DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ets1 and Ets97D

DIOPT Version :9

Sequence 1:	XP_017450940.1	Gene:	Ets1 / 24356	RGDID:	2583	Length:	529	Species:	Rattus norvegicus
Sequence 2:	NP_001263000.1	Gene:	Ets97D / 43236	FlyBaseID:	FBgn0004510	Length:	484	Species:	Drosophila melanogaster

Alignment Length:	474	Identity:	130/474 - (27%)
Similarity:	193/474 - (40%)	Gaps:	160/474 - (33%)

- Green bases have known domain annotations that are detailed below.

  Rat    56 SSPYSASHPAIARQGPINSFEDPRMTCGFQSSYHQQRPLYPLWDETATQEVPTGLEHCGSDMECA 120
            |.|.:||..:.:.:.||.:                  ||..:..|.:.:|          .:|..
  Fly   139 SPPETASQKSSSSESPIKT------------------PLKRMHKEDSEEE----------SVEGK 175

  Rat   121 DVPLLTPSSKEMMSQALKATFSGFTKEQQRLGIPKDPRQWTETHVRDWVMWAVNEFSLKGVDFQK 185
            ||       |.:::..|.   |.|.:||.||.||:...:||..||..|:.|||.:|.|.|::...
  Fly   176 DV-------KPVLNWVLD---SKFKREQIRLKIPEAANEWTHAHVTYWLEWAVKQFELVGINMSD 230

  Rat   186 FCMNGAALCALGKECFLELAPDFVGDILWEHLEILQKEDVKPYQVNGVNPTYPESRYTSDYFISY 250
            :.|||..|||:..|.|.:..|...|:|.|.||::|:       :.|.|:..:..:.
  Fly   231 WQMNGQELCAMTHEEFNQKLPRDPGNIFWTHLQLLK-------ECNFVSVVHKRAE--------- 279

  Rat   251 GIEHAQCVPPSEFSEPSFITESYQTLHPISSEELLSLKYENDYPSVILRDPLQTDTLQTDYFAIK 315
              |..:...|...|..|..|.|..:|                                    :::
  Fly   280 --EQRKPKQPRIMSANSISTNSGGSL------------------------------------SLE 306

  Rat   316 QEVLTPDNMCMGRASRGKLGGQDSFESIESYDSCDRLTQSWSSQSSFNSLQRVPSYDSFDSEDYP 380
            |.::                 :.|::|::|.||.:..|.| .:.|::.::
  Fly   307 QRIM-----------------RKSYQSVKSSDSVESTTSS-MNPSNYTTI--------------- 338

  Rat   381 AALPNHKPKGTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQSFISWT 445
                                               |...:|.:||||||||:|||......|.|.
  Fly   339 -----------------------------------GSGNNGQVQLWQFLLEILTDCEHTDVIEWV 368

  Rat   446 GDGWEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLL 510
            |...||||:|||.|||.||::||||.||||||||.||||||.::|.|.:|||:.|:|.|||:.|:
  Fly   369 GTEGEFKLTDPDRVARLWGEKKNKPAMNYEKLSRALRYYYDGDMISKVSGKRFAYKFDCDLKLLI 433

  Rat   511 GYTPEELHAMLDVKPDADE 529
            ||...||..::.....|.|
  Fly   434 GYDANELSTLVSEGKTAPE 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ets1	XP_017450940.1	None
Ets97D	NP_001263000.1	GABP-alpha	48..123	CDD:288472
		SAM_PNT-GABP-alpha	184..272	CDD:176084	36/97 (37%)
		ETS	345..429	CDD:197710	52/83 (63%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3806
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243757at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820