DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gad2 and b

DIOPT Version :9

Sequence 1:	NP_036695.1	Gene:	Gad2 / 24380	RGDID:	2653	Length:	585	Species:	Rattus norvegicus
Sequence 2:	NP_001246025.1	Gene:	b / 34791	FlyBaseID:	FBgn0000153	Length:	575	Species:	Drosophila melanogaster

Alignment Length:	547	Identity:	238/547 - (43%)
Similarity:	355/547 - (64%)	Gaps:	16/547 - (2%)

- Green bases have known domain annotations that are detailed below.

  Rat    46 ALLYGDSEKPAESGGSVTSRAATRKVACTC-----DQKPCSCPKGDV-NYALLHATDLLPACEGE 104
            |.|...:..||:|..:|....|::.:|...     :....:..|.|: ::...|     ||.|.|
  Fly    38 AALVASTSSPADSTSTVAFEQASKMLANAANNNNNNNNNITSTKDDLSSFVASH-----PAAEFE 97

  Rat   105 RPTLAFLQDVMNILLQYVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILTHCQTTLKY 169
            ....|.:.:::.:.   |.:..:||:||:::|.|.||.|.::::|.:|.::.:::....:.|:::
  Fly    98 GFIRACVDEIIKLA---VFQGTNRSSKVVEWHEPAELRQLFDFQLREQGESQDKLRELLRETIRF 159

  Rat   170 AIKTGHPRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWP-GG 233
            ::|||||.:.|||.:|:|...|...|||...|.:::|||:||:|.|:|...|.:||.|:|:| ||
  Fly   160 SVKTGHPYFINQLYSGVDPYALVGQWLTDALNPSVYTYEVAPLFTLMEEQVLAEMRRIVGFPNGG 224

  Rat   234 SGDGIFSPGGAISNMYAMLIARYKMFPEVKEKGMAAVPRLIAFTSEHSHFSLKKGAAALGIGTDS 298
            .|||||.|||:|:|.||:..|||:..||.|:.|:.....||.||||.:|:|::|.|..:|.|:|.
  Fly   225 QGDGIFCPGGSIANGYAISCARYRHSPESKKNGLFNAKPLIIFTSEDAHYSVEKLAMFMGFGSDH 289

  Rat   299 VILIKCDERGKMIPSDLERRILEVKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHV 363
            |..|..:|.|||..||||:::....:.|:.|.:|||||||||.||||.|..::::||||.:||||
  Fly   290 VRKIATNEVGKMRLSDLEKQVKLCLENGWQPLMVSATAGTTVLGAFDDLAGISEVCKKYNMWMHV 354

  Rat   364 DAAWGGGLLMSRKHKWKLNGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQSCNQMHASYLFQ 428
            |||||||.|||:|::..|||:|||:||||||||::....|||..|.|.:.::..|:..:|:||||
  Fly   355 DAAWGGGALMSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVLAQCHSTNATYLFQ 419

  Rat   429 QDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHIDKCLELAEYLYNIIKNREGYEM 493
            :||.||.|:|||||.:||||..||||.|.||:||||.|.|||::|...:||:....::.|.|:|:
  Fly   420 KDKFYDTSFDTGDKHIQCGRRADVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFEL 484

  Rat   494 VFDGKPQHTNVCFWFVPPSLRVLEDNEERMSRLSKVAPVIKARMMEYGTTMVSYQPLGDKVNFFR 558
            |.: .|:.||:.||:|||.||.:|.|.|...||.||||.:|..|::.|:.|::||||....||||
  Fly   485 VLE-SPECTNISFWYVPPGLREMERNREFYDRLHKVAPKVKEGMIKKGSMMITYQPLRQLPNFFR 548

  Rat   559 MVISNPAATHQDIDFLIEEIERLGQDL 585
            :|:.|......|:.:.::|||.|.|:|
  Fly   549 LVLQNSCLEESDMVYFLDEIESLAQNL 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gad2	NP_036695.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Pyridoxal_deC	138..509	CDD:278699	181/371 (49%)
		Substrate binding. /evidence=ECO:0000250	181..183		1/1 (100%)
b	NP_001246025.1	AAT_I	128..499	CDD:302748	181/371 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X464
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920