DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ephb1 and Eph

DIOPT Version :9

Sequence 1:NP_001097998.1 Gene:Ephb1 / 24338 RGDID:2556 Length:984 Species:Rattus norvegicus
Sequence 2:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster


Alignment Length:1075 Identity:461/1075 - (42%)
Similarity:616/1075 - (57%) Gaps:153/1075 - (14%)


- Green bases have known domain annotations that are detailed below.


  Rat     3 LDCLLLFLLA---SAVAAMEETLMDTRTATAELGWTANP------ASGWEEVSGYD--ENLNTIR 56
            |..:||.:::   ....|.:..|:|| |..|.|.||..|      ..||.|.|..|  :.:|. |
  Fly    65 LRTILLIIISIHFKLAHADQVVLLDT-TREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINW-R 127

  Rat    57 TYQVCNVFEPNQNNWLLTTFINRRGAHRIYTEMRFTVRDCSSLPNVPGSCKETFNLYYYETDSVI 121
            :|.||:|...|.||||.:.||:|..|:|:|.|::||:||||..|....||||||:|.:||.|:  
  Fly   128 SYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDA-- 190

  Rat   122 ATKKSAFWSEAPYLKVDTIAADES-FSQ---VDFGGRLMKVNTEVRSFGPLTRNGFYLAFQDYGA 182
            ||::...|....|..:..|||.|. |:|   ||       :||||:|.. :.:.|.|.||:|.||
  Fly   191 ATREPPPWQTDSYRLIARIAAGEGRFNQNSDVD-------INTEVKSIA-VNKKGVYFAFRDQGA 247

  Rat   183 CMSLLSVRVFFKKCPSIVQNFAVFPETMTGAESTSLVIARGTCIPNAEEVDVPIKLYCNGDGEWM 247
            |:|:|:|:|::..||::.:|||.|.||.||.|.|.:....|||:.|||..:.|..| |.|||:|.
  Fly   248 CISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYL-CKGDGKWT 311

  Rat   248 VPIGRCTCKAGYEPE-NSVACKACPAGTFKASQEAEGCSHCPSNSRSPSEASPICTCRTGYYRAD 311
            :..|.|.|||||||. .:..|..||.|||| |.|...|:.||.||.:....||.|.|.:|:||..
  Fly   312 ILTGGCRCKAGYEPNYTNKTCTECPLGTFK-SPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHP 375

  Rat   312 FDPPEVACTSVPSGPRNV-ISIVNETSIILEWHPP-------RETGGR---DDVTYNIICKKCRA 365
            .|...:.|.|.|:.|.|: :..|::||.|:.|..|       .||..:   .|:.|.|       
  Fly   376 NDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI------- 433

  Rat   366 DRRSCSRCDDNVEFVPRQLGLTECRVSISSLWAHTPYTFDIQAINGVSSKSPFPPQH------VS 424
               .|:.|..||.:.|......|.::::::|...|.||..|.|||.||..:.| .:|      |:
  Fly   434 ---KCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEF-KRHSNESSLVA 494

  Rat   425 VN---------------------------ITTNQAAPSTVPIMHQVSATMRSITLSWPQPEQPNG 462
            |:                           .||.....|||..:..::.|.:...|.|.:|.|.:.
  Fly   495 VSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDF 559

  Rat   463 IILDYEIRYYEK-EHNEFNSSMARSQTNTARIDGLRPGMVYVVQVRARTVAGYGKFSGKMCFQTL 526
            .:..||:|::.| |.:..|.|...::...|.|.||.....|..|||.:|..|:|.:|..:..|||
  Fly   560 PLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTL 624

  Rat   527 T------DDDYKSELREQLPLIAGSAAAGVVFVVSLVAISIVCSRKRAYSKEAVYSDKLQHYSTG 585
            .      ||..      |:..|||:...||:|:|..:..::       |...:.:.|.|...||.
  Fly   625 QSVGSVYDDSV------QIRFIAGAIVTGVLFLVIFIIATV-------YFMRSKHQDDLDKKSTN 676

  Rat   586 R----------------GSPGMK---------------IYIDPFTYEDPNEAVREFAKEIDVSFV 619
            .                .:|.:|               .|:||.||||||:|:||||:|||.:::
  Fly   677 HLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYI 741

  Rat   620 KIEEVIGAGEFGEVYKGRLKLPGK--REIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIR 682
            .||.:||.||||:|.:||||:|..  ::|.|||||||.|.|||.|.|||:||||||||||||:|.
  Fly   742 TIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIY 806

  Rat   683 LEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAA 747
            |:||||:|.|||||||:||||:||:|||.|||:|..:||:.||||||:||.|||:||||||||||
  Fly   807 LQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAA 871

  Rat   748 RNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGI 812
            ||:|||:.|:||::||||||.: ::.|| .||:. |||||||||||||||:|||||||||||||:
  Fly   872 RNVLVNAQLICKIADFGLSREI-ENASD-AYTTR-GGKIPVRWTAPEAIAFRKFTSASDVWSYGV 933

  Rat   813 VMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNT 877
            |:|||||:||||||:.||||||.:||:.||||.|||||.||:|||||||||.|..||.||.||:|
  Fly   934 VLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVST 998

  Rat   878 LDKMIRNPASLKTVATITAVPSQPLLD----RSIPDFTAFTTVDDWLSAIKMVQYRDSFLTAGFT 938
            ||.:.|.|.||.|...........:||    ::|     |.:.|.||..|||.:|...|..|...
  Fly   999 LDNLARQPQSLLTTRPSPESDGNHILDGQRGQNI-----FISTDLWLEHIKMSRYCHHFKEANLI 1058

  Rat   939 SLQLVTQMTSEDLLRIGVTLAGHQKKILSSIHSMR 973
            :.|.::::|::.|..:|:||.|||||||   |..|
  Fly  1059 NAQQISRLTAQQLSDMGITLVGHQKKIL---HQAR 1090

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ephb1NP_001097998.1 EphR_LBD_B1 20..195 CDD:198444 78/186 (42%)
fn3 326..412 CDD:394996 27/96 (28%)
fn3 435..518 CDD:394996 26/83 (31%)
EphA2_TM 542..616 CDD:405290 30/104 (29%)
PTKc_EphR_B 614..882 CDD:173638 190/269 (71%)
SAM_EPH-B1 908..975 CDD:188950 25/66 (38%)
PDZ-binding. /evidence=ECO:0000255 982..984
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 78/186 (42%)
FN3 387..476 CDD:238020 27/98 (28%)
FN3 536..623 CDD:238020 24/86 (28%)
EphA2_TM 644..736 CDD:291255 25/98 (26%)
PTKc_EphR 736..1002 CDD:270629 190/268 (71%)
Pkinase_Tyr 741..999 CDD:285015 185/260 (71%)
SAM_1 1033..1092 CDD:278937 25/61 (41%)
SAM 1039..1092 CDD:197735 23/55 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 399 1.000 Domainoid score I718
eggNOG 1 0.900 - - E2759_KOG0196
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20936
Inparanoid 1 1.050 763 1.000 Inparanoid score I521
OMA 1 1.010 - - QHG45908
OrthoDB 1 1.010 - - D397694at33208
OrthoFinder 1 1.000 - - FOG0000086
OrthoInspector 1 1.000 - - otm46382
orthoMCL 1 0.900 - - OOG6_100189
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X82
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1413.740

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