DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4b1 and Cyp4ac3

DIOPT Version :9

Sequence 1:	NP_058695.2	Gene:	Cyp4b1 / 24307	RGDID:	2480	Length:	511	Species:	Rattus norvegicus
Sequence 2:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	149/522 - (28%)
Similarity:	255/522 - (48%)	Gaps:	50/522 - (9%)

- Green bases have known domain annotations that are detailed below.

  Rat     1 MVLNFLSPSLSRLGLWASVVILMVIVLKLFSLLLRRQKLARAMDSFP------GPPTHWLFGHAL 59
            |.:..|..||....||     |::..|.....:|...|..|..|..|      ..|....||:.|
  Fly     1 MWIALLGSSLLIGALW-----LLLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKTRFGNNL 60

  Rat    60 EIQKLGSLDKVVSWAQQFP----HAHPLWFGQFVGFLNIYEPDYAKAVYSRGDPKAADV-YDFFL 119
            ::..|...: :.|:.::..    ..:.:|...|....||...:.|:.::........:: |:...
  Fly    61 DLLNLTPAN-IFSYIRESTAKANGQNYIWNFLFAPEYNIVRAEDAEEIFQSTKITTKNMSYELIR 124

  Rat   120 QWIGKGLLVLDGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRMMLDKWEKKASENKSFDIFCD- 183
            .::|.|||:....||...||.|||.||:::|:.:::||.|.::    |:.|...:|..|::..:
  Fly   125 PFLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEESK----KFIKILDKNVGFELELNQ 185

  Rat   184 -VGHMALDTLMKCTFG--KGDSGLGHRDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRR 245
             :....|:.:.:...|  ..|...|   |.|..|:.|..::..||:.:.....::.::|....::
  Fly   186 IIPQFTLNNICETALGVKLDDMSEG---NEYRKAIHDFEIVFNQRMCNPLMFFNWYFFLFGDYKK 247

  Rat   246 FLRACKIAHDHTDEVIRQRKAALQDEKERKKIQQ---RRHLDFLDILLGVRDESGIKLSDAELRA 307
            :.|..:..|..:..:| |||.....:|:..::.:   ::....||.||....|.  |:....:..
  Fly   248 YSRILRTIHGFSSGII-QRKRQQFKQKQLGQVDEFGKKQRYAMLDTLLAAEAEG--KIDHQGICD 309

  Rat   308 EVDTFMFEGHDTTTSGISWFLYCMALYPEHQQLCREEVRGILGDQDS---FQWDDLAKMTYLTMC 369
            ||:||||.|:|||::.:.:.|..:||:.:.|:.|.||::.:..|.|.   ||:::|   .:|...
  Fly   310 EVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDIDEVSMFQFNEL---IHLECV 371

  Rat   370 MKECFRLYPPVPQVYRQLNKPVTFVDGRSLPAGSLISLHIYALHRNSTVWPDPEVFDPLRFSPEN 434
            :||..||:|..|.:.|...:. :.::|..||..:.||:|||.:.|::..:|.|..|.|.||.|||
  Fly   372 IKESLRLFPSAPIIGRTCIEE-SVMNGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERFLPEN 435

  Rat   435 AAGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSLDPSKMPIKVPQL-ILRSKNGI 498
            :..||||||:||||||||||||:|.:.|:||:.|..:..|:.        :...|| .|..:|||
  Fly   436 SVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKL--------LPATQLEDLTFENGI 492

  Rat   499 HL 500
            .|
  Fly   493 VL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4b1	NP_058695.2	p450	47..500	CDD:278495	136/474 (29%)
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	136/467 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348755
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850