DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Erbb2 and Egfr

DIOPT Version :9

Sequence 1:	NP_058699.2	Gene:	Erbb2 / 24337	RGDID:	2561	Length:	1259	Species:	Rattus norvegicus
Sequence 2:	NP_476759.1	Gene:	Egfr / 37455	FlyBaseID:	FBgn0003731	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	1443	Identity:	475/1443 - (32%)
Similarity:	666/1443 - (46%)	Gaps:	360/1443 - (24%)

- Green bases have known domain annotations that are detailed below.

  Rat    27 QVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYVP-ANASLSFLQDIQEVQGYMLIA 90
            ::|.||..:|.:|::.|.|...||..|..|..|.||||||::| .|..||||.:|:||.||:||:
  Fly   100 KICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLDLSFLDNIREVTGYILIS 164

  Rat    91 HNQVKRVPLQRLRIVRGTQLF-----EDKYALAVLDNRDPQDNVAASTPGRTPEGLRELQLRSLT 150
            |..||:|...:|:|:||..||     |:||||.|                 |...:..|::..|.
  Fly   165 HVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFV-----------------TYSKMYTLEIPDLR 212

  Rat   151 EILKGGVLIRGNPQLCYQDMVLWKDVFRKNNQLAPVDID-TNRSRACPPCAPACKDNHCWGESPE 214
            ::|.|.|....|..||:...:.|.::. .|...|..:.| |...|.||.|..:| .:.||||.|:
  Fly   213 DVLNGQVGFHNNYNLCHMRTIQWSEIV-SNGTDAYYNYDFTAPERECPKCHESC-THGCWGEGPK 275

  Rat   215 DCQILTGTICTSGCA--RCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVT 277
            :||..:...|:..||  ||.|..|.:|||..||.|||||...||:||.:|...|:|:..||.:..
  Fly   276 NCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRK 340

  Rat   278 YNTDTFESMHNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTAEDGTQRCEKCSKPC 342
            ||..|:....||||:|.:||:||..|| .:|..:.|:|...||.:..:...|     |..|:.||
  Fly   341 YNPTTYVLETNPEGKYAYGATCVKECP-GHLLRDNGACVRSCPQDKMDKGGE-----CVPCNGPC 399

  Rat   343 ARVCYGLGMEHLRGARAITSDNVQEFDGCKKIFGSLAFLPESFDG------DPSSG--IAPLRPE 399
            .:.|.|:.:.|        :.|:..|..|..|.|::..|.::|.|      :.:.|  ..||.||
  Fly   400 PKTCPGVTVLH--------AGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPE 456

  Rat   400 QLQVFETLEEITGYLYISAWPDSLRDLSVFQNLRIIRGRILHDGAY-SLTLQGLGIHSLGLRSLR 463
            :|:||.|::||||||.|.......|:||.|:||..|.||.|.:..: :|.:....::||.:|:|:
  Fly   457 RLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLK 521

  Rat   464 ELGSGLALIHRNAHLCFVHTVPWDQLFRNPHQALLHSGNRPEEDCGLEGLVCNSLCAHGHCWGPG 528
            ::.||..:|..|..||:|..:.|..:.:.|.|.:..:.|...:.|...|.:|:..|....|||.|
  Fly   522 QISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAG 586

  Rat   529 PTQCVNCSHFLRGQECVEECRVWKGLPREYVSDKR-CLPCHPECQPQNSSETCFGSEADQCAACA 592
            ..||:.|.:|.....|:.:|..   :...|..|.| |..|||||:      ||.|:.||.|..|.
  Fly   587 TDQCLTCKNFNFNGTCIADCGY---ISNAYKFDNRTCKICHPECR------TCNGAGADHCQECV 642

  Rat   593 HYKDSSSCVARCP--------------------SGVK---------------------------- 609
            |.:|...||:.||                    :|.|
  Fly   643 HVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLK 707

  Rat   610 ----PDLSYMPIWKY--PDEEG---------ICQPC-PI---------------NCTH------- 636
                || .|  .|:|  |.|:|         :|:.| |:               .|||
  Fly   708 DDKCPD-GY--FWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQC 769

  Rat   637 ------------------------------------SC-----VDLDERG-------------CP 647
                                                ||     .|.:|.|             ||
  Fly   770 ETECPADHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCP 834

  Rat   648 AEQR--------------ASP-------------VTFIIATVVGVLLFLILVVVVGILIKRRRQK 685
            .|.|              |||             :.|||...|.|....||.||.  .|.|::||
  Fly   835 LEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVT--YICRQKQK 897

  Rat   686 IRKYT--MRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGE 748
            .:|.|  |...|...|..|||.||....|..::||:|:.||||..|||.||||.||||:|:|:||
  Fly   898 AKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGE 962

