DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and Ance

DIOPT Version :9

Sequence 1:	NP_036676.1	Gene:	Ace / 24310	RGDID:	2493	Length:	1313	Species:	Rattus norvegicus
Sequence 2:	NP_001285915.1	Gene:	Ance / 34805	FlyBaseID:	FBgn0012037	Length:	615	Species:	Drosophila melanogaster

Alignment Length:	599	Identity:	263/599 - (43%)
Similarity:	373/599 - (62%)	Gaps:	29/599 - (4%)

- Green bases have known domain annotations that are detailed below.

  Rat   648 LETDEAKANRFVEEYDRTAKVLWNEYAEANWHYNTNITIEGSKILLQKN----------KEVSNH 702
            |..:|.:|..::|..::......|...||.|.|.:|||.|..|   :||          |||::.
  Fly    18 LVKEEIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEK---KKNEISAELAKFMKEVASD 79

  Rat   703 TLKYGTWAKTFDVSNFQNSTIKRIIKKVQNVDRAVLPPNELEEYNQILLDMETTYSVANVC-YTN 766
            |.|: .|      .::|:..:||..|.:..:..|.||.::..|....|..||:.::...|| |.:
  Fly    80 TTKF-QW------RSYQSEDLKRQFKALTKLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKD 137

  Rat   767 GT-C-LSLEPDLTNIMATSRKYEELLWVWKSWRDKVGRAILPFFPKYVDFSNKIAKLNGYSDAGD 829
            .| | |:|:|::..:::.||.:|||.:.|:.:.||.|.|:...|.:||:.:.|.||||.::...:
  Fly   138 STKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAVRSQFERYVELNTKAAKLNNFTSGAE 202

  Rat   830 SWRSSYESDDLEQDLEKLYQELQPLYLNLHAYVRRSLHRHYGSEYINLDGPIPAHLLGNMWAQTW 894
            :|...||.|..||.||.::.:::|||..:|.|||..|.:|||...::..||||.|||||||||.|
  Fly   203 AWLDEYEDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMHLLGNMWAQQW 267

  Rat   895 SNIYDLVAPFPSAPSIDATEAMIKQGWTPRRIFKEADNFFTSLGLLPVPPEFWNKSMLEKPTDGR 959
            |.|.|:|:|||..|.:|.:..|.|||:||.::|:..|:||||:.|..:|.:||:||::|||||||
  Fly   268 SEIADIVSPFPEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDGR 332

  Rat   960 EVVCHASAWDFYNGKDFRIKQCTSVNMEELVIAHHEMGHIQYFMQYKDLPVTFREGANPGFHEAI 1024
            ::||||||||||...|.||||||.|..::|...|||:||||||:||:..|..:|.|||||||||:
  Fly   333 DLVCHASAWDFYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAV 397

  Rat  1025 GDVLALSVSTPKHLHSLNLLSSEGSGYEHDINFLMKMALDKIAFIPFSYLIDQWRWRVFDGSITK 1089
            ||||:|||||||||..:.||.......|..||.|...|||||.|:||::.:|::||.:|.|.:.|
  Fly   398 GDVLSLSVSTPKHLEKIGLLKDYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDK 462

  Rat  1090 ENYNQEWWSLRLKYQGLCPPVPRSQGDFDPGSKFHVPANVPYIRYFISFIIQFQFHEALCRAAGH 1154
            .|:|..:|.||.:|.|:.|||.||:.|||..:|:|:.|:|.|:||.:||||||||:::.|..||.
  Fly   463 ANWNCAFWKLRDEYSGIEPPVVRSEKDFDAPAKYHISADVEYLRYLVSFIIQFQFYKSACIKAGQ 527

  Rat  1155 TG------PLYKCDIYQSKEAGKLLADAMKLGYSKQWPEAMKIITGQPNMSASAIMNYFKPLTEW 1213
            ..      ||..||||.|..||....:.:.:|.||.||:|::...|:..||..||..||:||..|
  Fly   528 YDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALEAFNGERIMSGKAIAEYFEPLRVW 592

  Rat  1214 LVTENRRHGETLGW 1227
            |..||.::...:||
  Fly   593 LEAENIKNNVHIGW 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_036676.1	Peptidase M2 1	36..636
		Peptidase_M2	46..629	CDD:279709
		Peptidase M2 2	637..1238		263/599 (44%)
		Peptidase_M2	650..1227	CDD:279709	260/595 (44%)
Ance	NP_001285915.1	Peptidase_M2	19..606	CDD:279709	260/596 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	532	1.000	Domainoid score	I271
eggNOG	1	0.900	-	-		E1_KOG3690
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	478	1.000	Inparanoid score	I1420
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266227at33208
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	1	1.000	-	-		mtm8935
orthoMCL	1	0.900	-	-		OOG6_101615
Panther	1	1.100	-	-	O	PTHR10514
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1436
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.830