..64	CDD:282575	14/60 (23%)
		Filament	66..374	CDD:278467	116/360 (32%)
		Coil 1A	71..102		15/30 (50%)
		Linker 1	103..113		2/12 (17%)
		Coil 1B	114..212		35/139 (25%)
		Linker 12	213..228		5/22 (23%)
		Coil 2A	229..250		8/20 (40%)
		Linker 2	251..254		1/2 (50%)
		Coil 2B	255..375		45/119 (38%)
		Tail	376..430		1/2 (50%)
LamC	NP_001260974.1	Filament	45..401	CDD:278467	116/360 (32%)
		ATP-synt_B	<67..>142	CDD:304375	23/74 (31%)
		MreC	<178..>224	CDD:302802	14/45 (31%)
		LTD	473..574	CDD:279300
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910