DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ces1c and alpha-Est2

DIOPT Version :9

Sequence 1:	XP_006255234.2	Gene:	Ces1c / 24346	RGDID:	2571	Length:	551	Species:	Rattus norvegicus
Sequence 2:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster

Alignment Length:	576	Identity:	172/576 - (29%)
Similarity:	251/576 - (43%)	Gaps:	133/576 - (23%)

- Green bases have known domain annotations that are detailed below.

  Rat    18 ASGHPSSPPVVDTTKGKVLGKYVSLEGFTQPVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVKNT 82
            ::||   ..::||..|:|.|.........:|...|.|:|:||||:|.|||..|:|.|||..|.|.
  Fly    28 STGH---TVILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNC 89

  Rat    83 TT--YPPMCSQDGVVGKLLADMLSTGKENIPL---EFSEDCLYLNIYSPADLTKNSRLPVMVWIH 142
            ||  ..||                  :.|:.|   |.|||||:||:|..| |.....|||:|||:
  Fly    90 TTNRSKPM------------------QRNMLLGIVEGSEDCLHLNVYVKA-LKSEKPLPVIVWIY 135

  Rat   143 GGGLIIGGASP--YSGLALSAHENVVVVTIQYRLGIWGLFSTGDE--HSRGNWAHLDQLAALRWV 203
            |||...|.||.  ||. .....:.||.|.|.|||...|..|..|.  ...||....||:.||||:
  Fly   136 GGGFQKGEASRDIYSP-DYFMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWI 199

  Rat   204 QDNIANFGGNPDSVTIFGESAGGVSVSVLVLSPLAKNLFHRAISESGVVLT-------------- 254
            ..|||:|.|:|:::|:.|||||..||.|::.:...:.|||:||.:||..|:
  Fly   200 SQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPDNNWAFRL 264

  Rat   255 -TNLDKKNTQAVAQMIATLSGCNNTSSAAMVQCLRQKTEAELLELTVKLDNT------SMSTVI- 311
             .||..|..:..|.:::.||..          |.||  .|.:.:..:.||..      :...||
  Fly   265 AQNLGYKGDEKDADVLSFLSKV----------CARQ--IAAIDQDVINLDEVRSFLLFAFGPVIE 317

  Rat   312 ----DGVVLPKTPEEILTEKSFNTVPYIVGFNKQE--FG--------WIIPTMMGNLLSEGRMNE 362
                |..|:||..:::|:|...|.:|.|||.|..|  |.        |.:......|..|.|...
  Fly   318 PYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRKDPWALKNFHNILPREVRETS 382

  Rat   363 KMASS--LLRRFSPNLNISESVIPAIIEKYLRGTDDPAKKKELL--LDMFS--DVFFGIPAVLMS 421
            .:...  |:||.                |.|...::..:..|:.  |::||  .::......:::
  Fly   383 SLEGQDLLVRRL----------------KQLYFNNEMQESMEMFEALNIFSHRQIWHDTHRFILA 431

  Rat   422 RSLRDAGAPTYMYEFQY-RPSFVSDQRPQTVQGD------HGDEI----FSVFGTPFLKEGASEE 475
            |.......|||:|.|.: .|.|  :|..:.|.||      |.||:    :::..:...|  :|.|
  Fly   432 RQSYAPKTPTYLYRFDFDSPHF--NQFRRLVCGDRIRGVAHADELSYLFYNIIASKLDK--SSME 492

  Rat   476 ETNLSKLVMKFWANFARNGNPNGEGLPHWPEYDQKEGYLQIGATTQQAQKLKGEEV 531
            ...:.::| ..|.:||.:||||      .||         :|:...:|.:||...|
  Fly   493 YKTIERMV-GMWTSFASSGNPN------CPE---------LGSAKWEAVQLKENAV 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ces1c	XP_006255234.2	COesterase	24..534	CDD:395084	170/570 (30%)
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	166/558 (30%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	45/105 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720