DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Egfr and Egfr

DIOPT Version :9

Sequence 1:NP_113695.2 Gene:Egfr / 24329 RGDID:2543 Length:1209 Species:Rattus norvegicus
Sequence 2:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster


Alignment Length:1340 Identity:486/1340 - (36%)
Similarity:682/1340 - (50%) Gaps:285/1340 - (21%)


- Green bases have known domain annotations that are detailed below.


  Rat    24 ALEEK--------KVCQGTSNRLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYV-QRNYDLSFL 79
            :||:|        |:|.||.:||:.....|.|:.:|:..:.||..|.||||:|:: ..|.|||||
  Fly    87 SLEDKNKNEFVKGKICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLDLSFL 151

  Rat    80 KTIQEVAGYVLIALNTVERIPLENLQIIRGNALY-----ENTYALAVLSNYGTNKTGLRELPMRN 139
            ..|:||.||:||:...|:::....||||||..|:     |..|||.|  .|  :|....|:|  :
  Fly   152 DNIREVTGYILISHVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFV--TY--SKMYTLEIP--D 210

  Rat   140 LQEILIGAVRFSNNPILCNMETIQWRDIVQDVFLSNMSMDVQRHLTGCPKCDPSCPNGSCWGRGE 204
            |:::|.|.|.|.||..||:|.||||.:||.:...:..:.|.......||||..||.:| |||.|.
  Fly   211 LRDVLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERECPKCHESCTHG-CWGEGP 274

  Rat   205 ENCQKLTKIICAQQCS-RRCRGRSPSDCCHNQCAAGCTGPRESDCLVCHRFRDEATCKDTCPPLM 268
            :||||.:|:.|:.||: .||.|..|.:|||..||.|||||.:.||:.|..|.||..||:.|||:.
  Fly   275 KNCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMR 339

  Rat   269 LYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYEVEEDGVSKCKKCDGPC 333
            .||||||.::.||||||::||||||:|| .:::.|:|:|||:|..|  ::::.|  :|..|:|||
  Fly   340 KYNPTTYVLETNPEGKYAYGATCVKECP-GHLLRDNGACVRSCPQD--KMDKGG--ECVPCNGPC 399

  Rat   334 RKVCNGIGIGEFKDTLSINATNIKHFKYCTAISGDLHILPVAFKG-----DSFTRTP---PLDPR 390
            .|.|.|:.:        ::|.||..|:.||.|.|::.||...|.|     .::|..|   ||||.
  Fly   400 PKTCPGVTV--------LHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPE 456

  Rat   391 ELEILKTVKEITGFLLIQAWPENWTDLHAFENLEIIRGRTKQHGQF-SLAVVGLNITSLGLRSLK 454
            .||:..|||||||:|.|:.....:.:|..|.|||.|.||......| :||:|..::.||.:|:||
  Fly   457 RLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLK 521

  Rat   455 EISDGDVIISGNRNLCYANTINWKKLFGTPNQKTKIMNNRAEKDCKATNHVCNPLCSSEGCWGPE 519
            :||.|.|:|..||:|||.:.|.|..:...|.||..:..|.....|:....:|:..|:.:||||..
  Fly   522 QISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAG 586

  Rat   520 PTDCVSCQNVSRGRECVDKCNILEGEPREFVENSECIQCHPECLPQTMNITCTGRGPDNCIKCAH 584
            ...|::|:|.:....|:..|..:....:  .:|..|..|||||.      ||.|.|.|:|.:|.|
  Fly   587 TDQCLTCKNFNFNGTCIADCGYISNAYK--FDNRTCKICHPECR------TCNGAGADHCQECVH 643

  Rat   585 YVDGPHCVKTCP-----------------SGIMGENNTL-------------------------- 606
            ..||.|||..||                 .|..|..:|:                          
  Fly   644 VRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLKD 708

  Rat   607 -------VWKFADANN-----------VCHLCH----------------ANCTY----------- 626
                   .|::.....           ||..||                :.||:           
  Fly   709 DKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETEC 773

