DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4b1 and Cyp9b2

DIOPT Version :9

Sequence 1:	NP_058695.2	Gene:	Cyp4b1 / 24307	RGDID:	2480	Length:	511	Species:	Rattus norvegicus
Sequence 2:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	423	Identity:	104/423 - (24%)
Similarity:	174/423 - (41%)	Gaps:	45/423 - (10%)

- Green bases have known domain annotations that are detailed below.

  Rat    87 QFVGFLNIYEPDYAKAVYSRGDP---KAADVYDF--------FL----QWIGKGLLVLDGPKWFQ 136
            :.|||.|:..|     :.:..||   |...|.||        |:    :.....|.|:...:|..
  Fly    70 KLVGFFNMRTP-----MITLNDPELIKKVCVKDFDHFPNHQPFITSNDRLFNDMLSVMRDQRWKH 129

  Rat   137 HRKLLTPGFHYDVLKPYVAIFAES---TRMMLDKWEKKASENKSFDIFCDV--GHMALDTLMKCT 196
            .|..|||.|....::....:..||   ....||...|.....|.|::...|  ..::.|.:....
  Fly   130 MRNTLTPVFTAAKMRNMFTLMNESFAECLQHLDSSSKTLPGRKGFEVDMKVMCNKLSNDIIATTA 194

  Rat   197 FGKGDSGLGHRDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACKIAHDHTDEVI 261
            ||...:...:..|.:|  ....:|:..:.:..|::   .:..|.|.....|:.........|...
  Fly   195 FGLKVNSYDNPKNEFY--EIGQSLVFSRGLQFFKF---MLSTLVPKLFSLLKLTIFDSAKVDYFA 254

  Rat   262 RQRKAALQDEKERKKIQQRRHLDFLDILLGVRDESGIKLSDAELRAEVDTFMFEGHDTTTSGISW 326
            |....|:| .:|:..|.:.   |.:.:|:..::||..|.:|.|:.|:...|.|...:..::.|..
  Fly   255 RLVVEAMQ-YREKHNITRP---DMIQLLMEAKNESEDKWTDDEIVAQCFIFFFAAFENNSNLICT 315

  Rat   327 FLYCMALYPEHQQLCREEV----RGILGDQDSFQWDDLAKMTYLTMCMKECFRLYPPVPQVYRQL 387
            ..|.:...|:.|:...||:    :.:.|  ....:|.:.||||:.|.:.|..|.:.......|..
  Fly   316 TTYELLYNPDVQERLYEEIVETKKALNG--APLTYDAVQKMTYMDMVISESLRKWTLAAATDRLC 378

  Rat   388 NKPVTFV--DGRSL---PAGSLISLHIYALHRNSTVWPDPEVFDPLRFSPENAAGRHPFAFMPFS 447
            :|..|..  ||..|   ..|..|::.|..||.:...:|:|..|||.|||.|......|:.::||.
  Fly   379 SKDYTLTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPRKFDPDRFSEERKGDMVPYTYLPFG 443

  Rat   448 AGPRNCIGQQFAMNEMKVVTALCLLRFEFSLDP 480
            .|||||||.::|:.::|.:....||.::....|
  Fly   444 VGPRNCIGNRYALMQVKGMLFNLLLHYKIEASP 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4b1	NP_058695.2	p450	47..500	CDD:278495	104/423 (25%)
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	104/423 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900