DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4b1 and Cyp6a8

DIOPT Version :9

Sequence 1:	NP_058695.2	Gene:	Cyp4b1 / 24307	RGDID:	2480	Length:	511	Species:	Rattus norvegicus
Sequence 2:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	128/550 - (23%)
Similarity:	227/550 - (41%)	Gaps:	116/550 - (21%)

- Green bases have known domain annotations that are detailed below.

  Rat    17 ASVVILMVIVLKLFSLL---LRRQKLARAMDSFPGPPTHWLFGHALEIQKLGSLDKVV-SWAQQF 77
            |...||..:.:.|.::|   :.|:.........|....|.:.|:..|:||..::.::. ....:|
  Fly     2 ALTYILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKF 66

  Rat    78 PHAHPLWFGQFVGFLNIYEP----------------DYA----KAVY--SRGDPKAADVYDFFLQ 120
            ..:.    ..||||.....|                |::    |.::  .:.||.:|.:::
  Fly    67 RESK----APFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPISAHLFN---- 123

  Rat   121 WIGKGLLVLDGPKWFQHRKLLTPGFHYDVLK---PYVAIFAESTRMMLDKWEKKASENKSFDIFC 182
                    |||.:|...|..|:..|....:|   |.|...|.....::   .:|..:|...:|..
  Fly   124 --------LDGAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVM---HEKVPKNSVLEIRD 177

  Rat   183 DVGHMALDTLMKCTFGKGDSGLGHRDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRR-- 245
            .|....:|.:..|.||...:.|  ||..                      .:|:|:    |:|
  Fly   178 LVARFTVDVIGTCAFGIQCNSL--RDEK----------------------AEFLYF----GKRSL 214

  Rat   246 -----------FLR-----ACKIAHDHTDEVIRQRKAALQDEKERKKIQQRRHL---DFLDILLG 291
                       |:|     |.|:....|...|::..:.:  ..|...::::.|:   ||:|:|:.
  Fly   215 VDKRHGTLLNGFMRSYPKLARKLGMVRTAPHIQEFYSRI--VTETVAVREKEHIKRNDFMDMLIE 277

  Rat   292 VRDESGIKLSDA---------ELRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQLCREEVRG 347
            ::::..:.|.:.         |:.|:...|...|.:|::|.:.:.||.:|..|:.|...|.||..
  Fly   278 LKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEE 342

  Rat   348 ILGDQD-SFQWDDLAKMTYLTMCMKECFRLYPPVPQVYRQLNKPVTFVDGRS---LPAGSLISLH 408
            ::...| :|.::....:.||...:.|..|||..||.:.|...|... |.|..   :.||..:.:.
  Fly   343 VIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNLDRMAAKRYV-VPGHPNFVIEAGQSVIIP 406

  Rat   409 IYALHRNSTVWPDPEVFDPLRFSPENAAGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLR 473
            ..|:|.:.:::|:|..|.|.|||||.:|||...|::||..|||||||.:|...:.::..||.:..
  Fly   407 SSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRN 471

  Rat   474 FEFSL---DPSKMPIKVPQLILRSKNGIHL 500
            |:||.   .|:.:.......:|..|:||:|
  Fly   472 FKFSTCSKTPNPLVYDPKSFVLGVKDGIYL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4b1	NP_058695.2	p450	47..500	CDD:278495	121/515 (23%)
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	120/512 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900