  Rat   627 ---------------------GCAGPGLKGCQQ-------------------------------- 638
                                 ||.|||...|:.                                
  Fly   774 PADHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMR 838

  Rat   639 -----------------PEGPKIPS--------IATGIVGGLLFIVVVALGIGLFMRRRHIVRKR 678
                             |...||.:        |.||.|  |:..:.:...:....|::...:|.
  Fly   839 HVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAV--LVPTICILCVVTYICRQKQKAKKE 901

  Rat   679 TLR--RLLQERELVEPLTPSGEAPNQAHLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKI 741
            |::  ..|...|..|||.||....|...|||:|:.|.:|..|||.||||.||||:|:||||.|||
  Fly   902 TVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKI 966

  Rat   742 PVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPYGCLLDYVREH 806
            |||||||.::|..::::|.|.|||:||||::.::.:||.:|::|.:.|||||||.||||||||.:
  Fly   967 PVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNN 1031

  Rat   807 KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYH 871
            :|.|||:.||||..||||||:|||::||||||||||||||:||..||||||||||||.::..||.
  Fly  1032 RDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYK 1096

  Rat   872 AEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQ 936
            |.|||:||||:|||.|.:|::|.:||||::|||:|||:|||.:|::.|||.:|..::|.|.:|.|
  Fly  1097 AAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQ 1161

  Rat   937 PPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYLVIQGDERMHLPSPT---DSNF 998
            |.||::|:|..::.||.:||..||.|::|...|::.||||.|||.|.||:...||:.|   :.:.
  Fly  1162 PEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDL 1226

  Rat   999 YRALMEEED-MEDVVDADEYLIPQQGFFNSPSTSRTPLLSSLSANSNSSAVACINRNGSCRVKED 1062
            .|.|....| .|.:.:.|:||.|:                  :|...|....|.:        |.
  Fly  1227 IRKLAPTTDGSEAIAEPDDYLQPK------------------AAPGPSHRTDCTD--------EI 1265

  Rat  1063 AFLQRYSSDPTSVLTEDNIDDTFLPVPEYINQSVPKRPAGSVQ--NPV----YHNQPLHPAPGRD 1121
            ..|.||..||::..:....|:|        :.|..:...|:::  .||    |......|.|..:
  Fly  1266 PKLNRYCKDPSNKNSSTGDDET--------DSSAREVGVGNLRLDLPVDEDDYLMPTCQPGPNNN 1322

  Rat  1122 LHYQNPHSN-------------------AVSNPEYLNTAQ 1142
            .:..||:.|                   :|.|||||..||
  Fly  1323 NNINNPNQNNMAAVGVAAGYMDLIGVPVSVDNPEYLLNAQ 1362

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgfrNP_113695.2 None
EgfrNP_476759.1 Recep_L_domain 419..547 CDD:279382 56/136 (41%)
GF_recep_IV 572..684 CDD:291509 38/172 (22%)
FU 573..>606 CDD:238021 10/32 (31%)
FU 617..659 CDD:214589 19/41 (46%)
FU 662..716 CDD:214589 21/202 (10%)
FU 739..786 CDD:238021 19/48 (40%)
FU 784..834 CDD:214589 32/49 (65%)
PTKc_EGFR_like 930..1208 CDD:270648 102/305 (33%)
STYKc 938..1194 CDD:214568 90/284 (32%)
Recep_L_domain 128..239 CDD:279382 49/116 (42%)
Furin-like 253..401 CDD:279142 75/148 (51%)
FU 255..292 CDD:214589 18/37 (49%)
FU 302..345 CDD:238021 23/42 (55%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 339 1.000 Domainoid score I1062
eggNOG 1 0.900 - - E1_KOG1025
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45861
OrthoDB 1 1.010 - - D51516at33208
OrthoFinder 1 1.000 - - FOG0000755
OrthoInspector 1 1.000 - - otm44735
orthoMCL 1 0.900 - - OOG6_101159
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X448
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1211.790

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