  Rat   749 NVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDH 813
            |||||||||.|.::|..::::|.|.|||:||.|....:.:||.:|::|.:.|:|||||.|||||:
  Fly   963 NVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDY 1027

  Rat   814 VREHRGRLGSQDLLNWCVQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDE 878
            ||.:|.::||:.||||..||||||||||:.||||||||||||||::|:.|||||||||:||..|.
  Fly  1028 VRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDS 1092

  Rat   879 TEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGE 943
            .||.|.|||:||||:|||.|..|.||.:||||::|||:|||:|||.:|::.|||::||||:|.|.
  Fly  1093 NEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGL 1157

  Rat   944 RLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPSSPMDSTF 1008
            :|.||.||::|:|..::.||.:|:..||.|::|.:.|:..||||.|::.|         |.|...
  Fly  1158 KLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAI---------PGDKFT 1213

  Rat  1009 YRSLLEDDDMGDLV-------DAEEYLVPQQGFFSPDPTPGTGSTAHRRHRSSSTRSGGGELTLG 1066
            ........|..||:       |..|.:.....:..|...||..      ||:..|
  Fly  1214 RLPAYTSQDEKDLIRKLAPTTDGSEAIAEPDDYLQPKAAPGPS------HRTDCT---------- 1262

  Rat  1067 LEPSEEGPP-----RSPLAPSEGAGSDVFDG---DLAMGVTKGLQSLSPHDLSPLQRYSEDPTLP 1123
                :|.|.     :.|...:...|.|..|.   ::.:|..:                     |.
  Fly  1263 ----DEIPKLNRYCKDPSNKNSSTGDDETDSSAREVGVGNLR---------------------LD 1302

  Rat  1124 LPPETDGYVAPLACSPQPEYVNQSEVQPQPPLTPEGPLPPVRPAGATLERPKTLSPGKNGVV--- 1185
            ||.:.|.|:.| .|.|.|.  |.:.:.                           :|.:|.:.
  Fly  1303 LPVDEDDYLMP-TCQPGPN--NNNNIN---------------------------NPNQNNMAAVG 1337

  Rat  1186 -----KDVFAFGGAVENPEYL------------VPRE----------GTASPPHPSPAFSPAFDN 1223
                 .|:.....:|:|||||            :|.:          ||.....|.|...|...:
  Fly  1338 VAAGYMDLIGVPVSVDNPEYLLNAQTLGVGESPIPTQTIGIPVMGVPGTMEVKVPMPGSEPTSSD 1402

  Rat  1224 LYYWDQNSSEQGP 1236
            ..|::....|..|
  Fly  1403 HEYYNDTQRELQP 1415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Erbb2	NP_058699.2	Recep_L_domain	55..177	CDD:279382	47/127 (37%)
		Furin-like	193..342	CDD:279142	60/150 (40%)
		FU	239..284	CDD:238021	22/44 (50%)
		Recep_L_domain	370..490	CDD:279382	45/128 (35%)
		GF_recep_IV	514..647	CDD:291509	55/273 (20%)
		FU	515..565	CDD:238021	15/50 (30%)
		FU	561..607	CDD:214589	21/66 (32%)
		TM_ErbB2	645..688	CDD:213055	21/82 (26%)
		PTKc_HER2	716..994	CDD:270684	162/277 (58%)
		Pkinase_Tyr	724..980	CDD:285015	152/255 (60%)
Egfr	NP_476759.1	Recep_L_domain	419..547	CDD:279382	45/127 (35%)
		GF_recep_IV	572..684	CDD:291509	36/120 (30%)
		FU	573..>606	CDD:238021	11/32 (34%)
		FU	617..659	CDD:214589	20/47 (43%)
		FU	662..716	CDD:214589	5/56 (9%)
		FU	739..786	CDD:238021	5/46 (11%)
		FU	784..834	CDD:214589	5/49 (10%)
		PTKc_EGFR_like	930..1208	CDD:270648	163/286 (57%)
		STYKc	938..1194	CDD:214568	152/255 (60%)
		Recep_L_domain	128..239	CDD:279382	47/127 (37%)
		Furin-like	253..401	CDD:279142	62/154 (40%)
		FU	255..292	CDD:214589	15/37 (41%)
		FU	302..345	CDD:238021	21/42 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	339	1.000	Domainoid score	I1062
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45861
OrthoDB	1	1.010	-	-		D51516at33208
OrthoFinder	1	1.000	-	-		FOG0000755
OrthoInspector	1	1.000	-	-		otm44735
orthoMCL	1	0.900	-	-		OOG6_101159
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X448
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.790